亚砷酸钠

目的：体外培养人外周血淋巴细胞，探讨不同浓度的亚砷酸钠（NaAsO2）对淋巴细胞的生物学效应及作用机制，并观察亚硒酸钠（Na2SeO3）对砷毒性的拮抗作用。

Objective : To investigate the different dose sodium arsenite ( NaAsO_2 ) on lymphocyte biological effect and function mechanism , and the antagonism effects of selenium in vitro .

本文报告了亚砷酸钠和砷酸钠对中国地鼠卵巢细胞（CHO）的毒性和细胞遗传学效应。

The cytotoxic and cytogenetic effect of sodium arsenite and sodium arsenate on Chinese hamster ovary ( CHO ) cells is reported .

亚砷酸钠致脏器细胞DNA链断裂的实验研究

Study on DNA Strand Breaks in Different Organs Induced by NaAsO_2

姜黄素拮抗亚砷酸钠所致的DNA链断裂损伤

Antagonistic effect of curcumin on sodium arsenite induced DNA damage in mice

叔丁基对苯二酚对亚砷酸钠致changliver细胞毒性的影响

Antagonism of Tert-butylhydroquinone to Sodium Arsenite-Induced Cytotoxicity in Chang Liver Cells in vitro

活性氧在亚砷酸钠诱导Chang肝细胞凋亡中的作用

Reactive oxygen species play an important role in NaAsO_2-induced Chang liver cells apoptosis

叶酸对亚砷酸钠致Chang肝细胞毒性和氧化应激的影响

Effects of Folate on Sodium Arsenite-Induced Toxicity and Oxidative Stress in Chang Hepatocytes

免疫细胞化学法发现亚砷酸钠能显著上调细胞Caspase-3蛋白的表达。

Sodium arsenic up-regulated Caspase-3 protein expression in BGC-823 cells .

亚砷酸钠染毒对体外培养人淋巴细胞CAT及其基因表达的影响

The effects on the leave of CAT and the expression of its gene in human lymphocyte in vitro culture induced by sodium arsenic

黄磷亚砷酸钠四氯化碳肝损害LDH同工酶的比较研究

Comparison of Lactate Dehydrogenase Isoenzymes of Hepatic Injury Induced by Phosphorus , Sodium Arsenite and Carbon Tetrachloride

亚砷酸钠还可引起CHO细胞的姐妹染色单体互换率的增加和人类淋巴细胞染色体的断裂和畸变。

Sodium arsenite was also shown to produce increased sister chromatid exchange in CEO cells and increased chromosome breakage in human lymphocytes .

目的探讨亚砷酸钠对人胃癌细胞株BGC-823的作用机制。

Objective To investigate the antitumor mechanism of sodium arsenic on human gastric carcinoma cell line BGC-823 in vitro .

并通过测定硒多糖、亚砷酸钠对肝谷胱甘肽过氧化物酶（GSH－Px）和脂质过氧化（LPO）的影响，探讨了硒、砷相互作用的机理。

And the mechanism was also illuminated by determining their effects on the activity of glutathione peroxidase ( GSH Px ) and the lipid peroxidation .

方法原代培养皮肤成纤维细胞和表皮细胞，通过直接细胞计数法和噻唑蓝（MTT）还原法检测亚砷酸钠诱导对2种细胞系生长的影响。

Methods Cell number counting , MTT reduction assay , transmission electron microscope were performed in primary cultured skin cells , and sodium arsenite was used as tester inorganic arsenics .

方法采用MTT实验测定亚砷酸钠及氟化钠对正常人淋巴细胞的LC50，然后以此为依据制定试验剂量（LC50的1/100~1/10），观察低剂量氟、砷单独及联合作用对正常人淋巴细胞增殖的影响。

Methods The MTT test is applied to this study for observing the effect on the proliferation of human lymphocytes in vitro .

目的：体外观察亚砷酸钠、羟基喜树碱对人胃癌细胞株BGC-823、SGC-7901的联合效应，并探讨其作用机制。

Objective : To study the combined effect and antitumor mechanism of sodium arsenite and HCPT on human gastric carcinoma cell lines BGC-823 and SGC-7901 in vitro .

