阿片肽

结论感觉、交感及副交感神经系统均参与偏头痛的发病，在此过程中有多种与血管舒缩有关的肽类含量改变，同时伴有部分内源性阿片肽的相关变化及β-EP的降低。

Conclusion The sensory , sympathetic and parasympathetic systems are involved in the development of migraine , there are changes of many kinds of neuropeptides levels relating to vasomotion , and with relative changes of parts endogenous opiate peptides in this disease , and the lowering of β EP .

结论PAG内OT在痛行为调制中发挥着重要的作用，并且此作用不完全依赖于内源性的阿片肽系统。

Conclusion These data suggest that OT in PAG plays an important role in the analgesia , and its effect is independent of endogenous opiate peptides .

强啡肽B是一种新发现的阿片肽。

Dynorphin B is a novel opioid tridecapeptide .

脊髓DAD2受体介导的抗炎症痛作用与中枢阿片肽系统的关系

Relationship between the Anti-hyperalgesic Effect Mediated by DAD_2 Receptors in the Spinal Cord and Central Opioid System

M-脑啡肽和两种内啡肽在未成熟B细胞上的效应能够被拮抗剂纳络酮所逆转，提示反应涉及阿片肽受体机制。

The effects of methionine-enkephalin and endorphins on immature B cells could be reversed by antagonist naloxone suggesting that opiates receptor mechanisms might be involved .

18月龄雌性大鼠下丘脑内源性阿片肽含量及其mRNA水平变化的研究

Aging changes in endogenous opioid peptides contents and mRNA levels of the hypothalamus in 18 month old female rats

结论：电针可能是通过内源性阿片肽抑制SP而产生镇痛作用。

Conclusion : Electroacupuncture might exert its analgesic effects through stimulating the internal opiate peptide to inhibit SP.

低、高频电针诱导原癌基因c－fos／c－jun和阿片肽基因表达及其关系的比较研究

Comparative Study on the Expression and Interaction of Oncogene c-fos / c-jun and Three Opioid Genes Induced by Low and High Frequency Electroacupuncture

目的观察雌激素对κ阿片肽受体（κOR）mRNA含量和蛋白表达的调节作用。

AIM : To observe the regulatory effect of 17 β - estradiol on the expression of kappa opioid receptor (κ OR ) mRNA and protein .

几种阿片肽及ACTH对小鼠腹腔巨噬细胞吞噬功能的作用

The effects of different opiate peptides and ACTH on the phagocytosis of mouse macrophages

内源性GABA对静息心血管功能的控制比内源性阿片肽强。

The endogenous GABA has a stronger action on resting cardiovascular function than the endogenous opioid peptides .

5-羟色胺2A受体在外周组织内源性阿片肽表达中的作用

The Contribution of 5-hydroxytryptamine 2A Receptors to the Expression of Endogenous Opioid Peptides in Peripheral Tissue

内源性阿片肽抑制颈动脉加压反应，内源性GABA增强此反应。

The endogenous opioid peptides inhibit the carotid artery occlusion pressor response , whereas the endogenous GABA enhances it .

脑缺血后内源性阿片肽（endogenousopioidpeptides，EOP）发生一系列变化，如β-内啡肽升高等；

Cerebral ischemia causes a series of endogenous opioid peptides ( EOP ) changes , including B - endorphine 's rising .

对电针镇痛的机理研究揭示，电针是通过激活机体内源性痛觉调制系统如内源性阿片肽和5-HT下行抑制系统而起镇痛作用。

EA plays its analgesic role via activating the endogenous pain modulating systems , including endogenetic opioid and serotonin descending system .

利用生物测定法测得兔耳动脉内源性阿片肽（OLS）的含量为377.2±118.0pg／mg组织湿重。

A mean value of opiate-like substances ( OLS ) in rabbit ear artery measured by bioassay was 377.2 ± 118.0pg/mg of wet tissue .

过去的工作已经证明八肽胆囊收缩素（CCK-8）能够对抗阿片肽的镇痛作用，本工作探讨CCK-8是否能够对抗阿片肽的心血管抑制作用。

Cholecystokinin-octapeptide ( CCK-8 ) has been shown to antagonize the an-algesia produced by opioid peptides .

