突变谱

M2代诱变效果显著，突变谱宽，有益突变（早熟、矮杆、穗形）频率明显高于γ射线，且较易诱发早抽穗性状变异。

Wider mutational spectrum and higher useful mutation frequencies ( earlier earing , dwarf stem , spike form ) were observed in M2 generation by heavy ions treatment than in that by γ - ray treatment .

离子注入是一种新型的作物诱变技术。离子注入不仅损伤轻，而且突变率高，突变谱广并可定向引变。

Ion implantation as a new mutagen caused high mutation rate and wide mutational spectrum with low damage , and it was also mutated in the direction .

低能重离子引起DNA链断裂和诱发基因突变谱的研究

Study on DNA Strand Breaks and Mutation Spectrum Induced by Low-energy Heavy Ions

~（60）Coγ射线所致HeLaMR细胞hprt基因突变谱研究

Study on the mutation spectrum of HPRT gene in HeLa Mr cell induced by γ ray

丙烯酰胺诱导小鼠淋巴瘤细胞tk基因突变谱的实验研究

Mutational spectra in the tk gene of mouse lymphoma cells induced by acrylamide

本研究丰富了中国人PAH基因突变谱。

This study enriched the mutation spectrum of PAH gene in the Chinese population .

丙烯酰胺诱导人白血病HL-60和NB4细胞hprt基因的分子突变谱

Molecular spectra of acrylamide-induced mutation at hprt locus in human promyelocytic leukemia HL-60 and NB_4 cell lines

新疆南部地区维吾尔族妇女宫颈癌组织中人乳头状瘤病毒16型L1基因突变谱分析

Mutations of human papillomavirus ( HPV ) 16 type L1 genes from cervical carcinoma biopsies in southern Xinjiang Uygur women

应用PCR-DNA测序技术检测SSCP阳性标本中p53基因5-8外显子碱基突变谱和氨基酸顺序改变。

PCR-sequencing was directly used to detect DNA mutations in exon 5 ~ 8 of cases with positive SSCP .

西安市病例p53第五外显子突变谱相对集中（157、159密码子为主），G→T颠换较多见（5／10）；

In Xi , an EC cases the mutation spectrums of exon 5 were relatively concentrated ( mainly codon 157 、 159 ), and the G → T transversion was most prevalent ( 5 / 10 );

目的探讨WTK1细胞tk位点自发和诱发突变体的突变谱和突变热点。

Objective To explore the tk gene mutation spectrum in spontaneous and induced WTK1 mutants .

结论：肺鳞癌、腺癌的Ki-ras和p53基因突变谱较广，肺鳞癌和腺癌的预后均与这两个基因突变有关。

Conclusion : There are wide ki-ras and p53 mutational spectra in lung squamous cancer and lung adenocarcinoma , and there is a relation between prognosis of lung cancer and lung and ki-ras or p53 mutation .

目的：研究肺鳞癌、腺癌与Ki-ras基因外显子1,2及p53基因外显子7,8突变谱并观察肺鳞癌、腺癌预后同Ki-ras和p53基因突变的关系。

Objective : To investigate mutational spectra of Ki-ras gene exons 1,2 and p53 gene exons 7,8 in patients with lung squamous cancer and lung adenocarcinoma and to look into prognosis of patients with Ki-ras or p53 mutation and with no mutation .

目的了解中国人葡萄糖6磷酸酶（G6Pase）基因突变谱和突变热点，并分析糖原累积病Ⅰa型（GSDⅠa）基因型和临床表型的相关性。

Objective To obtain the mutation spectrum of glucose-6-phosphatase ( G6Pase ) gene in Chinese patients with glycogen storage disease type ⅰ a ( GSD ⅰ a ) and to analyze the relationship of its genotype and phenotype .

