细胞毒性药物

因释放药物产品，特别是抗生素和细胞毒性药物而导致的中毒和污染；

Poisoning and pollution through the release of pharmaceutical products , in particular , antibiotics and cytotoxic drugs ;

近期未出现感染及其他免疫疾病，未使用激素及细胞毒性药物，无外伤及手术史。

Recently does not appear infection and other immune diseases , without the use of hormones and cytotoxic drugs , no history of trauma and surgery .

细胞毒性药物对肺腺癌A549细胞APE/ref-1表达的影响及其意义

Impacts of Cytotoxic Drugs on APE / ref-1 Expression in A549 Human Lung Adenocarcinoma Cell Line and Its Significance

目的研究细胞毒性药物对A549细胞APE/ref-1表达的影响，初步探讨APE/ref-1与NSCLC耐药性产生的相关性。

Objective To investigate the impacts of cytotoxic drugs on APE / ref-1 expression in A549 cell , in order to find the potential relationship between APE / ref-1 and chemoresistance of NSCLC .

方法：56例肾病综合征患者随机分成治疗组（36例）与对照组（20例），分别应用阿魏酸哌嗪片、激素或细胞毒性药物治疗6mo。

METHODS : 56 patients with nephritic syndrome were randomized into the treatment group ( 36 cases ) and control group ( 20 cases ), to be respectively treated for 6 months with Piperazine Ferulate Tablets , hormones or cell toxic medicines .

目前或在相当一段时期内，传统细胞毒性药物仍将是肿瘤药物治疗的主题。

Traditional cytotoxic drugs play a very important role in drug therapy of cancer .

上海市肿瘤科护士细胞毒性药物安全防护知识及现状调查

Investigation of the practice and knowledge on safe handing of cytotoxic drugs of oncology nurses in Shanghai

接触细胞毒性药物时间与身体健康损害程度呈正比关系。

Results : Times of contacting cytotoxic drugs was positively correlated with damaging degrees of health of nursing staffs .

它们介导着包括细胞毒性药物、类固醇、多肽、磷脂等在内的多类物质的转运。

These transporters mediate efflux of a broad spectrum of substrates including cytotoxic drugs , steroids , peptides and phospholipids .

结论：调查提示护理人员在工作中自身防护意识淡薄，护理人员对细胞毒性药物知识尚缺乏；

Conclusion : The nurses ' self - protection consciousness was weak and lack of knowledge about cell toxic drugs .

随机抽取54名接触多种细胞毒性药物的护理工作人员定期进行健康检查。

Methods : A total of54 nursing staffs contacted various kinds of cytotoxic drugs were selected randomly and health check-up was carried out for them regularly .

结论奥曲肽联合阿司匹林抑制胃癌生长和转移的效果明显优于单用其中任何一种药物，这对临床应用非细胞毒性药物治疗胃癌具有积极的意义。

Conclusion Octreotide combined with aspirin greatly enhanced the anti-growth effect on gastric cancer in vivo when compared to using either of them and inhibited the metastasis of gastric adenocarcinoma in nude mice .

目前化疗的基础药物是细胞毒性药物，但是因其广泛存在的副作用，寻求新的替代性治疗药物成为研究的热点。

In the present period , cytotoxic drugs are the essential drugs in chemotherapy . However , the serious side-effects can not be ignored , to seek new alternative treatments become a research hotspot .

抗癌药物紫杉醇是一种细胞毒性药物，为了降低其毒副作用，增加药物靶向性，本文选用透明质酸作为药物载体与抗癌药物紫杉醇结合，设计新型的药物输送系统。

In order to reduce its toxic side effects and increase drug targeting , we designed a novel drug delivery system , in which hyaluronic acid ( HA ) was used as carrier conjugating with paclitaxel .

结果晚期肺癌患者呼吸道深部真菌感染与肺癌影响，长期应用抗生素、细胞毒性药物，机体免疫力低下等有关。

Results Advanced lung cancer accompanied with fungous infection of lower respiratory tract was related to the effects of advanced lung cancer , long-term application of antibiotics or cytotoxic agent and the degression of immunity in patients .

