aqp4

Objective To examine the distribution and expression of AQP4 in normal rabbits spinal cord so as to provide theoretical basis for futher study spinal water transport and balance regulation .

目的明确正常兔脊髓水通道蛋白-4（AQP4）的表达分布规律，为进一步研究脊髓组织中水分子的运输及平衡调节提供理论依据。

The results suggest that AQP4 plays an important role in the early stage of the hypertonic dehydration .

AQP4可能在高渗性脱水的早期起重要的调节作用。

The results showed : AQP4 : Normally a faint expression , express increased significantly after cerebral ischemia .

结果显示：AQP4：正常情况下微弱表达，脑缺血后表达明显升高。

To explore the mechanism and role of AQP4 and DFO in edema formation after ICH .

以期阐明AQP4及DFO在脑出血后水肿形成中的机制及作用。

Conclusion Decreased AQP4 expression in COPD patients may be one of the causes of weakened lung function and worsened air tube inflammation .

结论COPD患者AQP4表达减少可能是其肺功能下降及气道炎症加重的原因之一。

Objective To investigate the relationship between aquaporin-4 ( AQP4 ) water channel expression in astrocytes and brain edema caused by glioma .

目的研究脑胶质瘤细胞对体外血脑屏障模型水转运及星形胶质细胞水通道4的影响。

Objective To investigate relation between expression changes of aquaporin 4 ( AQP4 ) and brain edema after explosive brain injury in rats .

目的研究大鼠颅脑爆炸伤后水通道蛋白4（aquaporin4，AQP4）表达变化及其与脑水肿的关系。

Objective To study the expression of aquaporin-4 ( AQP4 ) and its pathologic effect on brain edema after hematoma formation in rats .

目的研究大鼠脑出血（ICH）后皮质、CPu血肿周围组织水孔蛋白-4（AQP4）表达的变化，以探讨其在脑水肿形成过程中的作用。

ResultsThe results of immunoblotting and immunofluorescence showed no AQP4 expression in the olfactory system in AQP4-null mice .

结果免疫荧光和免疫印迹结果均证实了AQP4基因敲除小鼠嗅觉系统中没有AQP4的表达。

The level of brain water content 、 IL-8 content 、 AQP4 immune expression intensity was decreased and ion content disorder was improved after Aprotinin administration .

抑肽酶能够显著的降低AQP4表达水平、脑水含量、IL-8含量的水平。

Objective To observe the expression of aquaporin-4 ( AQP4 ) in inflammatory brain edema by injecting endotoxin into infant rats .

目的观察内毒素致幼年大鼠感染性脑水肿后脑组织水通道蛋白4（AQP4）表达的变化。

Objective To study the dynamic changes of AQP4 mRNA expression and Brain water content ( BWC ) between ICH models and DFO intervention models .

目的观察水通道蛋白4（AQP4）及脑水含量在脑出血模型组及去铁胺（DFO）模型干预组的动态变化。

Subsequently , aquaporin-4 ( AQP4 ), the most abundant water channel in the CNS , was identified as its target antigen .

接着，中枢神经系统中最丰富的水通道，水通道蛋-4（AQP4）被确定为它的靶抗原。

Objective To study the relationship between the expression of aquaporin-4 ( AQP4 ) and cerebral edema formation during the pathologic course of hemorrhagic cerebral edema .

目的研究出血性脑水肿病理过程中水通道蛋白4（aquaporin4，AQP4）的表达与脑水肿形成之间的关系。

Objective To clone AQP4 gene and construct its expression vector in order to study the function of AQP4 in cerebral water metabolism in the rat by genetic intervention .

目的克隆大鼠AQP4基因并构建其融合蛋白表达载体，以便载体在体内进行AQP4基因干预。

MethodsThe differences of AQP4 expression in olfaction system between wild-type and AQP4-null mice were studied by immunoblotting and immunofluorescence methods .

方法应用免疫荧光和免疫印迹技术研究野生型和AQP4基因敲除小鼠嗅觉系统中AQP4的表达差异；

Expression of AQP4 in the brain at the early period of cerebral ischemia reperfusion injury was increased after injection of APQ4 gene into the rat brain .

脑内注射AQP4基因后可升高大鼠脑缺血再灌注损伤早期脑内AQP4的表达水平。

AIM : To investigate whether aquaporin-4 ( AQP4 ) participates in the regulative action of estrogen on neurotransmitters ( NT ) .

