螺内酯

原发性高血压病人醛固酮逃逸现象及螺内酯的干预研究

Phenomenon The Aldosterone Escape in Essential Hypertension and the Interference with Spirolactone

随机螺内酯评估研究表明在心力衰竭治疗中加用醛甾酮拮抗药可使总死亡率降低30%。

Randomized aldactone evaluation study ( RALES ) showed that adding aldosterone antagonist in the treatment of heart failure may decrease 30 % mortality of all causes .

复方螺内酯霜的HPLC测定

Determination of Spironolactone in Compound Spironolactone Cream by RP-HPLC

结论福辛普利与螺内酯可改善AMI并发左心功能不全病人的心功能。

ConclusionFosinopril Sodium and antisterone could improve the cardiac function in patients with AMI and left cardiac insufficiency .

所有病人都得到最佳的药物治疗包括p他洛克阻滞剂，血管紧张素转换酶抑制剂，血管紧张素受体拮抗剂，螺内酯，利尿剂等。

At the time of CRT device implantation , all patients were receiving optimal medications , including beta-blockers , angiotensin-converting enzyme inhibitors or angiotensin receptor blockers , spironolactone , and loop diuretics .

目的观察福辛普利与螺内酯对急性心肌梗死（AMI）并发左心功能不全病人心功能的影响。

ObjectiveTo observe the effect of Fosinopril Sodium and antisterone on acute myocardial infarction ( AMI ) with left cardiac insufficiency .

螺内酯、氯沙坦对AMI大鼠血浆胶原代谢产物及心肌组织心钠素、醛固酮的影响

Impact of spironolactone , losartan on the plasma collagen metabolism and cardiac atrial natriuretic peptide , aldosterone levels in AMI rats

目的：观察醛固酮拮抗剂&螺内酯对原发性高血压（EH）患者心肌纤维化的影响。

Objective : To explore the effects of aldosterone antagonism spironolactone on cardiac fibrosis in patients with essential hypertension .

背景：接受标准治疗的重度心力衰竭（HF）患者加用螺内酯可以明显改善其临床预后。

Background : Add-on spironolactone therapy substantially improves clinical outcomes among patients with severe heart failure ( HF ) on standard therapy .

观察二甲双胍和螺内酯对多囊卵巢综合征患者ghrelin的影响

Studies on effects of Metformin and Spironolactone on plasma ghrelin in polycystic ovary syndrome

但是，对轻中度收缩性HF患者，螺内酯联合血管紧张素II受体拮抗剂对左室（LV）逆重构的价值目前还不清楚。

However , the value of combining spironolactone with an angiotensin II receptor blocker on LV reverse remodeling in mild-to-moderate systolic HF is unclear .

螺内酯对高糖诱导的大鼠肾小球系膜细胞PAI-1表达的抑制作用

Inhibitory effects of spironolactone on expression of plasminogen activator inhibitor-1 induced by high glucose in rat glomerular mesangial cells

方法采用双盲法将高胰岛素型高血压病人162例随机分组，分别服用小剂量螺内酯（A组，83例）及安慰剂（B组，79例），疗程8周，测量并比较以上数据变化。

Methods We divide 162 patients into two groups randomly . 83 patients take small dosage of spironolactone , and the others take placebo . After 8 weeks of treatment , we measure and compare the data in them .

目的探讨螺内酯对高血压动脉重塑的作用以及对血浆肾上腺髓质素（adrenomedullin，ADM）的影响。

Objective To investigate the effects of spironolactone on aorta remodeling and the levels of plasma adrenomedullin in hypertensive rats .

结论：坎地沙坦联合螺内酯治疗对轻中度慢性收缩性心力衰竭患者的LV逆重构有明显益处。

Conclusions : The addition of spironolactone to candesartan has significant beneficial effects on LV reverse remodeling in patients with mild-to-moderate chronic systolic HF .

结论①心力衰竭患者ACEI治疗后，不管是否加用螺内酯均可观察到醛固酮逃逸现象。

Conclusion ① The aldosterone escape appears in congestive heart failure patients with ACEI treatment irrespective of spironolactone use .

VG染色、网状纤维染色可见螺内酯预防组肝纤维化程度明显降低（P<0.01）。

The grade of hepatic fibrosis was significantly decreased in spironolactone prevention group ( P < 0.01 ) .

