Adverse events were graded according to Common Terminology Criteria for Adverse Events version 3.0 ( CTCAE v3.0 ) . Primary end points were determined by dose-limiting toxicity ( DLT ) .
治疗相关不良反应按国际常见不良反应标准第3版（CTCAEv3.0）分级，出现剂量限制毒性（dose-limitingtoxicity，DLT）为观察终点。
ctcae