交叉试验

方法采用随机两阶段交叉试验研究设计。

Methods A randomized two-stage cross-over trial covering 18 weeks was used in the study .

前言：目的：探讨广义估计方程在交叉试验等级资料中的应用，为临床试验交叉设计资料的正确分析提供方法学参考。

Objective : To explore the application of generalized estimating equation in ordered categorical data of cross-over trial analysis and provide methodology reference .

2种氟康唑胶囊的主要药动学参数经交叉试验方差分析示无统计学差异（P均>0.05）。

Main pharmacokinetic parameters between test capsule and reference one showed no significant difference based on analysis of variance ( P > 0.05 ) .

RT-PCR与兔体交叉试验检测猪瘟病毒感染的相关性研究

Study on relationship between RT-PCR and rabbit-cross test for detection of classical swine fever virus

试验选取16头生产性能稳定的荷斯坦奶牛，采用交叉试验设计，设计两个处理组（A组和B组），试验分为两个时期，两组在两期中互为对照。

Adopting the cross design , 16 Holstein-Friesian cows of stable production performance were divided into group A and group B. The experiment was divided into two periods .

本文用十字交叉试验设计法考察pH值、光照强度和光照时间对氧氟沙星葡萄糖注射液稳定性的影响。

Effects of different pH , illumination time , illumination intensity on the stability Of ofloxacin were observed by means of cross curve experiment design .

对猪瘟RTPCR诊断方法与兔体交叉试验诊断方法的相关性进行了研究。

Relationship between RT-PCR and rabbit-cross test for detection of classical swine fever virus ( CSFV ) was studied in this experiment .

目的应用流式细胞仪（FCM）进行血小板相关抗体检测和血小板交叉试验。

Objective Use of flow cytometry ( FCM ) in platelet - associated antibody detection and platelet cross-matching .

方法30例男性健康成人随机分为两组（HF组和对照组）进行交叉试验；

Methods Thirty male volunteers were randomly divided into two groups , high fat and low carbohydrate group ( HF group ) and control group .

交叉试验与重复试验结果显示DIGFA具有较好的特异性及稳定性。

Cross test and repeated test showed that DIGFA had better specificity and steadiness .

方法：21名健康男性受试者参加了单剂量（600μg）三周期交叉试验并用放免分析法测定给药后不同时间点血清药物浓度。

METHODS : 2 1 healthy male volunteers received a single oral doses of 600 μ g of levothyroxine sodium in three times cross - over clinical trial and their serum drug concentration were determined by Radioimmunoassay ( RIA ) .

对照组15例PTR病人随机进行血小板交叉试验。

The other 15 patients with PTR in controlled group were matched the platelet donors randomly by the platelet cross matching test .

通过对检测抗原的交叉试验及阻断试验均证明，检测抗原只与抗GPMV抗体发生特异性结合。

It is testified that the coating antigen only react with GPMV antibody by crossing assay and blockage assay .

实验组15例PTR病人先进行HLA分型，到血小板库中寻找合适供者，再进行血小板交叉试验。

15 patients with PTR in experimental group were required first to select the HLA matching donors from the platelet donor bank and then were carried out the platelet cross matching test .

对4头山羊采用交叉试验，结果证实，在颌面部用波导CO2激光进行穴位麻醉下，机体血清总蛋白、球蛋白、γ球蛋白将显著增高，且其变化有一定规律性。

The experiment using crossover method was carried out to measure the serum proteins in 4 goats under wave-guide CO2 laser anesthesia . The results showed that the level of serum total protein , global protein and y global protein were elevated significantly with regular patterns .

方法：采用双周期双交叉试验设计方法，6只Beagle犬随机单剂量施用格列美脲舌下喷雾剂（舌下给药）或灌胃片剂，用高效液相色谱法测定给药后的血浆中格列美脲浓度。

Methods : A randomized two-way cross-over design was used . Plasma concentration of glimepiride was determined by RP-HPLC method after Beagle dogs were administrated with a single dose of 2 mg glimepiride sublingual spray or tablets .

试验研究了复火温度（95、110、125℃）和复火时间（1、2、3h）两因素三水平交叉试验对杜仲红茶精制加工过程中品质成分变化的影响。

The effects of different temperature ( 95 , 110 , and 125 ℃) and duration ( 1 , 2 , and 3 hours ) of second drying on the quality and composition of Eucommia black tea during refining process were studied .

本研究采用两阶段交叉试验方法，将18例VD病人随机分为A、B两组、每组各9例，以安慰剂对照、双盲给药，自身前后交叉试验。

The cross-over experiment method was used in our study . 18 cases of VD were divided randomly into 2 groups ( group A and group B ) and there were 9 patients in each group . Placebo-treated and double-blind methods were used , and the patients were cross-over investigated .

方法选择健康志愿者20例，用随机双交叉试验方法，单剂量口服替硝唑片的试验制剂和参比制剂，剂量分别为1g，洗净期为2周；

Methods A single oral doses ( 1g ) of tested and reference preparations of Tinidazole were given to 20 healthy volunteers respectively in a randomised crossover study . The cleaning stage was 2 weeks .

方法将20名健康志愿者分两组进行单剂量双交叉试验，剂量均为500mg，两次试验间隔时间为7d。

METHODS : 20 healthy volunteers were classified into two groups for single dose and two-crossing test , with the dose of 500 mg , 10 volunteers each group and seven days interval between two tests .

通过计算机软件设计了猪瘟病毒E2基因保守区的1对引物，建立了猪瘟病毒RTPCR检测方法，同时应用兔体交叉试验进行对比，对7份临床送检病例进行了检测。

One set of specific primers were designed according to the conserved sequence of E2 gene of CSFV in GenBank and a standard RT-PCR was founded to detect the infection of CSFV . Compared with rabbit-cross test , 7 samples from pigs suspected infection with CSFV were detected with RT-PCR .

方法：健康志愿者20名，用随机双交叉试验方法，单剂量及多剂量po试验及对照制剂162.5和150mg，剂间间隔为2周。

METHODS : A single oral dose ( 162.5 mg of test , 150 mg of reference ) and multiple oral dose s ( 162.5 mg of test , 150 mg of reference for six days ) were given to 20 healthy volunteers in a randomised crossover study .

结果实验组15例病人都可在血小板库中找到HLA-I类位点3个以上抗原相合的供者，血小板交叉试验的阴性率为45.7%。

Results All 15 patients of experimental group could find more than 3 alleles compatible donors on HLA class I from the donor bank and the platelet cross matching compatible rate was 45.7 % . The random cross matching rate of the controlled group was 9.3 % .

流式细胞仪法用于血小板相关抗体检测和血小板交叉试验

Detection of platelet-associated antibody and platelet crossmatching by flow cytometry

设计：这是一项随机对照的交叉试验。

Design : This was a randomized , controlled , crossover trial .

交叉试验的等效性检验是基于交叉试验方差分析中的误差均方计算的。

Equivalence test of cross-over design is based on mean square of ANOVA .

对照组血小板交叉试验的阴性率为9.3%。

There was different significantly on the rate of platelet cross matching test .

交叉试验设计资料的等效性检验

Equivalence Test for Cross - over Clinical Trial

研究设计与方法本研究为一项双盲、随机、交叉试验。

RESEARCH DESIGN AND METHODS This was a double-blind , randomized , crossover trial .

这与交叉试验相似。

These are similar to cross-over trials .