MDSCs

Effects of Exogenous bFGF and CNTF on the Proliferation of MDSCs of Rat

外源性bFGF和CNTF对大鼠MDSCs增殖的影响

The collagen mimic the microenvironment prompt the rats the MDSCs differentiating into islet-like cells .

结论1、胶原支架可模仿细胞发育的微环境，促使大鼠MDSCs跨分化为胰岛样细胞。

Among these suppressor cells , myeloid derived suppressor cells ( MDSCs ) have become a hotspot in the research of tumor-induced immune tolerance .

髓系来源抑制性细胞（MDSCs）就是这些免疫抑制细胞中的一种，并成为肿瘤诱导的免疫耐受的研究热点。

Conclusions The tissue engineering bladder constructed by MDSCs and PBAM can be used as an ideal biomaterial to replace and repair the bladder .

结论采用MDSC及PBAM构建的组织工程膀胱是理想的膀胱替代修补材料。

Recently , myeloid derived suppressor cells ( MDSCs ) have been found to accumulate in trauma host and can be induced by glucocorticoid in vitro .

近来，人们在创伤小鼠模型中发现大量髓源性免疫抑制细胞（MDSCs）扩增，同时体外实验中发现糖皮质激素能诱导MDSCs扩增。

The percentage of CD11b + / Gr-1 + MDSCs in spleen , peripheral blood and bone marrow was determined by flow cytometry or immunohistochemistry .

以流式细胞术和免疫组化检测脾脏、外周血和骨髓中CD11b+/Gr-1+MDSCs的比例。

Urodynamic test was used to measure leak point pressure ( LPP ) and maximal bladder capacity at 1 ~ st week and 2 ~ nd week after MDSCs transplantation .

尿动力学仪检测MDSCs移植后1、2周的漏尿点压力（leakpointpressure，LPP）和最大膀胱容量。

It is reported that MDSCs are elevated in peripheral blood and tumor tissues of cancer patients and also in bone marrow , spleen , blood and tumor tissues of tumor-bearing mice .

研究发现，MDSCs在癌症患者的外周血以及荷瘤小鼠的骨髓、血液和脾脏中显著增加，肿瘤组织中也有浸润。

Sorted the MDSCs from splenic mononuclear cells of Lewis lung carcinoma bearing mice at early and late tumor bearing stages or normal mice by utilizing immunomagnetic beads . 3 .

利用相应的免疫磁珠分选早、晚期Lewis肺癌荷瘤小鼠及正常小鼠脾脏中的MDSCs。

Myeloid derived suppressor cells ( MDSCs ) are a heterogeneous population of cells that expands during cancer , inflammation and infection , and that has a remarkable ability to suppress T-cell responses .

骨髓来源抑制细胞（MDSC）是一组具有高度异质性的细胞群，它可在肿瘤、炎症、感染等疾病中异常升高，并具有显著的抑制T细胞的功能。

Objective : 1 . To investigate the methods about the segregation , purification , cultivation and identification of Muscle-derived Stem Cells ( MDSCs ) in vitro , especially , to study the cells ' biological characters .

目的：1.探讨骨骼肌源性干细胞体外分离纯化、培养、鉴定的方法，研究骨骼肌源性干细胞的生物学特性，为后续的实验奠定基础。

Conclusion MDSCs could survive and differentiate after transplanted into proximal urethra of SUI rats and could improve function of sphincter muscle of urethra , suggesting that MDSCs transplantation may be an effective method to treat SUI .

结论MDSCs移植后能存活并分化而整合至尿道括约肌，尿道括约肌功能得到改善，提示MDSCs移植可能是治疗压力性尿失禁的有效方法。

During tumor progression , a variety of cytokines such as GM-CSF , M-CSF , IL-3 , IL-6 , and VEGF are produced to prevent myeloid differentiation and result in expansion and accumulation of MDSCs , and it will be detrimental to anti-tumor immunity .

在肿瘤进展过程中，能产生多种细胞因子如GM-CSF、M-CSF、IL-3、IL-6及VEGF等导致MDSCs分化受阻、扩增、聚集，这将不利于机体的抗肿瘤免疫。