氨基酸代谢紊乱

结论：3-甲基胆蒽诱发小鼠胃癌模型中丝氨酸、脯氨酸升高可作为胃癌氨基酸代谢紊乱的一种反映，而5-氟脲嘧啶与黄芪联合应用可减少胃癌组织中谷氨酸含量，抑制肿瘤生长。

Conclusion : The increasing concentration of free serine and proline in mice gastric cancer induced by 3-MC can reflect the metabolic disturbance of amino acid . The decreasing concertration of free glutamic acid treated with combining of 5-Fu and astragalus membranaceus may play a role of inhibition tumor growth .

而照后1d仅见γ氨基丁酸和甘氨酸含量仍较高（P<0.01）。结论S波段高功率微波辐射可引起大鼠大脑皮层神经元尼氏体、突触结构和髓鞘等损伤及氨基酸类神经递质代谢紊乱。

Conclusion S band HPM radiation can induce the injure of Nissel body , synapse and myelin sheath of neuron , and the disorder of amino acids in cerebral cortex .

缺乏这两种氨基酸会造成人体代谢紊乱，甚至引发某些生理机能性疾病。

Absence of amino acids will bring about a disturbance of body metabolism even some disease relating to physiological function .

而肝脏是机体物质代谢的枢纽，承担了大部分的合成、分解、转化和排泄等代谢过程，一旦受损，将导致糖类、脂类、氨基酸等物质的代谢紊乱。

However the liver plays a central role in the metabolism of carbohydrates , fatty acids , amino acids and so on . It undertakes most of the synthesis , decomposition , transformation , excretion and other metabolic processes . Once damaged , it would lead to substance metabolism disorder .

目的建立可靠的串联质谱技术检测干血滤纸片中氨基酸方法，以便用于氨基酸代谢紊乱疾病的筛查和诊断。

Objective To establish a method for amino acid analysis in dry blood filter paper by tandem mass spectrometry for newborn screening and diagnosis of amino acid disorders in children .