亚甲基四氢叶酸还原酶

5,10-亚甲基四氢叶酸还原酶多态性和神经管畸形的病例对照研究

A case-control study of MTHFR polymorphism and neural tube defects

重庆地区人群亚甲基四氢叶酸还原酶基因多态性与结直肠癌易感性关系研究

MTHFR polymorphisms and colorectal cancer susceptibility in Chongqing people

人类5,10-亚甲基四氢叶酸还原酶N端部分的克隆和表达

Cloning and expression of N terminal human 5 , 10-methylenetetrahydrofolate reductase code gene

PCR-RFLP法检测N~5，N~（10）-亚甲基四氢叶酸还原酶基因多态性及其临床意义

Detection of N ~ 5 , N ~ 10-methylenetetrahydrofolate reductase gene polymorphism by using PCR-RFLP and its clinical significance

目的：探讨上海社区人群亚甲基四氢叶酸还原酶（methylenetetrahydrofolatereductase，MTHFR）基因多态性与原发性高血压的关系。

Objective : To explore the relationship between methylenetetrahydrofolate reductase ( MTHFR ) polymorphism and risk of essential hypertension among Shanghai community based population .

目的探讨亚甲基四氢叶酸还原酶（methylenetetrahydrofolatereductase，MTHFR）基因多态性与血液透析（hemodialysis，HD）患者心、脑血管疾病的关系。

Objective To investigate the relationship between methylenetetrahydrofolate reductase ( MTHFR ) gene polymorphism and cardiovascular and cerebrovascular diseases ( CVD ) in hemodialysis ( HD ) patients .

目的：探讨同型半胱氨酸（Hcy）代谢相关酶N5,10亚甲基四氢叶酸还原酶（MTHFR）及胱硫醚β合酶（CBS）基因突变对脑梗死的致病作用。

Aim : To study the effect of gene mutations of methylenetetrahydrofolate reductase ( MTHFR ) and cystathionine β - synthase ( CBS ) in cerebral infarction .

目的探讨北方乡村妇女亚甲基四氢叶酸还原酶（MTHFR）基因多态性与神经管畸形的关系。

Objective To explore relationship between methylenetetra hydrofolate reductase ( MTHFR ) polymorphism and neural tube defects ( NTDs ) of women in the northern countryside .

目的探讨叶酸、维生素B12、N5，N10-亚甲基四氢叶酸还原酶（MTHFR）基因及血浆同型半胱氢酸（Hcy）水平与Alzheimer病（AD）的关系。

Objective : To study the relationship between plasma folate , vitamin B12 , plasma homocysteine ( Hcy ) levels and the polymorphisms of MTHFR gene in Alzheimer ′ s disease ( AD ) .

结论：①同型半胱氨酸代谢关键酶基因亚甲基四氢叶酸还原酶C677T存在多态性，无民族差异。

CONCLUSION : ① There is polymorphism in Hcy metabolic key enzyme gene MTHFR C677T , and no difference is found between ethnic groups .

目的探讨不同性别原发性高血压患者中血清叶酸水平与甘油三酯水平及亚甲基四氢叶酸还原酶（MTHFR）C677T多态性位点的相关性。

Objective To explore the association of the serum folic acid level with triglycerides level and C677T polymorphisms in methylenetetrahydrofolate reductase ( MTHFR ) in the primary hypertensive patients .

目的研究同型半胱氨酸代谢关键酶亚甲基四氢叶酸还原酶（methylenetetrahydrofolatereductase，MTHFR）基因C677T多态性与糖尿病合并冠心病发病的关系，探讨MTHFR是否为糖尿病合并冠心病的易感基因。

Objective To explore the significance of the gene polymorphisms of methylenetetrahydrofolate reductase ( MTHFR ) C677T in type 2 diabetes mellitus ( DM ) with coronary heart disease ( CHD ) .

目的观察叶酸代谢的关键酶亚甲基四氢叶酸还原酶（MTHFR）基因C677T、A1298C多态与乳腺癌患者对化疗敏感性的关系。

Objective : Methylene tetrahydrofolate reductase ( MTHFR ) is a key enzyme in the metabolism of folic acid and plays an important role in the methylation of DNA .