中国血友病A患者基因突变谱的研究

F ⅷ Gene Mutation Spectrum in Chinese Hemophilia A Patients

结论本研究获得了广州市海珠区人群的地贫发生率和基因突变谱的分布特点，为我区开展地贫人群遗传咨询、产前诊断和预防计划提供了有价值的资料。

Conclusions : Our study obtained the prevalence and spectrum of α - and β - thalassaemia in Guangzhou Haizhu district . Our results could provide valuable genetic data for genetic counseling , prenatal diagnosis and carrying out population prevention program of thalassemia .

重离子束辐照能诱导作物发生遗传性变异，与传统的物理诱变方法相比，具有生理损伤小、突变谱广、突变频率高，并有一定的重复性和方向性的特点。

With the heavy ion irradition is used inducing crop genetic variation , compared to traditional new approaches of physical mutagenesis , having the characteristics of the less physiological damage , wide mutation spectrum , higher mutation frequency , a certain repeatability and directivity .

同时，驱动突变的突变谱在不吸烟和吸烟的肺腺癌中，以及在肺腺癌和肺鳞癌中差异很大，提示不同的致病机理。

The oncogenic mutation spectrum between smokers and non-smokers in lung adenocarcinoma , as well as between adenocarcinoma and squamous carcinoma is diverse .

5例放射事故病人照后5.5年外周血淋巴细胞HPRT基因突变频率和突变谱的测定

Determination of the HPRT gene mutation frequency and mutation spectrum in the peripheral lymphocytes in 5 patients at 5 . 5 years after γ ray over exposure

与线粒体聚合酶γ基因突变相关的表型谱

Phenotypic spectrum associated with mutations of the mitochondrial polymerase γ gene

结果：家族性结肠息肉病是由于基因突变所致，突变谱的不同决定了其临床表现的多样性；

Results : FPC is resulted from gene mutation , and different mutations lead to wide varieties of clinical manifestation .

此外，配子处理损伤小，M2突变率较高，突变谱较广，而且方法较合子处理简便易行。

Besides , gamete treatment resulted in less damage in M1 , high mutagenic rate in M2 , as well as wide mutation spectrum . Moreover , this treatment was easier than zygote treatment .

为了研究丙烯酰胺的遗传毒理作用，采用单细胞克隆培养，双向筛选计数，多重PCR扩增与电泳分析，研究了诱导HL60和NB4两种细胞hprt基因突变率及分子突变谱。

The genotoxicity of acrylamide was investigated by methods of single cell clone culturing , two way screening count , multiplex PCR amplification and electrophoresis technique .

离子注入作为一种诱变源，具有突变率高、突变谱广等特点。

Ion implantation is a mutation resource with some advantages , such as high mutation efficiency , wide mutation spectrum .

离子注入诱变技术是近二十年来发展起来的新型育种技术，以其突变率高、突变谱广等特性在微生物育种中得到广泛应用。

Ion beam implantation mutation is a new technology of breeding strains raised in recent two decades . Due to the higher mutation rate and wider mutational spectrum , it has been widely used in breeding of microbes .

这种突变的频率高、突变谱广、变异幅度大、变异性状稳定快，使育种周期缩短。

The space mutation features high variation frequency and wide variant amplitude and spectrum , traits easy to be stabilized and short breeding period .

结果表明能获得较高的突变率和较广的突变谱。

The results show it can achieve higher rate of mutation and wider mutational spectrum .

结论：新发现的PKU患者的4种基因新突变，丰富了PKU患者PAH基因突变谱。

Conclusion : We found 4 novel mutations which extend the spectrum of Chinese PAH mutations .

在肺癌的不同组织类型中，外显子19的突变形式存在显著差异，肺腺癌的基因突变谱与肺鳞癌、腺鳞癌及小细胞肺癌明显不同。

The profile of mutations varied among the different histological types of lung cancer and the mutation pattern in adenocarcinoma was quite different from lung squamous carcinoma , adeno-squamous carcinoma , and small cell lung cancer .