酮康唑

两性霉素B和制霉菌素、酮康唑和克霉唑都是已知的作用机制类似的抗真菌药物。

Amphotericin B and nystatin , ketoconazole and clotrimazole have been known to have similar antifungal mechanism respectively .

HPLC测定复方酮康唑洗剂中两组分的含量

Determination of Two Components of Compound Ketoconazole Lotion by HPLC

目前临床上常用的抗真菌药物主要有两性霉素B，酮康唑，氟康唑，泊沙康唑、卡泊芬净等。

At present , amphotericin B , ketoconazole , fluconazole , posaconazole , caspofungin are the most common antifungal agents .

HPLC法测定复方酮康唑乳膏的含量

Determination the Contents of Ketoconazole and Clobetasol Propionate in Compound Ketoconazole Cream by RP-HPLC

HPLC法测定乳膏剂中的酮康唑含量

Assay of Ketoconazole Cream by HPLC

体外药敏试验显示对伊曲康唑、两性霉素B、制霉菌素高度敏感，酮康唑、克霉唑低度敏感，氟康唑耐药。

The drug sensitive test in vitro indicated that itraconazole , amphotericin B and nystatin were highly sensitive , ketoconazole and clotrimazole were low sensitive , fluconazole was resistant .

方法：用旋转蒸发法制备酮康唑传递体，反相HPLC法测定酮康唑的含量。

Methods : The rotary evaporation method was used for preparation of KCZ TF . The HPLC was employed in its determination .

建立了HPLC法同时检测洗发水中违禁氟康唑、酮康唑、特康唑和硝酸咪康唑的含量。

A HPLC method was established for the simultaneous determination of fluconazol , ketoconazole , terconazole and miconazole nitrate in illegal shampoo .

方法：将真菌性角膜溃疡患者30例分为氟康唑组（n＝16）和酮康唑组（n＝14），比较组间的治愈率和平均疗程。

Methods : 30 cases of fungal keratitis were divided into fluconazole group ( 16 cases ) and ketoconazole group ( 14 cases ) with corresponding drug used .

结果：检测出的念珠菌对特比萘芬耐药，对氟康唑、酮康唑、咪康唑、克霉唑中度敏感，对制霉菌素、伊曲康唑、两性霉素B、氟胞嘧啶高度敏感。

Result : Candida species are resistant to terbinafine , medium susceptible to fluconazole 、 ketoconazole 、 miconazole and clotrimazole , high susceptible to nystatin 、 itraconazole 、 amphotericin B and flucytosine .

RP-HPLC法同时测定复方酮康唑乳膏中二组分的含量及有关物质检查

Simultaneous assay and determination of related substances of ketoconazole and clobetasol propionate in the Compound Ketoconazole Cream by RP-HPLC

结论：酮康唑可能通过降低VEGF水平而发挥治疗OHSS的作用。

CONCLUSION : Ketoconazole may play its role in treating OHSS by reducing the expression of VEGF .

目的：观察酮康唑对大鼠肝细胞色素P450及其主要亚型的影响。

Objective : To assess the effects of ketoconazole on rat cytochrome P450 and its main subtypes .

目的：观察酮康唑对卵巢过度刺激综合征（OHSS）模型大鼠血管内皮生长因子（VEGF）及肿瘤坏死因子（TNFα、TNFβ）的影响。

OBJECTIVE : To observe the effects of ketoconazole on VEGF and TNF α, TNF β in rat models with ovarian hyperstimulation syndrome ( OHSS ) .

将马拉色菌阳性的82例慢性荨麻疹患者分为A、B两组，A组单用抗组胺药，B组用抗组胺药联合2%酮康唑洗剂治疗。

The 82 urticaria patients identified as positive for Malassezia furfur were divided into groups A and B to receive treatment with antihistaminics ( group A ) and antihistaminics combined with 2 % ketoconazole shampoo ( group A ) .