目的：探讨AQP4对雌激素调节神经递质作用的影响。

Aim : To explore the method for high throughput drug screening searching for Aquaporin 4 ( AQP4 ) inhibitor and develop a new therapeutic approach to treat brain edema .

目的：探讨星形胶质细胞形态学观察在高通量药物筛选水通道蛋白4（AQP4）抑制剂中的应用，为脑水肿和其他水转运障碍疾病的治疗提供理论依据。

AIM : To study the relationship between piwei damp-heat syndrome and aquaporin 4 ( AQP4 ) from fluid metabolism in patients with chronic superficial gastritis .

目的：从水液代谢来研究慢性浅表性胃炎脾胃湿热证与AQP4表达的关系。

AQP4 expresses mainly on squamous epithelial , pseudostratified ciliated columnar epithelium , laryngeal lamina propria mucous glands and myocyte membrane .

AQP4主要表达于大鼠喉黏膜鳞状上皮、假复层柱状纤毛上皮、固有层黏膜腺体及肌细胞膜上。

Conclusion : The increasing of expression of AQP4 In the rat brain results from acute alcoholism , which may be related with the occurrence of cerebral edema in the acute alcoholism .

结论：急性酒精中毒能使大鼠脑内AQP4表达显著增加，其表达的变化可能与急性酒精中毒时脑水肿有关。

Conclusions AQP4 may play a key role in edema formation and absorption after ICH , DFO was likely to be a new effective agent to intervene brain edema formation after ICH .

结论AQP4在ICH后水肿的形成及消退中可能起重要作用，DFO可能对干预ICH后水肿形成有一定作用。

Objective To study the effect of mild hypothermia on aquaporin 4 ( AQP4 ) expressions and cerebral edema after intracerebral hemorrhage and the mechanisms of mild hypothermia on hemorrhagic brain edema .

目的研究亚低温对脑出血后水通道蛋白4（AQP4）表达及脑水肿的影响，探讨亚低温对出血性脑水肿的作用机制。

Objective To observe the effect of Panax Notoginseng Saponins ( PNS ) on expression of aquaporin-4 ( AQP4 ) and brain edema after intracerebral hemorrhage ( ICH ) in rats .

目的观察三七总皂甙对脑出血大鼠脑水肿形成及水通道蛋白-4（AQP4）表达的影响。

A reported impact-acceleration head injury model was used . The immunoreactivity of endothelial barrier antigen ( EBA ) and aquaporin-4 ( AQP4 ) in injured brains were assessed by immunohistochemistry .

在大鼠重度冲击加速性伤模型中，应用免疫组化法观察脑创伤灶中内皮屏障抗原（EBA）和Ⅳ型水通道蛋白（AQP4）免疫反应性在不同时点的动态改变。

AIM : To investigate the changes of aquaporin 4 ( AQP4 ) expression in the brain tissue of rat models of cerebral edema in the stimulating surroundings of 5 000 m highland , and study its significance .

目的：探讨大鼠在模拟5000m高原环境下脑水肿脑组织水通道蛋白4（aquaporin4，AQP4）的表达变化及意义。

Objective To observe the immunolocalization of Aquarorin-4 ( AQP4 ) in testis and epididymis of rat , so as to provide morphological basis for studying the function of AQP4 in testis and epididymis .

目的观察水通道蛋白-4（AQP4）在雄性大鼠睾丸和附睾的表达及分布特点，为探讨水通道蛋白在睾丸和附睾中的作用提供形态学基础。

Objective : The aim of this study was to investigate the rule of aquaporin-4 ( AQP4 ) and aquaporin-9 ( AQP9 ) expression in the stage of brain edema after severe bum and to clarify the cause of brain edema .

目的：探讨水通道蛋白-4（AQP4）和水通道蛋白-9（AQP9）在严重烧伤后脑水肿过程中的表达规律，以阐明烧伤后脑水肿的发生机制。

Aquaporin-4 ( AQP4 ) is an important structural basis for water regulation and trans - portation in the central nervous system , which participates in physiopathological processes , such as cerebrospinal fluid reabsorption , osmotic regulation , and cerebral edema formation .

水通道蛋白4（AQP4）是中枢神经系统水调节和运输的重要结构基础，参与脑脊液重吸收、渗透压调节、脑水肿形成等生理和病理学过程；