克拉维酸

目的提高棒状链霉菌的克拉维酸生产能力，去除副产物头霉素C。

Objective To improve the production of clavulanic acid and to genetically delete cephamycin C in the fermentation of Streptomyces clavuligerus .

用头孢噻肟，头孢噻肟/克拉维酸、头孢他啶，头孢他啶/克拉维酸这两对纸片同时进行筛检超广谱β-内酰胺酶，可有效降低ESBLs漏检率。

Using both CTX , CTX / Clavulanic acid and CAZ , CAZ / Clavulanic acid simultaneously can reduce the missing rate of ESBLs .

阿莫西林克拉维酸钾泡腾片的HPLC测定

Determination of Amoxicillin Potassium Clavulanate Effervescent Tablets by HPLC

pH值对替卡西林钠-克拉维酸钾与药物配伍产生沉淀的影响

Effect of pH value to the precipitate in the compatibility of Ticarcillin / Clavulanate acid with other drugs

目的：建立阿莫西林-克拉维酸血药浓度的HPLC法。

AIM : To establish a HPLC method for the determination of amoxycillin-clavulanic acid in human plasma .

RP-HPLC法同时测定人血清中阿莫西林、克拉维酸钾浓度

Determination of Amoxycillin Clavulanate Potassium in Human Serum by RP-HPLC

柱切换HPLC法同时测定人血浆中阿莫西林和克拉维酸浓度。

A column switching HPLC method has been developed for the simultaneous determination of amoxicillin and clavulanate in human plasma .

方法采用HPLC，比较阿莫西林和克拉维酸钾单独存在及复方后杂质谱的变化。

METHODS The impurity profiling changes of amoxicillin plus potassium clavulanate were compared with both amoxicillin and potassium clavulanate alone by HPLC .

目的建立两种HPLC线性梯度洗脱测定阿莫西林/克拉维酸钾有关物质的方法，并对其进行比较。

Objective Two HPLC methods with linear gradient elution for determination of the related substances of amoxicillin-potassium clavulanate were established and compared .

用HPLC法同时测定血浆中克拉维酸和阿莫西林的浓度，计算克拉维酸和阿莫西林的药代动力学参数，计算分散片的相对生物利用度。

Bioequivalence of amoxicillin and clavulanic acid tablets in healthy volunteers The plasma concentration of clavulanic acid and amoxicillin simultaneous were determined with HPLC .

本文考察了溶剂种类、晶种、搅拌速率、流加速率、溶液pH值、结晶温度等工艺条件对克拉维酸钾反应结晶过程的影响。

Factors influencing the potassium clavulanate crystallization , such as solvents , crystal seeds , stirring rate , reactant adding rate , pH and temperature , were investigated .

结果替卡西林钠-克拉维酸钾与pH较低的左氧氟沙星、阿米卡星配伍产生沉淀，加碱性试液pH升高后，溶液变澄清。

Results Precipitate happened in the compatibility of Ticarcillin / Clavulanate acid with low pH drugs such as Levofloxacin and Amikacin . The precipitate was dissolved by adding sodium hydroxide solution .

结果：阿莫西林钠克拉维酸钾组的C/E值最小，头孢哌酮钠舒巴坦钠组的ΔC/ΔE值最低。

Results : The group of amoxicillin / clavulanic was the lowest C / E group . The group of cefoperazone / sulbactam sodium was the lowest △ C / △ E group .

结论以头孢噻肟，头孢噻肟/克拉维酸这对纸片可达到有效进行CTX-M酶的表型检测的目的；

Conclusions The phenotypic confirmatory tests for CTX-M enzymes can be detected only by CTX and CTX / Clavulanic acid effectively .

目的：测定头孢哌酮和哌拉西林与克拉维酸、舒巴坦、三唑巴坦3种β内酰胺酶抑制剂的复合制剂的最小抑菌浓度（MIC）、杀菌曲线。

Objective : To measure the minimal inhibitory concentration ( MIC ), time-kill curve of the composite preparation of β - lactams and β - lactamase inhibitors against β - lactamase-producing Gram-negative bacteria in vitro .