方法采用亚砷酸钠（Ars）在体外诱导ECs凋亡，应用流式细胞术测定凋亡细胞比例、细胞间黏附分子ICAM-1表达和细胞内氧化状态水平，以及NAC处理后上述指标的改变。

Methods Ars was used to induce ECs apoptosis in vitro . ECs apoptosis , ICAM-1 expression and oxidative state and their changes after NAC treatment were detected by flow cytometry .

目的观察不同剂量亚砷酸钠染毒大鼠肝细胞膜转运蛋白&多药耐药相关蛋白2（MultidrugResistance-AssociatedProtein2，MRP2）表达水平的变化及与砷代谢的关系。

Objective To explore the relationship between the expression of hepatic multidrug resistance-associated protein 2 ( MRP2 ) in rat correspondence with arsenite and arsenite metabolites .

研究了硒多糖、亚砷酸钠在体内、外对大鼠肝微粒体酶细胞色素P－450、b5、NAD（P）H－细胞色素C还原酶、谷胱甘肽硫转移酶（GST）的影响；

The effects of selenium polysaccharide and sodium arsenite on the contents of microsomal cytochrome P450 , b5 and activities of NAD ( P ) H cytochrome C reductase and glutathione S transferase in rat were studied in vivo and in vitro experiments .

亚砷酸钠致SV-HUC-1细胞氧化应激作用的研究

Oxidative Stress Induced by NaAsO_2 in SV-HUC-1 Cell

目的探讨亚砷酸钠（Na2AsO2）所致人胚肺成纤维细胞（HELF）增殖兴奋效应与氧化应激的关系。

Objective To investigate the relationship between the hormesis of proliferation and oxidative stress induced by sodium arsenite ( Na_2AsO_2 ) in human embryo lung fibroblasts ( HELF ) .

氢氧化铁凝胶与亚砷酸钠溶液混和后，溶液的pH值在6min内从9.71上升到10.36，原因是亚砷酸根离子置换了针铁矿和氢氧化铁中的氢氧根；

It was found that , due to the replacement of OH - by arsenite in goethite and Fe ( OH ) _3 , pH changed from 9.71 to 10.36 6 minutes after the Fe ( OH ) _3 gel was mixed with NaAsO_2 solution .

目的：了解亚砷酸钠亚慢性染毒对小鼠不同脏器组织脂质过氧化水平及抗氧化作用，探讨亚砷酸钠对谷胱甘肽S-转移酶（GST）活力及其基因表达的影响，分析GST活力与抗氧化能力的相关性。

Objective : To investigate the effects of sodium arsenite on lipid peroxidation and antioxidant in mice liver 、 kidney and brain ; To explorer Glutathione S-transferase ( GST ) activities and its genes expression , and to analyze the relationship between GST activities and the capacity of antioxidation .

方法以健康大白鼠30只，随机分为实验组和对照组，实验组皮下注射亚砷酸钠溶液（0.02mg/g），正常组皮下注射蒸馏水。

Methods 30 healthy white rats were randomly allocated to an experimental group and a control group . The experimental group were given subcutaneous injection with 0.02mg/g sodium arsenite solution , and the control group were given subcutaneous injection with distilled water .

亚砷酸钠对血红素加氧酶-1诱导作用

Sodium arsenite-induced expression of heme oxygenase-1 in bovine aortic endothelial cells

亚砷酸钠所致兴奋性效应与脂质过氧化的关系

The Relationship between Lipid Peroxidation and Hormesis Caused by Sodium Arsenite

亚砷酸钠和砷酸钠对细胞缝隙连接间通讯的影响

Effects of Arsenite and Arsenate on Gap Junctional Intercellular Communication

结论：亚砷酸钠可剂量依赖地诱导内皮细胞凋亡；

CONCLUSION : Ars can induce apoptosis of ECs dosage-dependently ;

亚砷酸钠治疗加速期慢性粒细胞性白血病的疗效观察

Arsenic trioxide therapy for chronic myelogenous leukemia in accelerated phase

亚砷酸钠对离体哺乳细胞遗传毒性作用研究

Studies of cytogenetic effects of sodium arsenicals on mammalian cells in vitro