链体

G-四链体DNA以其独特的结构及生理学功能为目前抗肿瘤药物研发提供了一个新的契机。

Currently , G-quadruplex DNA structure and its unique physiological function provide a new opportunity for the development of anticancer drugs .

本论文采用电化学方法，结合光谱方法，主要研究了二萘嵌苯类化合物的性质，及此类化合物与G-四链体DNA之间的相互作用，获得结合模式、结合常数等热力学参数。

In this paper , several electrochemical methods were used to study the interactions between G-quadruplexes DNA and derivations of perylene , and binding constants were obtained .

因此TPM染料可以开发为G-四链体识别荧光探针。

Thus , TPM dyes may be developed as sensitive G-quadruplex fluorescent probes .

研究发现，人体基因组中存在大量富含G的序列，它们能够形成稳定的G-四链体结构，参与着众多重要的生理过程，G-四链体也因此作为某些疾病的治疗靶点被大量研究。

There are a lot of G-rich sequences in the human genome which can form G-quadruplex and play an important role in a number of important physiological processes .

本文考察了五种TPM染料和G-四链体、双链和单链DNA作用后的荧光光谱和荧光共振能量转移光谱。

Here , fluorescence spectra and energy transfer spectra of five TPM dyes in the presence of G-quadruplexes , single-or double-stranded DNAs were compared .

金属配合物键合和稳定G-四链体DNA的性质，在癌症治疗中有重要意义，因为它可以通过这种方式来调控原癌基因的转录水平、抑制端粒酶活性和癌细胞的增殖。

Matal complexes that bind and stabilize G-quadruplex DNA structures are of significant interest due to their potential to regulate the proto oncogene transcription , inhibit telomerase activity and halt tumor cell proliferation .

结果表明四种TPM染料的荧光光谱可用于区分分子内G-四链体和分子间G-四链体、单链和双链DNA。

The results show that the fluorescence spectra of four TPM dyes can be used to discriminate intramolecular G-quadruplexes from intermolecular G-quadruplexes , single-and double-stranded DNAs .

TPM染料的荧光共振能量转移光谱和荧光共振能量转移滴定可把G-四链体（包括分子内G-四链体和分子间G-四链体）与单链和双链DNA区分开。

The energy transfer fluorescence spectra and energy transfer fluorescence titration can be used to distinguish G-quadruplexes ( including intramolecular and intermolecular G-quadruplexes ) from single-and double-stranded DNAs .

当没有输入时，TPM染料／G-四链体配合物显示很强的荧光，此时的输出信号为1。

The formation of the TPM dye / G-quadruplex complexes rendered the dye greatly enhanced fluorescence signal and the output signal of the gate was 1 .

基于Ag+和Cys对TPM染料／G-四链体配合物的荧光调制作用，此体系还可以用于Ag+和Cys的高特异性均相检测。

In addition , the modulation of the fluorescence of the TPM dye / G-quadruplex complexes by Ag + or / and Cys can also be used to develop highly selective homogenous sensing methods of Ag + and Cys .

端粒酶抑制剂的研究&与G-四链体相互作用的菲啶衍生物的设计、合成与生物活性研究

Design , Synthesis and Evaluation of Phenanthridine Derivatives Interacting with G-quadruplex as Telomerase Inhibitors

以G-四链体为靶点的小分子端粒酶抑制剂研究进展

Progress in the Study of G-quadruplex-targeted Telomerase Inhibitors

二酰亚胺类G-四链体配体抑制白血病细胞增殖及其分子机制

Inhibition Effect of Diimide G-quadruplex Ligand on Proliferation of Leukemia Cells and Its Molecular Mechanisms

人体端粒中（3+1）混合结构G-四链体稳定性的分子动力学模拟

Molecular Dynamics Simulations on the Stability of ( 3 + 1 ) Mixed-Type Hybrid G-quadruplex in Human Telomere

四角瑞利绦虫链体相对较长，头节及吸盘均呈椭圆形，颈部尤为细长；

However , the scolex and suckers of R.tetragona were oval in shape , and the neck was long and thin .

