错配修复

DNA错配修复系统不仅通过矫正在DNA重组和复制过程中产生的碱基错配而保持基因组的稳定，而且通过诱导DNA损伤细胞的凋亡而消除由突变细胞生长形成的癌变。

DNA MMR system not only ensures the precision of chromosomal replication and maintains genomic stability by correcting the mismatches during the replication and recombination , but also eliminate cancer cells by promoting apoptosis of cells with severely damaged DNA .

错配识别蛋白MutS是错配修复系统行使修复功能的第一个蛋白，具有识别并结合错配的能力。

DNA mismatch binding protein MutS , is the first protein which initiate the function of MMR . MutS has the ability to recognize and binding mismatched base pair .

DNA错配修复系统基因多态性与大肠癌易感

Polymorphisms of the DNA Mismatch Repair Genes and Susceptibility to Colorectal Cancer

DNA错配修复基因甲基化在肝细胞癌发生发展中的作用

Methylation of mismatch repair gene ( MMR ) in primary hepatocellular carcinoma

幽门螺杆菌与DNA错配修复系统

Relationship between Helicobacter pylori and DNA mismatch repair system

DNA错配修复与癌症的发生及治疗

DNA mismatch repair and occurrence and therapy of cancer

缺损DNA错配修复决定一个近侧结肠癌特异的转录模式

Defective DNA mismatch repair determines a characteristic transcriptional profile in proximal colon cancers

DNA错配修复系统研究进展

Advances of Researches on DNA Mismatch Repair System

DNA错配修复、染色体不稳定和肿瘤的关系

DNA Mismatch Repair , Chromosome Instability and Cancer

DNA错配修复基因产物表达与肿瘤恶性程度相关性的初步探讨

The preliminary research of significance of DNA mismatch repair gene product expressions in tumor cells

DNA错配修复基因hMSH2蛋白表达与胃癌发生关系的探讨

Study of relationship between expression of DNA mismatch repair gene hMSH_2 and generation of gastric cancer

微卫星不稳定性可间接反映DNA错配修复系统功能的缺陷。

Microsatellite instability can thus reflect the deficiency in DNA mismatch repair system to some extend .

对结肠癌DNA错配修复基因突变携带者的识别及存活率的评估

Identification and survival of carriers of mutations in DNA mismatch - repair genes in colon cancer

DNA错配修复系统可以识别并修复这种错误，对维持微卫星长度稳定相当重要。

DNA mismatch repair system is one of the systems in maintaining the length of Microsatellites loci .

青年人结直肠癌DNA错配修复基因表达和DNA倍性检测

The expression of DNA mismatch repair genes and detection of DNA ploidy in young patients with colorectal carcinoma

5-氮-2′-脱氧胞苷对人卵巢癌细胞凋亡及DNA错配修复基因表达的影响

Effects of 5-aza-2 ' - deoxycytidine on apoptosis of ovarian cancer cells and on expression of mismatch repair genes

子宫颈癌错配修复基因产物与p53表达

Mismatch Repair Gene Protein Product and the p53 Expression in Cervical Squamous Cancer

其中腺嘌呤甲基化在原核生物限制-修饰系统、DNA复制、DNA错配修复和基因表达调控中发挥着重要的作用。

Adenine methylation plays important roles in restriction-modificaton system , DNA replication , DNA mismatch repair and gene expression regulation in prokaryotes .

异源双链DNA体外错配修复功能检测模型的构建及弥漫性大B细胞性淋巴瘤中错配修复系统的分析

Construction of Heteroduplex DNA and in Vitro Model of Functional Analysis of Mismatch Repair as Well as Its Application in the Diffuse Large B Cell Lymphoma

目的建立一种以多重PCR-高效液相色谱（Highperformanceliquidchromatography，HPLC）分析为基础的错配修复基因DNA大片段缺失检测技术。

Objective Establishing a new method on the basis of multiplex PCR-high performance liquid chromatography ( HPLC ) for screening a large deletion in mismatch repair genes .

幽门螺杆菌对AGS细胞DNA错配修复基因表达的影响

Effects of Helicobacter pylori on expression of DNA mismatch repair genes in AGS cell line

针对不同的DNA损伤。细胞内有许多不同的修复方式对其进行修复，包括碱基切除修复、核苷酸切除修复、错配修复、同源重组修复等。

There are many DNA repair pathways to different DNA lesions , including base excision repair , nucleotide excision repair , mismatch repair and homologous recombination repair .

DNA错配修复基因mutS的高效表达及表达产物活性鉴定

High Expression and Identification of DNA Mismatch Repair Gene mutS in Escherichia coli

错配修复系统广泛的存在于生物体中，由于这个系统的存在保证了DNA复制过程中的保真度。

Mismatch repair systems exist in a wide range of organisms , due to the existence of this system to ensure that the process of DNA replication fidelity .

噬菌体展示技术筛选DNA错配修复蛋白MutS高亲和性抗体

High affinity antibody on DNA mismatch repair protein MutS through method of phage display

DNA错配修复基因MutS的克隆和表达

Cloning and expression of mismatch repair gene MutS

用RTPCR方法监测5种人类错配修复基因在膀胱癌细胞系mRNA转录水平的表达；

The expression of mRNA by RT PCR of 5 human mismatch repair ( MMR ) genes in bladder tumor cell line was evaluated .

PCR-SSCP银染法在检测错配修复基因突变中的应用

The application of detecting mismatching repair gene mutation by the method of PCR-SSCP

MNNG诱发的遗传不稳定vero细胞中错配修复功能的研究

Mismatch repair in MNNG-induced genetically instable monkey kidney Vero cell

有报道指出位于脆性位点的基因由于对DNA双链断裂及错误修复较为敏感，因而可能在错配修复缺陷肿瘤中成为损伤的靶目标。

It is reported that the gene at fragile site is susceptible to DNA double strand breaks and misrepair , so it could be the target of damage in mismatch repair deficient tumors .