holoenzyme

Objective Identifying telomere associated proteins in order to make experimental basis for understanding the structure of telomerase holoenzyme and its biological function .

目的筛选、鉴定新的人端粒相关蛋白，为进一步了解端粒酶全酶的结构、生物学功能及其作用机制奠定实验基础。

The Structural Investigation of the HIV-1 Integrase Holoenzyme and the Screening of Its Inhibitors

HIV-1整合酶全酶结构模拟及其抑制剂筛选

The holoenzyme recognizes specific nucleotide sequences on the DNA duplex ( promoters ) .

全酶还能识别DNA双链分子上的特定核苷酸序列（起动基因）。

Bacteria can use alternative sigma factors , which direct the RNA polymerase holoenzyme to a specific class of promoters , to adapt to environmental changes .

细菌可以利用选择性σ因子引导RNA聚合酶全酶结合到特殊类别的启动子上来调控基因的表达，从而使细菌适应环境的变化。

This study was to search specific CK2 inhibitors in tumor cells through observation of the inhibitory effects of baicalein on recombinant human protein kinase CK2 holoenzyme and its kinetics in vitro .

为了寻找肿瘤细胞内CK2的特异性抑制剂，本研究观察黄芩甙体外对重组人蛋白激酶CK2的抑制效果，并进行酶动力学分析以确定其抑制作用类型。

However , fully denatured Rubisco subunits still could not be reassembled into holoenzyme after gradual dialysis unless chaperonin 60 ( cpn60 ) was added .

然而，仅仅通过分步透析除去变性剂，Rubisco的亚基仍然不能重组成全酶，除非再加入分子陪伴蛋白60（cpn60）。

Cyclin D1 encodes the regulatory subunit of a holoenzyme that phosphorylates and inactivates the retinoblastoma protein and promotes progression through the G1-S phase of the cell cycle .

周期素D1编码一种全酶的调节亚单位，该酶利用蛋白磷酸化灭活视网膜母细胞瘤蛋白，通过细胞周期G1-S期促进肿瘤进展恶化。

At present , there are 26 crystal structures of HIV-1 integrase in the protein data bank , which include single domain or two domains of it , but none of them is the holoenzyme structure of HIV-1 integrase .

目前蛋白质数据库（ProteinDataBank，PDB）中有26个关于HIV-1整合酶的晶体结构，但仅仅是包含整合酶的单个结构域或其中的两个结构域，无整合酶全酶的晶体结构。