阿昔洛韦

目的建立阿昔洛韦片的溶出度检查方法。

Objective to establish a method to determine the dissolution of aciclovir tablet .

阿昔洛韦分散片的HPLC法测定

Determination of Aciclovir Dispersing Tablets by HPLC

阿昔洛韦眼用pH敏感原位凝胶剂的制备和评价

Preparation and evaluation of ophthalmic pH sensitive in-situ gel of acyclovir

HPLC法检查阿昔洛韦分散片的有关物质

HPLC for the determination of relative substances in Acyclovir dispersed tablets

HPLC法测定目安眼膏在家兔房水内阿昔洛韦的含量

Determination of Acyclovir in Muan eye ointment with HPLC in aqueous humor of rabbits

建立阿昔洛韦尿素乳膏中阿昔洛韦含量的HPLC测定方法。

A HPLC method was established for the determination of Aciclovir in Aciclovir urea cream .

方法：用HPLC法测定兔血浆中万乃洛韦的降解产物阿昔洛韦。

METHODS : HPLC was used to determine the concentration of ACV in rabbit plasma .

毒副作用：多烯康组为1例（1／39）少于阿昔洛韦组（8例，8／39），差异显著（P＜0.05）。

The adverse reaction rate ( 1 / 39 ) in Duo-xi-kang was less than that ( 8 / 39 ) in aciclovir ( P0.05 ) .

将21例丙型肝炎病毒（HCV）RNA阳性的丙型肝炎患者随机分成α-干扰素（IFN-α）联合阿昔洛韦（ACV）、单用IFN-α和支持治疗组。

Twenty-one patients with hepatitis C virus ( HCV ) RNA positive were divided into three groups .

阿昔洛韦胃黏附型缓释混悬剂Beagle犬体内药动学

Pharmacokinetics of stomach-bioadhesive acyclovir sustained-release suspensions in Beagle dogs

目的考察阿昔洛韦在PVC袋（聚氯乙烯输液袋）、三层复合膜输液袋及玻璃瓶中的稳定性是否存在差异。

OBJECTIVE To investigate the stability of acyclovir in PVC bags , three-layer plastic bags with the innermost layer made of polyethylene and glass containers .

方法报道3例阿昔洛韦诱导的ARF的临床表现，实验室检查及肾组织活检结果，并对相关文献进行复习。

Methods Three cases with Acyclovir induced ARF were reported retrospectively and the related literature were reviewed .

方法：35例生殖器疱疹随意分为2组。A组用阿昔洛韦，B组用万乃洛韦治疗。

Methods : 35 cases with GH ware devided into 2 groups , group A treated by ACV and group B by VCV . The treatment response , duration of lesion clearance have been investigated .

结果合成了11个未见文献报道的6O取代苯基阿昔洛韦衍生物，其结构均经元素分析、1HNMR和MS确证。

Results Eleven new compounds were synthesized , and their structures were all confirmed by the elemental analysis , 1H-NMR and MS detection .

其口服生物利用度比阿昔洛韦强，已经FDA批准用于治疗带状疱疹和原发、复发性生殖器疱疹。

It is developed by Glaxo Wellcome company and approved by FDA for treatment of herpes zoster , and first or reccurrent episodes of genital herpes .

目的：考察（25±5）℃下，注射用阿昔洛韦与头孢拉定在0.9%氯化钠注射液（NS）中的配伍稳定性。

Objective : To examine the stability of compatibility of aciclovir sodium for injection and cefradine in normal saline ( NS ) at 25 ± 5 ℃ .

阿昔洛韦治疗组小鼠死亡率、血清NO及IL-1β水平均比未治疗组明显降低，差异有显著性（Pa<0.01）；

The mortality rate , NO and IL-1 β levels in blood in acyclovir-treated group were obviously lower than those of untreated group ( Pa < 0.01 ) .

