Uuo

Six rats of each group were killed respectively at 1,4,7,10,14 days after UUO .

于术后第1，4，7，10，14天分别处死各组大鼠。

Low estrogen group ( rats were ovariectomized and underwent UUO );

低雌激素组（UUO+OVX）；

[ Conclusion ] Oxidation stress contributes in UUO induced renal interstitial fibrosis .

结论单侧输尿管梗阻可以诱导大鼠肾间质纤维化，氧化应激参与肾间质纤维化的形成。

High estrogen group ( rats underwent UUO and received 17 β - estradiol injection ) .

高雌激素组（UUO+E2）。

Protective Effect of Recombinant Human Erythropoietin in Renal Tubulointerstitial Fibrosis with UUO in Rat

重组人红细胞生成素改善UUO大鼠肾脏纤维化的研究

The models were established by unilateral ureteral obstruction ( UUO ) of the left side .

以单侧输尿管结扎术建立输尿管梗阻的动物模型。

Conclusion Adrenomedullin play an important role in the process of cell proliferation in renal interstitial pathological changes by UUO .

结论肾上腺髓质素在UUO介导的肾间质病变的细胞增殖过程中有着重要的作用。

Retinoic acid reduced RANTES and tubulointerstitial inflammation of UUO rats

维甲酸对UUO大鼠肾组织RANTES表达及炎症反应的影响

Effect of 1 , 25 ( OH ) _2D_3 on interstitial fibrosis in UUO rats

1,25（OH）2D3对大鼠单侧输尿管梗阻肾组织核因子κB表达的影响及意义

Methods : Complete unilateral ureteral obstruction ( UUO ) models were produced in rats by left ureteral ligation .

方法：建立大鼠单侧输尿管梗阻（UUO）模型。

The Expression and Significance of Tissue Transglutaminase at the Stage of Tubulointerstitium Lesions in Kidney from UUO Young Rats

组织型转谷氨酰胺酶与转化生长因子β1在幼鼠肾间质损伤中的表达及意义

Effect of endothelial progenitor cells transplantation on reconstitution of peritubular capillares in UUO rats

内皮祖细胞移植对单侧输尿管梗阻大鼠肾小管周毛细血管重建的影响

Expression of platelet-derived growth factor-BB and CD68 positive cell in renal interstitial tissues of rats with UUO

血小板衍生生长因子与CD68在单侧输尿管结扎大鼠肾间质中的表达及意义

Conclusion : Rosiglitazone can suppress oxidative stress in rats with UUO by reducing lipid peroxidation production and improving antioxidative enzyme contents .

结论：RSG能减少单侧输尿管梗阻侧肾皮质脂质过氧化物的产生，同时增加抗氧化酶的含量，从而改善单侧输尿管梗阻大鼠氧化应激。

In addition to the normal group , UUO model were made by slicing on back and ligating the right ureter after anaesthesia .

除正常组外均造成UUO模型，即麻醉后背部切口，结扎右侧输尿管。

Expression and implication of tissue transglutaminase and connective tissue growth factor at fibrotic tubulointerstitium in kidneys from UUO rats

肾间质纤维化组织中组织型转谷氨酰胺酶和结缔组织生长因子共表达

The effect of mycophenolate mofetil on the expression of MCP-1 and TGF - β _1 in UUO rats

霉酚酸酯对UUO大鼠肾间质MCP-1和TGF-β1表达的影响

Objective To observe the effect of PI3K / AKT signal passageway on renal tubulointerstitial fibrogenesis of UUO rats .

目的探讨PI3K/AKT信号通路是否参与肾间质纤维化的发病过程。

UUO group rats received an operation with left ureteral obstruction below the renal pelvis and were also gavaged with saline daily ;

单侧输尿管梗阻组（U）：大鼠行手术剖腹，分离并于肾盂下结扎左侧输尿管，同时术前一天开始每日给以安慰剂生理盐水灌胃处理；

Objective To investigate the ameliorating effect of sodium ferulate on renal lesion in rats with unilateral ureteral obstruction ( UUO ) .

目的观察阿魏酸钠（SF）对单侧输尿管梗阻（UUO）大鼠肾脏损害的改善作用。

Effect of benazeprile on renal interstitial inflammatory cell infiltration was observed in rats with unilateral ureteral obstruction ( UUO ) .

应用苯那普利对鼠单侧输尿管梗阻（UUO）的肾间质炎性细胞浸润的作用进行观察。

Objective To observe the renal expression of cyclooxygenase ( COX ) in the rats with unilateral ureteral obstruction ( UUO ) .

目的观察环氧合酶（COX）的两种同工酶，即COX1和COX2在单侧输尿管梗阻（UUO）大鼠术侧肾脏的表达情况。

Rats in the model group and treatment group were treated by UUO , while rats in the sham-operation group were only liberate the ureter without deligation .

模型组与阿乐组大鼠均行单侧输尿管梗阻术，假手术组仅游离输尿管但不结扎。

AIM : To observe the roles of rosiglitazone ( RSG ) in unilateral ureteral obstruction ( UUO ) rats renal interstitial fibrosis .

目的：探讨罗格列酮（RSG）对单侧输尿管梗阻（UUO）大鼠肾间质纤维化的保护作用及其机制。

Conclusions The animal model of UUO by inserting tube into ureter was established successfully , it was easy to collect of urine repeatedly in this modle .

结论采用输尿管内置管建立的梗阻动物模型，易于进行标本的反复收集；

Synthetical control of noise for the measure ships Effect of Gypenosides on Expression of Connective Tissue Growth Factor ( CTGF ) in UUO Rats with Renal Tubulointerstitial Fibrosis

绞滩船绞机绞股蓝总皂苷防治单侧输尿管结扎大鼠肾间质纤维化的实验研究

Objective : To study the influence of total salvianolic acid ( TSA ) on the renal interstitial fibrosis caused by unilateral ureteral obstruction ( UUO ) in rats .

目的观察丹参总酚酸对单侧输尿管梗阻（UUO）大鼠肾间质纤维化的影响。

Conclusions Expression and functional activation of Rock ⅰ enhance in renal tissue from UUO rats . Rho / Rock signaling may play an important role in the progression of RIF .

结论UUO大鼠肾组织中存在小G蛋白Rho相关激酶Rock-Ⅰ的表达上调与功能活化，提示Rho/Rock信号转导通路在肾间质纤维化的发生机制中具有重要作用。

[ Objective ] To evaluate the effect of estrogen on tubular epithelial cell phenotype transdifferentiation of tubulointerstitial fibrosis in unilateral ureteral obstruction ( UUO ) rats .

目的探讨雌激素在单侧输尿管梗阻（UUO）大鼠肾间质纤维化模型中对肾小管上皮细胞表型转化的影响。

Conclusion The pharmacological effects of curcumin and enalapril may be partly mediated by inhibiting the transdifferentiation of renal tubular epithelial cells towards myofibroblast in UUO rats .

结论姜黄素及依那普利可能通过抑制UUO大鼠肾小管上皮细胞转分化而减轻肾间质纤维化。