P-gp的标准底物维拉帕米在模型中的外排能被P-gp的强抑制剂酮康唑抑制。

The efflux of the standard substrate of P-gp verapamil could be effectively inhibited by ketoconazole , the potent inhibitor of P-gp .

7例急性白血病缓解期患者（男性4例，女性3例；平均年龄29±9a），因真菌感染服用酮康唑0.2g，bid。

Seven patients with acute leukemia and fungal infection were given ketoconazole 0 . 2g bid for 1 wk .

酮康唑对大鼠肝脏CYP450酶系的影响

Effects of ketoconazole on rat liver cytochrome P450

采用C18反相色谱柱，利用在流动相中加入手性选择剂的方法实现酮康唑对映体的拆分。

A simple and effective method for the separation of ketoconazole enantiomers was developed using the chiral mobile phase additive on a C18 reversed-phase column .

B组为对照组，30例（男性20例，女性10例，年龄47a±25a）用复方酮康唑软膏治疗。

Group B of 30 patients ( M 20 , F 10 , age 47 a ± 25 a ) was treated with compound ketoconazole ointment .

治疗组初次治疗为：阴道应用酮康唑400mg/d，14d巩固治疗，每次月经后口服酮康唑，400mg/d，5d。连用3个月经周期。

The therapy group was treated with 400 mg ketoconazole in vagina for 14 days and 400 mg / d for 5 days after menses for 3 times .

酮康唑（Ketoconazole，KCZ）属于咪唑类抗真菌药物，对深部真菌和浅表真菌感染均有作用。

Ketoconazole ( KCZ ) is an imidazole antifungal agent with a broad spectrum of activity against systemic and superficial mycoses .

结果：治疗结束时，特比萘芬组总有效率为73%（22/30），复方酮康唑组为57%（17/30），P0.05；

The drug effects were evaluated after the treatment . RESULTS : The total effective rates at the end of treatment were 73 % ( 22 / 30 ) for terbinafine group and 57 % ( 17 / 30 ) for compound ketoconazole group ( P 0.05 );

本实验研究了新月弯孢霉细胞色素P450酶与甾体11β-羟基化的关系，选育具有酮康唑抗性标记的氢化可的松高产菌株KA-91，并对其发酵条件工艺优化。

In this paper , the relationship between the cytochrome P450 enzyme and the 11 - hydroxylation of steroids of Curvularia lunata , the screening of high production strain , optimum fermentation process and conditions were studied .

结果：酮康唑、氟胞嘧啶和伊曲康唑对102株白色念珠菌MIC较低，其MIC90分别为0.25μg/ml、0.5μg/ml和0.5μg/ml。两性霉素B和氟康唑MIC90分别为2μg/ml和8μg/ml。

Results : The respective 90 % MICs ( MIC 90 ) of ketoconazole , 5 flucytosine , itraconazole , amphotericin B and fluconazole against 102 isolates of Candida albicans were 0.25 , 0.5 , 0.5,2 and 8 μ g / ml.

方法：将OHSS模型大鼠随机分为酮康唑治疗组、白蛋白阳性对照组、阴性对照组（生理盐水）及刺激组（绒毛膜促性腺激素）。

METHODS : The rat models with OHSS were randomly divided into ketoconazole treatment group , albumin positive group , negative control group ( saline ), and stimuli group ( camisia foetus gonad promoting hormone ) .

特比萘芬软膏与复方酮康唑乳膏治疗浅部真菌病疗效比较

Compare the Effect of Terbinafine on Dermatophytosis with Compound Ketoconazole Cream

酮康唑连续给药对犬肝毒性的病理学观察

Pathological observation on hepatotoxicity of continuous administration of ketoconazole in dog

高效液相层析测定复方酮康唑凝胶中酮康唑的含量

High-performane liquid chromatography in determination of ketoconazole content in co-ketoconazole gel

酮康唑控释片兔体内血药浓度的测定

Determination of Serum Drug Concentration of Ketoconazole Controlled-release Tablet in Rabbits