结论在体外，K+、Na+可诱导含端粒重复序列的核苷酸形成鸟嘌呤四链体结构。

[ Conclusion ] Both K + and Na + are able to induce the oligonucleotides containing telomeric repeats to form G-quadruplex structure in vitro .

叙述二种综虫体表的沟纹、微毛、顶突、吸盘、覆叠链体、感觉器等的特征和分布情况。

Some features and distribution of the grooves on the tegument , microtrichia , rostellum , suckers , craspedotes , and sensilla of the adults were observed .

供当链体解的动态庞纯性研讨反在供当链管理外现的尤为从要，而信做传收非影响供当链体解动态特征的从要果荤。

Dynamic complexity of supply chains is particularly important , and the transmission of information is the important factor which affects the supply chain system dynamic characteristics .

在去年这个团队通过从长毛象毛发中提取线粒状基因研究获得了第一次突破。这种线粒状基因物质是从雌性链体上遗传下来的。

The team made a first breakthrough last year by using mammoth hair to extract mitochondrial DNA , genetic material that is inherited from the female line .

然而当它们堆积在G-四链体的两个表面G-四分体时，由于共振被限制，它们的荧光显著增强。

However , when they stack onto the two external G-quartets of a G-quadruplex ( especially intramolecular G-quadruplex ), such vibrations will be restricted , resulting in greatly enhanced fluorescence intensities .

这种钾离子定量检测方法是基于某些CV/G-四链体配合物在K+和Na+中存在不同的荧光信号，且荧光信号随K+浓度改变而变化而建立起来的。

This method is based on the fluorescence difference of some CV / G-quadruplex complexes in the presence of K + or Na + , and the fluorescence change with the variation of K + concentration .

G-四链体由于能够抑制端粒酶的活性而成为抗肿瘤药物的新靶点，能促使G-四链体形成或稳定该结构的物质则可能对癌症有潜在的治疗意义。

Considerable circumstantial evidence suggests that telomerase activity can be directly inhibited by formation of G-quadruplex structures . The substances that can promote the formation and stabilize the G-quadruplex structures have potential uses for the cure of cancer .

以水生生态模拟系统研究了不同水生生物对钷（~（147）Pm）的富集性及其通过食物链鱼体的生物放大作用。

Bioconcentration and magnification properties of 147Pm ( RE ) on fish in the aquatic food chain are studied by aquatic ecosystem model .

结论：该现象是由于PEG链对体相中阿霉素或土霉素的吸附而引起的；

Conclusion : The reason for the phenomenon was the absorption of adriamycin or oxytetracycline molecules to PEG chains where multiple hydrogen bonds might be formed .

原发性肝癌患者血清及癌组织GPDA糖链异质体的研究

Study on the glycoforms of GPDA in the serum and liver tissues in patients with PHC

方法应用琥珀酸脱氢酶（SDH）组织化学染色分析其4型肌纤维构成比例与横切面积，并以十二烷基硫酸钠-聚丙烯酰胺小孔梯度凝胶电泳（SDS-PAGE）检测肌球蛋白重链异构体。

Methods Succinate dehydrogenase ( SDH ) staining was applied to analyse the proportions of muscle fibers of four types and sodium dodecyl sulphate-polyacrylamide gel electrophoresis ( SDS-PAGE ) was also used to measure myosin heavy chain isoforms ( MHCs ) .

形成丙型肝炎病毒负链复制体的相关蛋白的分析

Studies on the Proteins Related to the Replica of Hepatitis C Virus Negative-Strand RNA

作者运用代数动力学方法，计算了3粒子海森堡自旋链多体系统的几何相位。

Using algebraic dynamics , the geometric phase of a 3-particle spin chain has been calculated .

综述了利用含膦酰基的开链前体合成子通过环合成来获得膦酰基杂环化合物的各种方法。

This review deals with the progress in the studies of the synthetic methods of phosphonyl heterocyclic compounds .

一旦除去亚硫酸钠和四硫硫酸钠，冷冻干燥后，A链单体大部分转变成二体。

After the removal of the sulfite and tetrathionate by dialysis and lyophilization , the A-chain monomer was transformed gradually into the dimer .