lef

Clinical Research of LEF in Treating 40 Cases of Chronic Glomerulus Disease

来氟米特治疗慢性肾小球疾病40例临床研究

The following figure shows a LEF standard cell with shapes similar to layout data .

下面的图展示了LEF标准单元和形状类似的布局数据。

AIM To study the tolerance of Leflunomide ( Lef ) in normal Chinese .

目的研究正常国人对来氟米特（Leflunomide，Lef）的耐受程度。

Conclusion : LEF is an effective agent for treatment of RA with better tolerability .

结论：LEF治疗RA的疗效肯定，且具有较好的耐受性。

Why didn 't he close the window when he lef ... ?

他离开时为何不关上窗子呢

Theory of the reaction surface with lef ≠ 1 and its application to investigation of OXIDATION-SUBLIMATION coupling process

具有Lef≠1的反应面理论及其在氧化-升华耦合过程研究中的应用

CONCLUSION Lef has significantly preventive action on CCl4-induced liver fibrosis possibly mediated by reduction of NO.

结论Lef对实验性肝纤维化预防作用可能是通过降低NO的水平，进而降低细胞毒作用和纤维化进程而产生的。

Secondly , a new algorithm based on the nonlinear least squares method for estimating LEF and factor C in SLs is proposed .

其次，本文提出了新的基于自混合干涉效应的半导体激光器线宽展宽因数的最小二乘测量算法。

The link equipment failure procedure ( LEF ) operation detects link failures and notifies concerned parties about them .

链路设备故障过程（LEF）操作检测链路故障并通知与之有关的各方。

Objective : To explore the curative effect and side effect of Lefluwomide ( LEF ) in treating chronic glomerulus disease .

目的：探讨来氟米特（LEF）治疗原发性肾小球疾病的疗效及副反应。

Pancreatic islet xenotransplantation with immunosuppressive drugs FK506 and LEF

异种胰岛移植联合应用免疫抑制剂FK506和LEF的实验研究

AIM To observe the preventive action of leflunomide ( Lef ) on CCl4-induced liver fibrosis and explore its mechanism .

目的观察来氟米特（Lef）对四氯化碳（CCl4）诱导的肝纤维化的预防作用，并对其机制进行探讨。

Lef / Tcf-dependent Wnt / b-catenin Signaling Pathway and Xenopus Early Development

Lef/Tcf依赖的Wnt/β-catenin信号通路与爪蟾的早期发育

After two years treatment , the total efficiency rate of LEF group was 89.7 % , which was a little higher than that of MTX group ( 82.1 % ) .

治疗满2年时，MTX维持治疗组的显效率和总有效率分别为57.1%和82.1%。

All measures were lower in the LEF group than that of MTX + LEF group , but there were no statistical significance . 3 .

MTX+LEF组的各项具体指标均高于LEF组，但未达到统计学差异。

Objective To evaluate the efficacy and safety of leflunomide ( LEF ) in induction and maintenance therapy of type ⅳ and type ⅴ lupus nephritis .

目的观察来氟米特诱导和维持治疗Ⅳ型及Ⅴ型狼疮肾炎（LN）的疗效及安全性。

Conclusion Both FK506 and Lef can suppress proliferation of CD4 + T-cells and prevent or delay islet xenograft rejection .

结论FK506与Lef通过抑制CD4+T淋巴细胞的增殖而阻止或延缓异种胰岛移植的急性排斥反应。

Conclusions : TGP combined with LEF can delay the progression of RA and provide protection for sclerotin and synovium of joint .

结论：TGP联合LEF治疗RA能稳定病情，对关节滑膜及骨质破坏起到较好的保护作用。

Objective To assess the preventive effects of FK506 and Leflunomide ( Lef ) on islet xenograft acute rejection in rat-to-mouse models .

目的研究他克莫司（FK506）和来氟米特（Lef）对异种胰岛移植后急性排斥反应的抑制作用。

The improvement in the LEF group was significant lower than that in the MTX and MTX + LEF group at week 24 ( P0.05 ) . 5 .

24周的改善程度LEF组低于MTX组和MTX+LEF组，差异有显著统计学意义（P＜0.05）。

RESULTS : The extract of LEF could significantly augment the percentage of activated macrophage , phagocytic activity and the percentage of cell-membrance receptor Fc of macrophage .

结果：地龙能显著地提高巨噬细胞活化率、细胞表面Fc受体功能增强、提高其吞噬中性红的能力。

Splenectomy has synergistic immunosuppressive effect with Lef to decrease the serum IgG levels and the IgG deposition in the xenograft and effectively prolongs the xenograft survival .

脾切除和具有协同免疫抑制作用，可降低移植后受体血清水平及移植物中沉积，延长异种移植物LefIgGIgG的存活时间。

Conclusion : LEF had the same efficacy as TW in the LN maintenance therapy in those follow-up ≥ 6 months patients , and it had weak effect on menses .

结论：在维持治疗超过6个月的患者中，LEF维持治疗的疗效与TW相当，对月经的影响明显低于TW组。

Objective : To assess clinical efficacy in rheumatoid arthritis ( RA ) patients with 3-month leflunomide ( LEF ) therapy , comparing with methotrexate ( MTX ) .

目的：通过II期随机对照临床试验比较研究药物来氟米特（LEF）和阳性对照甲氨喋呤（MTX）治疗类风湿关节炎（RA）临床疗效和安全性，旨在科学地评价LEF在治疗RA中的作用。

Methods The IL-2R express level in 19 active SLE patients and 20 healthy donor was measured by SPA , and analysis the changes of IL-2R express before and after the LEF treatment .

方法采用SPA免疫酶联法测定了19例活动性SLE患者IL-2R表达，并观察LEF治疗前后IL-2R表达的变化。

Identifying Viable Myocardium With Different Low-Dose Dobutamine Echocardiography Compared With ~ ( 18 ) F-Fluorodeoxyglucose Single Photon Emission Computed Tomography Myocardial Metabolic Image in Patients With Myocardial Infarction and Severe Lef

不同小剂量多巴酚丁胺超声心动图与~（18）F-脱氧葡萄糖心肌代谢显像对比检测冠心病左心室收缩功能严重受损患者存活心肌

Objective To Validte the Yeliabil of left ventricle ejection fraction ( LEF ) measured by reconstructed impedance cardiography ( RICG ) .

目的验证重建心阻抗图测量左室射血分数（LEF）的可靠性。

The levels of IL-2 in the peripheral blood of tacrolimus + Lef group is lower than that of tacrolimus group and Lef group 7 days after transplantation ( P < 0.05 ) .

术后7d，外周血IL-2水平联合用药组明显低于单独用药组（P<0.05）。

The caveolin may functionally regulate the activation state of caveolae-associated signaling molecules , and have the interaction with APC - - catenin-Tcf / Lef signaling .

小窝蛋白（caveolin）对多种信号分子起调控作用，并与APC-β-catenin-Tcf/Lef通路之间存在相互作用。

In LEF and NEF groups , impaired glucose tolerance coexisted with exceptional strong insulin response to glucose load . and the response in LEF group was stronger than that in NEF group .

LEF、NEF两组糖耐量受损与异常增高的胰岛素释放反应并存，LEF组胰岛素释放反应强度大于NEF组；