探讨慢作用药物、细胞毒性药物、非甾体抗炎药、其他药物如反应停、帕米膦酸钠及中药的治疗和治疗策略。

It is important to evaluate the efficacy and strategy of the slow acting anti-rheumatic drugs , cell toxicity drugs , NSAIDs and others such as thalidomide , pamidronate and traditional drugs in the treatment of ankylosing spondylitis ( AS ) .

细胞毒性化疗药物清除MDS恶性克隆，恢复正常多克隆造血，是治疗MDS，尤其是高危组MDS较常用的方法。

Intensive induction chemotherapy in oder to reduce the malignant clone and reconstruct normal hematopoiesis is a classic therapy of MDS , especially high risk MDS .

一般认为细胞毒性化疗药物杀伤或抑制肿瘤细胞的疗效与剂量成正比，呈剂量依赖性关系。

It is thought that cytotoxic drugs inhibit or kill tumor cells in a dose dependent manner .

异烟肼和利福平合用致肝细胞毒性及药物保护机制探讨

Study on the Mechanisms of Hepatotoxicity Induced by Isoniazid and Rifampicin and the Role of Hepatic Protective Drugs

马先蒿属三种药用植物对小鼠肝损伤保护作用的研究异烟肼和利福平合用致肝细胞毒性及药物保护机制探讨

Protection of Pedicularis on Liver Lesion of Mice Induced by Alloxan ; Study on the Mechanisms of Hepatotoxicity Induced by Isoniazid and Rifampicin and the Role of Hepatic Protective Drugs

由于前药本身为低毒性或无毒性，只有被定位于靶部位的酶激活后，才能转化为具有细胞毒性的药物，减低了对正常组织的损伤。

Being of low toxicity or nontoxic , prodrugs do not show cytotoxicity until located on a tumor and activated by an enzyme . The prodrug entering into normal tissue cannot be activated , because of lack of the enzyme , leading to decrease of toxicity .

方法：对28例细胞毒性抗癌化疗药物所致皮肤损伤创面全程采用湿润烧伤膏治疗。

Method : 28 cases of this disease were treated with MEBO in the whole treating course .

前言：目的：观察湿润烧伤膏对细胞毒性抗癌化疗药物所致皮肤损伤的治疗作用。

Objective : To observe the efficacy of MEBO in treating skin lesion caused by cytotoxinic chemotherapeutic agents .

各组复合阿伦磷酸钠骨水泥无成骨细胞毒性，其药物释放浓度在较长时间（至少24周）高于抑制破骨细胞的最小有效浓度。

All alendronate-impregnated bone cement had no cytotoxicity on osteoblasts and their releasing concentration lasted for a long time ( more than 24 weeks ) above minimum effective drug concentration for osteoclasts .

对细胞有毒性作用的药物；一般用于为了制止癌细胞增殖的化学疗法。

Any drug that has a toxic effect on cells ; commonly used in chemotherapy to inhibit the proliferation of cancerous cells .

传统肿瘤化学治疗的主要目的是杀伤癌细胞，但此类细胞毒性药物难以避免选择性差和毒副反应大等缺点。

The main aim of traditional tumour chemical therapy is to kill and wound cancer cells , but this kind of cytotoxicity drugs are hard to avoid weak selectivity , big side effect etc. , shortcomings .

冬凌草甲素是一种对多种肿瘤细胞具有较强抗癌活性的细胞毒性药物，临床资料显示尤其对消化道类肿瘤具有较好的治疗效果，其潜在的生物学效应已经引起广泛关注。

Oridonin , an cytotoxic agent for the treatment of various cancers , especially for gastrointestinal cancer , has been widely attentioned for its promising biological effects .

粒细胞刺激因子（G-CSF）单独或联合细胞毒性化疗药物进行外周血干细胞动员已经广泛应用于临床。

Mobilization of hematopoietic stem and progenitor cells from the bone marrow into the circulation by repetitive , daily stimulation with Granulocyte colony-stimulating factor ( G-CSF ) is widely used for clinical transplantation .