目的：观察螺内酯（Spironolactone）对体外培养的人毛囊生长的影响。

Objective : To observe the effect of spironolactone on the growth of human hair follicle in vitro .

目的研究醛固酮抑制剂螺内酯对急性心肌梗死（AMI）患者心肌胶原纤维合成指标和左室收缩、舒张功能指标的影响。

Objectives To evaluate the effects of spironolactone on the postinfarction collagen synthesis and the left ventricular systolic and diastolic function in patients with acute myocardial infarction ( AMI ) .

目的探讨螺内酯、氯沙坦对急性心肌梗死（AMI）大鼠血浆胶原代谢产物及心房利纳系统的影响。

To investigate the effects of spironolactone , losartan on the plasma collagen metabolism and cardiac atrial natriuretic peptide , aldosterone levels in acute myocardial infarction ( AMI ) rats .

螺内酯组：造模同高血压组，螺内酯20mg/（kg·d）灌胃，连续14d。

Rats in the spironolactone group received modeling the same as hypertensive group and intragastric perfusion of 20mg / kg spironolactone per day for 14 continuous days .

方法：12例患者治疗前先使用地高辛和排钾利尿药，入选后加用螺内酯和ACEI。

Methods : 12 patients who had been administrated with digoxin and urinative before the trial were added with spironolactone and ACEI .

目的：探讨醛固酮受体拮抗剂螺内酯对肝纤维化大鼠肝星状细胞活化及胶原合成的影响.方法：用CCl4花生油、高脂和低蛋白复合因素制造大鼠肝纤维化模型。

AIM : To investigate the effect of aldosterone receptor antagonist on the synthesis of collagen and the activation of hepatic stellate cells in rats .

两组均给予优思弗治疗，肝功能转氨酶较高者加用五酯胶囊，HBVdna阳性达到抗病毒治疗者行常规抗病毒治疗，有腹水者适当给予呋塞米及螺内酯行利水处理。

Two groups were given UDCA therapy , the higher liver transaminase plus five capsules , HBV DNA positive to anti-viral therapy with conventional anti-viral treatment , with ascites is appropriate , given the line of furosemide and spironolactone treatment benefit .

螺内酯对截肢创伤致大鼠心肌线粒体损伤的拮抗FK506对截肢创伤应激后心肌线粒体损伤的保护作用

Mechanism of myocardial mitochondria injury and protection of spironolactone after traumatic amputation Protective effect of FK506 on the myocardial mitochondrial damage following traumatic stress of amputation in rats

结论重度心衰患者在常规应用洛汀新的基础上加用螺内酯可通过进一步降低TNF-α、Ald、AngⅡ水平而明显改善心室重塑及EF值，且在小范围内有一定剂量依赖性。

Conclusion The treatment of lotensin with different doses of spironolactone can further reverse myocardial remodeling and improve EF via decreasing TNF - α, Ang ⅱ and Ald in CHF patients .

螺内酯组NF-κbmRNA表达无明显变化。结论①在改善心力衰竭大鼠心功能和心室胶原重构方面，缬沙坦和螺内酯联合使用的作用大于二者单独使用。

Spironolactone group of NF - κ B mRNA expression was not changed significantly . Conclusions ① heart failure in improving cardiac function and ventricular remodeling in mice , the effect of valsartan and spironolactone on the role of joint use is greater than the two alone .

结论联合应用氢氯噻嗪、依那普利、美托洛尔、螺内酯治疗小儿DCM能明显延缓或防止心肌重塑进展，改善心脏功能，提高生存质量。

Conclusion Therapeutic alliance with dihydrochlorothiazide , enalapril , metoprolol and spironolactone may help to postpone or prevent myocardium remodeling , and to recover heart function and raise existing quality in children with DCM .

与腺嘌呤模型组比较，螺内酯组大鼠肾小管间质CTGF、TIMP-1表达明显减弱，MMP-9/TIMP-1比值上升。

Compared with the adenine model group , the expression of the CTGF , TIMP-1 greatly declined in the renal tubulointerstitium in the spironolactone group , and the rate of MMP-9 / TIMP-1 rises considerably .

贝那普利组、螺内酯组及联合治疗组血清VCAM-1及胆固醇、甘油三酯浓度均降低，蛋白尿减少，血清白蛋白浓度升高；

In C , D , and E group , the levels of serum VCAM-1 x cholesterol and triglycerides all decreased , the proteinuria also decreased , while the levels of serum albumin increased .