糖的代谢途径对克拉维酸的生物合成也有显著的影响，当添加低浓度（0.1。g／100ml）的碘乙酸改变糖的代谢途径时，明显促进了克拉维酸的生物合成。

When low concentration ( 0 . lmg / 100ml ) iodoacetic acid was added to fermentation media in the beginning of fermentation to alter the catabolism pathway of saccharide , the biosynthesis of clavulanic acid was promoted obviously .

阿莫西林/克拉维酸钾的流动相为磷酸盐缓冲液-甲醇（95∶5），检测波长为220nm。

Amoxicillin / clavulanate potassium used : Mobile phase was phosphate solution-methanol ( 95 ∶ 5 ), detected at 220 nm .

从杀菌曲线分析，绝大多数复合制剂为时间依赖性，而头孢哌酮/克拉维酸（1/1）对产ESBL的肺炎克雷伯菌有浓度依赖趋势。

According to the time-kill curves , most of composite preparations killed the bacteria in a time-dependent manner , but the composite preparations of cefoperazone / clavulanicacid ( 1 / 1 ) killed K.

在ICU，鲍曼不动杆菌对亚胺培南暂无耐药性，其次对头孢吡肟、替卡西林/克拉维酸、哌拉西林/三唑巴坦和阿米卡星的耐药率分别为18%、29%、35%和38%。

The Acinetobacter baumannii have no drug resistance to imipenem in ICU at this time , The drug resistant rate of A baumannii to Cefepime , ticarcillin / clav , piperacillin / tazobactan , and amikacin is 18 % , 29 % , 35 % , and 38 % respectively .

目的探讨氟氯西林、克拉维酸与超广谱头孢菌素协同法（双抑制剂扩散协同法，DIDST）检测AmpCβ内酰胺酶（AmpCBLA）和超广谱β内酰胺酶（ESBLs）的应用价值。

Objectives To consider the reliability of using flucloxacillin ( FCC ) and clavulanic with extended spectrum cephalosporin synergy method ( double inhibitors diffuse synergy test , DIDST ) to detect AmpC β lactamases ( AmpC BLA ) and extended spectrum β lactamases ( ESBLs ) .

结果：头孢哌酮舒巴坦钠金额和DDDs均排第1,3年的金额和DDDs均占此类药物49%以上，其次是阿莫西林克拉维酸钾，DDDs占22%以上，两者之和占77%以上。

RESULTS : Cefoperazone sulbactam sodium ranked first in amount of money and DDDs , total amount of money and DDDs of 3 years took up over 49 % of this kind of drug . Amoxicillin potassium clavulanate ranked second , its DDDs took up over 22 % .

关联度分析法优化克拉维酸发酵培养基

Optimization of Fermentation Medium of Clavulanic Acid by Analyzing Relational Grades

注射用阿莫西林钠克拉维酸钾细菌内毒素检查

Bacterial Endotoxin Test of Amoxicillin Sodium and Clavulanate Potassium for Injection

克拉维酸钾及其复方制剂的有关物质测定

Determination of Related Substances of Clavulanate Potassium and Its Compound Preparation

克拉维酸锂的制备及其有关物质研究

Studies on the Preparation and the Relative Substance of Lithium Clavulanate

克拉维酸/阿莫西林分散片与普通片的人体相对生物利用度研究

Relative bioavailability of clavulanic acid / amoxicillin dispersive tablets in healthy volunteers

克拉维酸发酵液中碳源&甘油含量的比色法测定

Determination of Glycerol Content in Clavulanic Acid Broth by Spectrophotometry

克拉维酸钾阿莫西林干混悬剂稳定性影响因素的考察

Factors influencing the stability of the suspension containing potassium clavulanate and amoxicillin

阿莫西林-克拉维酸注射剂及其在猪体内的药物动力学研究

Study on Amoxycillin-Clavulanic Acid Suspension and its Pharmacokinetics in Swine

国产和进口阿莫西林-克拉维酸治疗小儿肺炎的疗效比较

Domestic vs imported amoxicillin / clavulanic acid in treating pneumonia of children