s1p

Role of the SPK / S1P signal in the expression of VEGF in human hepatoma cells

SPK/S1P信号途径对人肝癌细胞VEGF表达的作用

The combined tumorigenic and angiogenic effects of S1P make it an excellent target for anticancer therapy .

其致瘤和促血管生成的双重作用使得S1P成为一个作为抗癌治疗非常好的靶点。

This article intends to provide a review about the function of S1P in PIRI , based on published data recently .

本文基于近年来的研究进展，对S1P在PIRI中的作用进行综述。

It is difficult to find an area of physiology and pathophysiology in which S1P does not have important if not key roles .

很难发现生理学和病理生理学领域中S1P不起重要作用，即使不是关键作用。

Results 1.The effects of SPK1 / S1P signal on survival in human hepatocellular carcinoma MDR cell strain BEL-FU .

结果1.SPK1／S1P信号途径对人肝癌耐药细胞株BEL-FU凋亡的影响。

S1P has a pivotal role in cell proliferation , migration , apoptosis , and involves in some physiological and pathological progress of cardiovascular system , immune system and et al .

S1P通过调节和参与细胞增殖、迁移、凋亡等机制，参与到生物体内心血管、免疫等系统的诸多重要生理和病理过程。

S1P improves the increase in the microvessel permeability caused by PAF , which might be mediated by strengthening adherent junction and inhibiting the formation of endothelial gaps .

S1P能改善PAF引起的血管通透性增高，其作用与加强内皮细胞间粘附连接，抑制细胞间隙打开有关。

Sphingosine kinase ( SPK ) is a key enzyme catalyzing the formation of sphingosine 1 phosphate ( S1P ), which is a lipid messenger with strong angiogenic activity .

细胞内鞘氨醇激酶（SPK）是催化鞘氨醇生成1-磷酸鞘氨醇（S1P）的限速酶。

Aim : To establish the methods for determining the activity of sphingosine kianse ( SPK ) and the content of sphingosine 1-phosphate ( S1P ) in biological samples .

目的：建立生物样品中鞘氨醇激酶（SPK）活性和1-磷酸鞘氨醇（S1P）含量的测定方法。