马钱子碱

马钱子碱、砷和鸦片都是毒药。

Strychnine , arsenic , and opium are poison .

马钱子碱分子结构和振动光谱的密度泛函理论研究

DFT Study of Molecular Structure and Vibrational Spectrum of Strychnine

对软骨细胞DNA、蛋白多糖、胶原合成的影响：马钱子、马钱子碱高中剂量组有明显促进兔软骨细胞DNA合成及分泌蛋白多糖的作用，且有一定的量效关系。

The high and middle dosage of Semen strychni 、 Brucine could promote DNA and proteoglycan synthesis of chondrocyte apparently .

HPLC法测定马钱子碱固脂纳米粒冻干粉的包封率和载药量

Determination of Entrapment Efficiency and Drug Loading of Brucine Solid Lipid Nanoparticles Lyophilized Powder by HPLC

每天小鼠ip马钱子碱12mg/kg和可乐定100μs/kg，连续给药8天，镇痛作用不产生耐受性。

Daily ip brucine 12mg / kg and clonidine 100 μ g / kg × 8d in mice did not in - duce tolerance in terms of analgesic action .

建立了马钱子碱、士的宁的高效液相色谱（HPLC）含量测试方法，测定马钱子粉中马钱子碱、士的宁含量并对各组样品的微观形貌进行了扫描电镜（SEM）分析。

High performance liquid chromatography ( HPLC ) methods for determining brucine and strychnine were established . The microstructures of all samples were examined by scanning electronic microscope ( SEM ) .

为了控制毒性成分的含量，本研究采用HPLC法对士的宁碱和马钱子碱进行含量测定，并进行方法学考察，同时对马钱子不同炮制品所制成品中士的宁碱和马钱子碱含量进行比较研究。

The contents of strychnine and brucine and the methodology should be determined by HPLC to control the toxical components . Meanwhile comparative study of strychnine and brucine contents from different processed products was performed .

目的：马钱子碱（Brucine）为吲哚型生物碱，是马钱子的主要有效成份之一。

Objective : Brucine , a main component of nux vomica , is one of indole alkaloids .

P-gp抑制剂维拉帕米阻止了马钱子碱从脑部排出，由此可推断马钱子碱在小鼠体内可能是血脑屏障上P-gp底物。

Verapamil could reverse the decreased trend of drug disposition in brain , so brucine may be the substrate of P-gp in blood-brain barrier . 2 .

用细胞内微电极技术观察了马钱子碱（brucine）对离体豚鼠乳头肌高K＋除极异丙肾上腺素（Iso）和组织胺（His）诱发的慢反应动作电位（SAP）的影响。

The effects of Brucine were studied on the slow action potentials induced by isoprenaline and histamine in high K + depolarized guinea pig papillary muscles by means of conventional glass microelectrodes .

根据热力学参数确定马钱子碱与BSA之间的作用力类型主要为疏水性相互作用。

The process of binding was a spontaneous molecular interaction in which entropy increased and Gibbs free energy decreased , indicating that the interaction between brucine and BSA was driven mainly by hydrophobic force .

马钱子碱能还能提高小鼠的免疫器官的重量及其指数，但其对腹水瘤模型（EAC、Heps）荷瘤小鼠的生存时间无明显延长作用。

It could enhance the weight and index of immune organ . However , it had no obvious effect on prolonging the life of mice with transplanted tumor ( EAC 、 Heps ) .

结论：马钱子碱能有效促进软骨细胞增殖。

Conclusion : Brucine can effectively promote the proliferation of chondrocyte .

马钱子碱对裸鼠乳腺癌骨转移的实验研究

Experimental Study of Brucine on Breast Cancer Bone Metastasis in Mice

马钱子碱对豚鼠心脏乳头肌动作电位的影响

Effect of brucine on the action potentials in guinea pig papillary muscles

一种新的马钱子碱液膜电极的研制与应用

Preparation and application of a new STRYCHNINE-SELECTIVE liquid membrane electrode

目的：研究马钱子碱在小鼠体内的组织分布。

AIM : To study the tissue distribution of brucine in mice .

基于β&环糊精的马钱子碱超分子电化学传感器的研究

Super-molecule electrochemical sensor for the determination of brucine based on β & cyclodextrin

马钱子碱聚乳酸纳米粒在家兔体内的药动学研究

In vivo pharmacokinetics of brucine-loaded polylactide nanoparticles in rabbits

马钱子碱与异马钱子碱氮氧化物抗肿瘤细胞生长及抗氧化损伤作用的比较

Comparison of Brucine and Nitrogen Oxides Isobrucine in Their Anti-cancer and Anti-oxidation Effect

目的：考察马钱子碱经皮给药的镇痛作用。

Objective : To investigate the analgesic effect of brucine by transdermal administration .

复方马钱子碱的镇痛作用及其药效动力学初步观察

Analgesia and Pharmacodynamics of Compound Brucine Injection in Mice

结论复方马钱子碱腹腔注射有明显的镇痛作用，且起效迅速，作用强而持久。

Conclusion Compound brucine has remarkable analgesic effect with power potency and long duration .

结论该方法可望用于生物材料中的马钱子碱和士的宁的检测。

Conclusion This method can be used to detect brucine and strychnine in liver .

高效液相色谱法测定大鼠血浆中马钱子碱与血浆蛋白的结合率

Determination of the Plasma Protein Binding Rate of Plasma Brucine in Rats by HPLC

口服马钱子碱后小鼠体内的药动学研究

Study on Pharmacokinetics of brucine in mice

大白鼠马钱子碱惊厥与脑各部位氨含量关系的研究

The study of relations between ammonia content of brain and convulsion by strychnine in rats

目的建立骨康片中士的宁和马钱子碱的含量测定方法。

Objective To establish the analytical method of strychnine and brucine in Gukang tablet by TLC .

马钱子碱脂质体的大鼠离体透皮性能和兔皮肤刺激性研究

In vitro Transdermal Penetration of Brucine Liposomes in Excised Rats Skin and Irritation to Rabbits Skin

建立测定通痹灵片中马钱子碱、士的宁含量的方法。

To establish a method for the determination of brucine and strychnine contents in Tongbiling Tablet .