本论文以阿昔洛韦（Acyclovir，ACV）为原料与棕榈酰氯反应合成了阿昔洛韦棕榈酸酯（AcyclovirPalmitate，ACVP）。

Acyclovir palmitate ( ACVP ) was synthesized from acyclovir ( ACV ) and palmitoyl chloride .

rhIFNα2a凝胶与阿昔洛韦的疗效差异无显著意义。

The curative effect of rhIFN α 2 a gel showed no significant difference with that of acyclovir .

目的：研制一种具有较好生物粘附能力和药物缓释效果的阿昔洛韦（Acv）卡波姆（Cb）乙基纤维素（Ec）微球。

OBJECTIVE : To prepare aciclovir ( Acv ) carbomer ( Cb ) ethylcellulose ( Ec ) microspheres with good bioadhesion and sustained drug release .

结论阿昔洛韦联合IVIG治疗能缩短Kaposi水痘样疹的自然病程，疗效佳，且耐受性好。

Conclusion Acyclovir combined with IVIG is an effective and easily tolerated method to treat Kaposi 's varicelliform eruption .

实验方法采用RP-HPLC法测定6条健康beagle犬单剂量口服阿昔洛韦缓释片与普通片后，阿昔洛韦的血药浓度变化。

METHODS Blood concentrations of Acyclovir were determined by RP-HPLC after a single oral dose of two kinds of Acyclovir tablet was given separately to 6 beagle dogs .

结论目前在南京地区收集的HSV-2型毒株对阿昔洛韦和伐昔洛韦敏感性较高，尚未发现耐药株。

Conclusions All the 15 HSV-2 strains isolated in Nanjing are highly sensitive to acyclovir and valaciclovir , and no drug-resistant strains are found .

方法：查阅国内、外文献以及我国和世界卫生组织药品不良反应监测中心数据库，分析《ADR信息通报》发布的阿昔洛韦安全性监测情况及不合理用药现状。

METHODS : Through the research of domestic and overseas literatures , WHO and national ADR database to analyse the causes of the bulletin of acyclovir and current situation of unreasonable drug use .

目的：观察阿昔洛韦（无环鸟苷，Aciclovir，ACV）治疗小儿水痘的疗效。

To observe the curative effect of aciclovir ( ACV ) on chicken pox in children , the two different treatment methods were compared .

目的建立HPLC法测定目安眼膏在家兔房水内阿昔洛韦（ACV）含量的方法，为目安眼膏在兔眼内转运动力学研究提供定量方法。

Objective To set up a method to determine the concentration of Acyclovir ( ACV ) in Muan eye ointment with HPLC for the study of the ointment pharmacokinetics in rabbit aqueous humor .

阿昔洛韦（ACV）为核苷类抗病毒药物，对病毒感染细胞有高度亲和性，而对正常细胞毒性甚微。

Acyclovir ( ACV ), an antiviral agent of nucleoside , has highly selective activity against virus infective cells and virtually non-toxic to human normal cells .

治疗上除充分补液、碱化尿液和加强利尿外，加用前列腺素E1脂微球制剂（lipoPGE1），有病毒感染者予阿昔洛韦或更昔洛韦治疗。全部病例经上述处理均获痊愈。

Hyperhydration , alkalinizing and diuresis plus Lipo prostaglandin E 1 ( Lipo PGE 1 ) or anti-virus drug were the main treatment measure , and all patients were cured .

目的设计合成6O取代苯基阿昔洛韦衍生物，并进行抗病毒活性测定。

Aim To design and synthesize 6-O-substituted phenyl derivatives of aciclovir ( ACV ), and to test their antiviral activities .

方法21例年龄在2个月~3岁的Kaposi水痘样疹患儿，随机分为阿昔洛韦治疗组和阿昔洛韦联合IVIG治疗组。

Methods Twenty-one children with Kaposi 's varicelliform eruption were divided into two groups : one was treated only with acyclovir , the other was treated with acyclovir and IVIG .