甲基化酶

抗衰老药物对大鼠脑DNA甲基化酶的影响

Effect of Anti - Aging Drug on DNA Methylase of Brain in Rats

该方法有望成为Dam甲基化酶的抑制、激活因子的高通量筛选方法。

It has the potential for the application of screening the inhibitor or activator of Dam methylase .

人参对小鼠肝DNA甲基化酶活力的影响

Affect of Ginseng to DNA Methylating Enzyme Vitality in Mouse Liver

DNA甲基化酶抑制剂对体细胞染色体的影响

Effect of the DNA Methyl-transferase Inhibitor on Chromosome of Donor Cells

人胃癌组织DNA甲基化酶、去甲基化酶与肿瘤相关基因的表达

The expression of DNA methyltransferase , demethylase and tumor-associated genes in human gastric cancer

重组DNA甲基化酶1表达质粒对结肠癌细胞相关基因表达的影响

Effect of recombinant DNA methylferase 1 plasmid on the expression of tumor-associated gene in human colon cancer cell line

发夹型荧光分子探针用于DNA甲基化酶的活性分析及其在药物筛选中的应用

An Assay for the Activity of DNA Methylase Based on a Hairpin Fluorescence Molecular Probe and Its Application in Drug Selection

丝裂原激活蛋白激酶阻断剂与DNA甲基化酶抑制剂对人结肠癌细胞的协同影响

The co-effect of extracellular-signal regulated kinase mitogen-activated protein kinase signaling pathway inhibitor and DNA methyltransferase inhibitor on human colon cancer cells

DNA重新甲基化酶3b在成年及新生小鼠部分组织中的选择性剪接表达

Alternative Splicing of de novo Methyltransferase Gene 3b in Adult and Newborn Mice

糖尿病肾病大鼠肝DNA甲基化酶活性及基因组DNA对DNase敏感性的分析

Activity of DNA methylase and DNase sensitivity assay of genome DNA of liver from rat of diabetic nephropathy

新疆地区鲍氏不动杆菌氨基糖苷类修饰酶与16SRRNA甲基化酶基因研究

Aminoglycoside-modifying Enzyme and 16S rRNA Methylase Gene Expressions in Acinetobacter baumannii

宁波地区鲍曼不动杆菌16SRRNA甲基化酶基因研究

Study on 16S rRNA methylase genes among acinetobacter baumannii in Ningbo

这些基因主要包括基础代谢有关基因，转运子基因，转录调控有关的基因，DNA复制及修复，细菌自溶酶以及甲基化酶基因等。

The functions of these differentially expressed genes were involved in basic metabolism , gene transcription regulation , transporter , DNA repair and replication , autolysin and methylation .

革兰阴性菌中16SRRNA甲基化酶基因的检测

Detection of 16S rRNA Methylases Gene in Gram-negative Bacteria

ESBLs在产16SRRNA甲基化酶鸡大肠杆菌中的流行

Prevalence of ESBLs among 16S rRNA Methylase-producing Escherichia Coli Strains Isolated from Diseased Chickens

噬菌体T4脱氧胞苷酸羟甲基化酶基因与免疫基因在大肠杆菌极大细胞中的表达

Expression of Bacteriophage T4 Deoxycytidylate Hydroxymethylase Gene and Immunity Gene in E. coli Maxicells

去甲基化酶（MBD2）是DNA甲基化的重要组成部分。

Demethylase ( MBD2 ) is an important part of the DNA methylation .

