乙胺嘧啶

乙胺嘧啶对二硝基氟苯所致小鼠接触超敏性和耐受性的影响

The effect of pyrimethamine on contact sensitivity and tolerance to DNFB in mice

氯喹与乙胺嘧啶对孕鼠和胚胎的毒性

The embryotoxicity of chloroquine and pyrimethamine in rats

本实验应用Feulgen组化染色研究乙胺嘧啶作用后约氏疟原虫卵囊内核酸含量的变化，并在显微分光光度计下进行DNA含量测定。

Feulgen stain and microspectrophotometer were used for the study of the effect of pyrimethamine on the DNA amount of oocysts of Plasmodium yoelii yoelii .

抗疟药咯萘啶与磺胺多辛及乙胺嘧啶配伍治疗恶性疟结果的分析

Analysis on results of antimalarial pyronaridine combined with sulfadoxine and pyrimethamine to falciparum malaria

此外，孕鼠服氯喹与乙胺嘧啶后，尚有阴道与眼眶出血等中毒症状。

Orbital and vaginal hemorrhage was also noted in rats administered with chloroquine and pyrimethamine .

恶性疟原虫对咯萘啶/磺胺多辛/乙胺嘧啶敏感性体外测定方法的研究

Studies on the sensitivity of Plasmodium falciparum to pyronaridine / sulfadoxine / pyrimethamine in vitro

采用磺胺嘧啶和乙胺嘧啶治疗4个疗程，效果满意。

The result of therapy of toxoplasmatic peritonitis administering Sulfadiazine and Pyrimethamine for 4-therapic courses was effective .

甲氧苄氨嘧啶/磺胺甲基异唑与乙胺嘧啶和磺胺嘧啶治疗弓形体性脉络膜视网膜炎的前瞻性随机化试验

Prospective randomized trial of trimethoprim / sulfamethoxazole versus pyrimethamine and sulfadiazine in the treatment of ocular toxoplasmosis

在大多数疟疾流行国家，对氯喹和磺胺多辛+乙胺嘧啶等较早一代抗疟药物的耐药性十分普遍。

Resistance to earlier generation antimalarial medicines such as chloroquine and sulfadoxine-pyrimethamine is widespread in most malaria-endemic countries .

一个让情况变得复杂的因素是，随着人们对于周效磺胺-乙胺嘧啶的耐药性增加，这种药物的效果在非洲东部正在减弱。

A complicating factor is that SP is becoming less effective in East Africa as people 's resistance to the drug grows .

世卫组织建议对生活在高传播地区的孕妇使用磺胺多辛&乙胺嘧啶在妊娠中期和晚期进行间歇性预防治疗。

WHO recommends intermittent preventive treatment with sulfadoxine-pyrimethamine for pregnant women living in high transmission areas , during the second and third trimesters .

咯萘啶与磺胺多辛-乙胺嘧啶单剂及两天疗法加伯氨喹治疗恶性疟的效果

Comparative studies on the treatment of drug resistant falciparum malaria with single dose or two day regimens of pyronaridine / sulfadoxine pyrimethamine plus primaquine

[结论]恶性疟原虫对咯萘啶/磺胺多辛/乙胺嘧啶的敏感性可用体外微量法进行测定。

[ Conclusion ] The in vitro method can be used to assess the sensitivity of P. falciparum to pyronaridine / sulfadoxine / pyrimethamine .

同样，对非洲高传播地区的儿童，建议除在常规疫苗接种外，进行3剂磺胺多辛&乙胺嘧啶间歇性预防治疗。

Similarly , for infants living in high-transmission areas of Africa , 3 doses of intermittent preventive treatment with SP is recommended delivered alongside routine vaccinations .

泰柬边界地区一开始出现的是对氯喹的耐药性，然后对周效磺胺-乙胺嘧啶以及甲氟喹产生耐药性。这些药是几年前使用的抗疟药。

Resistance along the Thai-Cambodia border started with chloroquine , followed by resistance to sulfadoxine-pyrimethamine and mefloquine , drugs used in malaria control several years ago .

螺旋霉素低剂量组传第2代，20只小鼠中2只发病，乙胺嘧啶低剂量组传第3代，20只小鼠有1只发病。

Mice of the second generation in low dose spiramycin group and 1 mouse of the third generation in low dose pyrimethamine group were also found infected .

答：在世界大多数地区，恶性疟原虫已对诸如氯喹、周效磺胺-乙胺嘧啶和单独使用的其它抗疟疾药物等传统治疗产生耐药性。

A : In most parts of the world , falciparum malaria has become resistant to conventional treatment , such as chloroquine , sulfadoxine-pyrimethamine , and other antimalarial medicines used on their own .

对7种常用抗疟药敏感性测试的结果表明，该系除对乙胺嘧啶、周效磺胺和伯喹敏感外，对另外4种药物均显示出程度不等的交叉抗药性。

The susceptibility of this chloroquine-resistant line to 7 antimalarials revealed more sensitive to pyrimethamine , sulfadoxine and primaquine , but exhibited some degree of cross resistance to the other 4 drugs , i. e.

4个化合物（1,8,20,25，表2,3）进行了猴疟（P.cynomolgi）试验，效果不及伯喹和乙胺嘧啶。

In tests against P. cynomolgi in rhesus monkeys , four compounds ( 1 , 8 , 20 , 25 ) were found to be less effective than primaquine and pyrimethamine in the same dosage level .

目前弓形虫病的治疗尚无特效药物，主要以乙胺嘧啶，乙酰螺旋霉素等药物为主，这些药物对速殖子有杀灭、抑制作用，而对包囊内的缓殖子几乎没有作用。

There were not specific medicine to toxoplasmosis , the drugs , such as pyrimethamine , acetyl spiramycin , et al , are used widely to treat toxoplasmosis , but the drugs only kill or depress tachyzoite , do not affect bradyzoites in the tissue cyst .