目的：探讨血清叶酸代谢关键酶亚甲基四氢叶酸还原酶（MTHFR）与胸腺嘧啶合成酶（TS）基因多态性与食管及贲门癌易感性的关系。

Aim : To evaluate the relationship between the polymorphisms of methylenetetrahydrofolate reductase ( MTHFR ) and thymidylate synthase ( TS ) gene and the high susceptibility risk of esophageal squamous cell cancer ( SCC ) and gastric cardia adenocarcinoma ( GCA ) .

结论：亚甲基四氢叶酸还原酶基因突变表型（C667T）是冠心病发病的独立危险因素。

CONCLUSION : The methylenetetrahydrofolate reductase gene mutation phenotype ( C667T ) is an independent risk factor of coronary heart disease .

背景：叶酸缺乏与胃癌发生有关，亚甲基四氢叶酸还原酶（MTHFR）是叶酸代谢途径的关键酶之一，叶酸受体α（FRα）可介导细胞外叶酸进入细胞内。

Background : Folate deficiency is thought to be associated with gastric carcinogenesis . Methylenetetrahydrofolate reductase ( MTHFR ) plays a central role in folate metabolism , and folate receptor alpha ( FR α) can mediate extracellular folate into the cells .

目的为探讨国内血液透析病人血浆总同型半胱氨酸（tHCY）水平及其影响因素，以及与N2，N10-亚甲基四氢叶酸还原酶（MTHFR）基因的关系。

Objective In order to investigate plasma total homocysteine ( tHCY ) level , its influential factors , and the relationship between total homocysteine ( tHCY ) and N 5 , N 10 - methylenetetrahydrofolate reductase ( MTHFR ) gene in hemodialysis patients .

错配杂交化学发光法检测亚甲基四氢叶酸还原酶基因多态性

Detection of methylenetetrahydrofolate reductase gene polymorphisms by chemiluminescence based on mismatch hybridization

贵州三个民族亚甲基四氢叶酸还原酶基因的遗传多态性

5,10-methylenetetrahydrofolate reductase polymorphism in three nationalities of Guizhou in China

脑梗死患者5,10-亚甲基四氢叶酸还原酶基因位点多态性的研究

Genetic polymorphisms of 5,10-methylenetetrahydrofolate reductase ( MTHFR ) in patients with cerebral infarction

胃癌亚甲基四氢叶酸还原酶基因多态性及其与微卫星不稳的关系

The relationship between methylenetetrahydrofolate reductase gene polymorphism and microsatellite instability in gastric cancer

河南汉族人群亚甲基四氢叶酸还原酶基因多态性检测

Polymorphisms of MTHFR among Han population in Henan area

动脉粥样硬化性脑梗死的亚甲基四氢叶酸还原酶基因多态性研究

Study on MTHFR gene polymorphism in atherosclerotic cerebral infarction

血清同型半胱氨酸水平及亚甲基四氢叶酸还原酶基因多态性与无症状性脑梗死的关系

Relationship of serum homocysteine levels and methylenetetrahydrofolate reductase gene polymorphisms with silent cerebral infarction

5,10-亚甲基四氢叶酸还原酶的基因组结构分析

Analysis of genomic structure of human 5,10-methylenetetrahydrofolate reductase

亚甲基四氢叶酸还原酶基因单体型与焦炉作业工人染色体损伤易感性的关系

Association between methylenetetrahydrofolate reductase gene haplotypes and the susceptibility of chromosomal damage in coke-oven workers

妊高征患者亚甲基四氢叶酸还原酶基因多态的检测亚甲基四氢叶酸还原酶基因多态性与宫颈癌易感性

Detection of methylenetetrahydrofolate reductase gene polymorphism Relationship between Methylenetetrahydrofolate reductase polymorphism and cervical cancer susceptibility

广西健康育龄妇女亚甲基四氢叶酸还原酶基因多态性与妊娠结局的关系

Association between the gene polymorphism of methylenetetrahydrofolate reductase and pregnant outcomes in Guangxi healthy women of reproductive age

酒精性股骨头坏死与亚甲基四氢叶酸还原酶677C/T单核苷酸多态性的关系

Relationship between alcohol induced osteonecrosis of femoral head and single nucleotide polymorphisms of methylene tetrahydrofolate reductase 677 c / t

叶酸受体α在胃癌组织中的表达及其与叶酸、亚甲基四氢叶酸还原酶基因多态性以及胃癌生物学行为的关系

Expression of Folate Receptor alpha and its Correlation with Folate , Methylenetetrahydrofolate Reductase Gene Polymorphisms and Biological Behaviour of Gastric Cancerous Tissue