snac

Methods To determine the enhancement effect of SNAC on INS absorption by oral administration to rats and mice ;

方法小鼠和大鼠灌胃给药考察SNAC对INS溶液的吸收促进作用；

The extent of LMWH intestinal absorption promoted by NE-Imw was corresponded to that of SNAC carrier .

NE-Imw促LMWH肠吸收程度与载体SNAC相当。

Conclusion The enhancement of SNAC to INS absorption presented dose dependence on SNAC ; the absorption process needed energy and related to P-gp efflux .

结论SNAC对INS的吸收促进作用呈剂量依赖，需要能量，受P糖蛋白排放影响。

In addition , co-administrated with SNAC , casein and protamine , INS enteric-microspheres had a longer and more potent hypoglycemic effect than that of the solution .

在SNAC、鱼精蛋白和酪蛋白存在下，INS肠溶微球比INS溶液有更强而持久的降血糖作用。

Moreover , intraduodenal administration to rats of the first sort of microemulsion , into which low amount of SNAC was evenly incorporated , was observed to result in significant hypoglycemic actions and longer duration .

大鼠十二指肠给药时，微乳A中加入低剂量的SNAC就可以显著增加其降糖作用，并延长作用时间。

The drug loading of insulin enteric-microspheres was about 7 % . In vivo experiment , chitosan-cysteine conjugate ( 85 mg · kg - 1 ) prolonged the hypoglycemic time of insulin solution or enteric-microspheres when administered simultaneously with the absorption enhancer SNAC .

所制备的胰岛素肠溶微球载药量7%，大鼠灌胃给予壳聚糖&半胱氨酸轭合物85mg·kg-1，可增强胰岛素溶液或肠溶微球的口服降血糖作用。