多药耐药铜绿假单胞菌氨基糖苷类修饰酶和16SRRNA甲基化酶基因分析

Analysis on gene types of aminoglycoside modifying enzyme and 16S rRNA methylases in multidrug-resistant Pseudomonas aeruginosa

烧伤病房鲍氏不动杆菌质粒介导的16SRRNA甲基化酶基因及耐药性传递研究

Study of Plasmid-mediated 16S rRNA Methylase Genes and Its Drug-resistant Transferability in Acinetobacter Baumannii Isolates from Burn Ward

氨基糖苷类药物高水平耐药16SRRNA甲基化酶基因在动物源大肠杆菌中的检测

Detection of 16S rRNA Methylase Genes Which Mediated High Level Resistance to Aminoglycosides among Escherichia coli Strains Isolated from Animals

EcoRⅡ限制性内切酶和甲基化酶基因克隆、表达和缺失突变分析

Expression and Deletion Analysis of EcoR ⅱ Endonuclease and Methylase Gene

结果显示：糖尿病肾病大鼠肝DNA甲基化酶活性明显低于正常鼠肝，其基因组DNA对DNase敏感性比正常大鼠肝增强；

The results demonstrate that DNA methylase activity of rat liver of Diabetic Nephropathy is obviously lower than the control , and its genome DNA possesses higher sensitivity to Dnase I than that of the control .

本文用极大细胞的方法研究噬菌体T4脱氧胞苷酸羟甲基化酶基因（基因42）与免疫基因（基因imm）的表达。

This paper deals with the expression of bacteriophage T4 deoxycytidylate hydroxy-methylase gene and immunity gene in E. colt by means of " maxicells " .

初步提示，垂直克隆传播，而不是水平传播在其16SRRNA甲基化酶耐药基因扩散中发挥重要作用。

This may suggest the vertical transfer but not the horizontal transfer has played an important role in the dissemination of the 16S rRNA methylase gene rmtB in proteus mirabilis .

质粒介导的16SRRNA甲基化酶是近年来新发现的一种耐药决定因子，可导致革兰氏阴性细菌对4,6-二取代基-脱氧链霉胺类氨基糖苷类药物（如庆大霉素、阿米卡星等）高水平耐药。

Plasmid-encoded 16S rRNA methylase , which confer high-level resistance to 4 , 6-disubstituted deoxystreptamine aminoglycosides ( such as amikacin and gentamicin ) in many Gram-negative pathogens , is a novel discovered resistant determinant .

结果：（1）光镜观察到5-aza-C和SPB单用及联用均具有生长抑制、诱导DNA甲基化酶抑制剂和组蛋白脱乙酞化酶抑制剂的抗肿瘤研究分化及凋亡作用；

RESULTS ( 1 ) 5-aza-C used alone or SPB used alone or both used in combination all have antiproliferation , differentiation and apoptosis effect when showed by ordinary microscopy and flow cytometry .

3个16SRRNA甲基化酶基因中，armA基因的检出率最高，达98%（51/52），rmtB，rmtC基因未检出。

The detection rate of armA was the highest among the 3 16s rRNA methylase genes , up to 98 % ( 51 / 52 ) . rmtB and rmtC were not detected out .

用蔗糖锑度密度离心初步纯化的酶与标准蛋白质作SDS聚丙烯酰胺凝胶电泳，得出脱氧苷酸羟甲基化酶的分子量为26000道尔顿。

This indicated that the enzyme involved was permeable through the cell wall . The enzyme was purified through sucrose density gradient centrifugation , and its molecular weight was proved to be 26.000 ( known 25,000 ) daltons by SDS polyacrylamide gel electrophoresis with known standard proteins as references .

同时对4种常见的氨基糖苷修饰酶基因及3种16SRRNA甲基化酶基因armA，rmtB及rmtC进行扩增，对扩增结果为阳性的基因利用RT-PCR的方法分析阿米卡星诱导前后耐药基因表达量。

Meanwhile , the four frequent types of genes coding aminoglycoside-modifying enzyme and three kinds of 16S rRNA methylase genes-armA , rmtB and rmtC were amplified by PCR . And the expressions of positive gene in drug-induced strains and non-induced strains were respectively measured by PT-PCR .

甾醇14α-去甲基化酶（也称P45014-DM，CYP51）是唯一的广泛存在于细菌、真菌、植物和动物中的细胞色素P450家族成员。它被视为最古老的细胞色素P450家族成员。

Sterol 14 α - demethylase ( other names : P450 14DM ; CYP51 ) is the only member of the cytochrome P450 superfamily present in animals , plants , fungi , bacteria and considered to be the most ancient member of the superfamily .