若在icvSP之前，预先向第四脑室注射阿片肽受体拮抗剂纳洛酮（100～200μg），可增强SP引起的肺动脉和颈动脉升压反应。

Pretreatment of opioid receptor antagonist naloxone ( 100 ￣ 200 μ g ) by intracerebroventricular ( 4th ) injection could enhance the SP induced pulmonary and carotid pressor responses .

结论STC患者内源性阿片肽活性增加，肠道运动受抑制，提示阿片受体拮抗剂可能是治疗STC的一个新途径。

Conclusion It expressed that activity of endogenous opioid peptides was increased and the intestinal motility was inhibited in STC .

一氧化氮（nitrooxide，NO）、c-Fos蛋白、内源性阿片肽都表达于神经系统内，参与机体炎性疼痛的病理过程。

Nitro oxide ( NO )、 c-Fos protein and endogenous opioid peptide are present in the nervous system and involved in the pathological process of inflammatory pain .

阿片肽在后角镇痛的作用机理，被认为是通过突触前抑制一级传入纤维P物质释放的结果，然而始终未获得形态学的证实。

It has been suggested that the analgesic effect of opioid peptides in the dorsal horn is mediated by presynaptic mechanism to inhibit the release of substance P. However , ultrastructural data indicated that axo-axonal synapses between enkephalin and substance P terminals are unlikely .

结论纳洛酮通过竞争性拮抗内源性阿片肽受体，可能通过抑制Bax的表达来减少颅脑损伤后神经细胞的凋亡，发挥脑保护作用，其详细机理尚有待进一步研究。

Conclusion Naloxone maybe reduce the apoptosis of neuron after brain injury through the inhibiting express of Bax . But its detailed mechanism is still in need for further research .

TRH可阻断阿片肽的自主神经效应，而不影响痛觉。

Thyrotropin-releasing hormone ( TRH ) is a partial physiologic opiate antagonist that reverses the autonomic effect of opioids without altering analgesia .

以往的研究表明，内源性阿片肽（EOP）参与了EA对炎症痛镇痛的外周机制。

The previous studies suggested that endogenous opioid peptides ( EOP ) participate in the peripheral mechanism of electro-acupuncture ( EA ) analgesia for inflammatory-pain .

用固相法合成了内源性类阿片肽新皮啡肽I（DelI）及其3个类似物（Asp从5位到7位）。

Endogenous opioid deltorphin I ( DEL I ) and its analogues ( progressive , stepwise repositioning of Asp from 5 to 7 ) were synthesized by using solid phase method .

目的探讨中脑导水管周围灰质（PAG）内催产素（OT）在痛行为调制中的作用，及其与内源性阿片肽系统之间的关系。

Objective To study the effect of oxytocin ( OT ) on pain modulation in periaqueductal gray ( PAG ) and its relation to endogenous opiate peptides .

以往工作发现，中脑导水管周围灰质（PAG）和海马在非阿片肽ACTH痛觉调制中占有重要地位。

It was found previously that the periaqueductal gray ( PAG ) and hippocampus play important roles in pain modulation of ACTH , a non-opiate peptide .

NP2是一种表达天然阿片肽-脑啡肽的基因转运载体。

NP2 is a gene transfer vector that expresses the naturally-occurring opioid peptide enkephalin .

结果：与SR组相比，AF组κ-阿片肽受体mRNA表达量减弱[（262±20）∶（196±11），P<0.05]。

Results : Compared with the group of SR , the κ - opioid receptor mRNA amounts in AF significantly decreased [ ( 262 ± 20 ) vs. ( 196 ± 11 ), P < 0.05 ] .

人们早已知道内源性阿片肽（EndogenousOpioidPeptide，EOP）及阿片受体的存在，并已认识到其在中枢镇痛、中枢心血管功能调节等方面的作用。

The existence of Endogenous Opioid Peptide ( EOP ) has been known for a long time , and it has been recognized that EOP has a central paregoric effect and can regulate cardiovascular functions .