银环蛇毒素

α-银环蛇毒素基因在两种不同表达载体中的表达

Expression of recombinant α - bungarotoxin in two different vectors

α-银环蛇毒素对中枢烟碱诱发小鼠惊厥效应的影响

Effect of α - Bungarotoxin on the Convulsion Induced by Intraventricular Injection of Nicotine in Rats

结果：六烃季铵（C6）和Kappa-银环蛇毒素（κ-BTX）明显抑制小鼠被动回避条件反应的获得，且κ-BTX的作用有量效关系。

RESULTS : Hexamethonium ( C6 ) 7 μ g / mouse and kappa-bungarotoxin ( k-BTX ) 0.6 μ g / mouse inhibited the acquisition of avoidance conditioning in mice , and k-BTX yielded this effect with a dose-response relationship .

通过对3株抗乙酰胆碱受体（AChR）的α－银环蛇毒素（α－BT）结合区抗体的配位特异性测定和可变区基因序列分析，探讨重症肌无力（MG）的发病机制。

The sequence analysis and paratope mapping of three antibodies against α - bungarotoxin (α - BT ) binding sites on acetylcholine receptor ( AChR ) were studied .

表达产物纯化、复性后经动物毒性试验表明：表达的α-银环蛇毒素蛋白具有生物学活性，小鼠腹腔注射其LD50约为1.28μg/g。

In vivo toxicity assay of purified and renatured proteins in mice showed that LD_ ( 50 ) was about 1.28 μ g / g.

每只实验组小鼠每次注射溶于1.3ml完全福氏佐剂中的20μg从小牛膈肌纯化的β-银环蛇毒素结合蛋白，而每只对照组小鼠则只注射同容积上述佐剂。

β - Bungarotoxin binding protein in dose of 20 μ g dissolved in 1 . 3 ml complete Freund adjuvant was injected into each mouse of the experimental group , whereas the same amount of the adjuvant only into each mouse of the control group .

~（125）I-α-银环蛇毒素的制备

The preparation of ~ ( 125 ) I - α - Bungarotoxin

银环蛇毒素及其基因工程研究进展

Advances of Research of Snake Venom from Bungarus Multicinctus and Genetic Engineering

重组α-银环蛇毒素的纯化及活性分析

Purification and biological activity of the recombinant α - bungarotoxin

K-银环蛇毒素对小鼠被动学习和空间记忆的影响

Effects of Kappa Bungarotoxin on Avoidance Learning and Spatial Memory Abilities in Mice

α-银环蛇毒素基因的克隆及其非融合型原核表达

Cloning of Alpha - Bungarotoxin Gene and Its Prokaryotic Expression as a Non-fusion Protein

α-银环蛇毒素基因的合成与表达

Cloning and Expression of α Bungarotoxin Gene

用β-银环蛇毒素结合蛋白免疫小鼠复制的具突触前变化的重症肌无力动物模型

Experimental Allergic Myasthenia Gravis with Presynaptic Changes in Mice Induced with β - Bungarotoxin Binding Protein

~（125）I-α-银环蛇毒素皮下吸收的研究

Study on absorption of ~ ( 125 )ⅰ - α - bungarotoxin in the subcutaneous tissues

β-银环蛇毒素结合蛋白抗体和乙酰胆碱受体抗体亲和性及其在重症肌无力致病中的意义

Affinity Distribution of Antigen-Specific IgG in Rats Immunized with Acetylcholine Receptor and β - bungarotoxin Binding Protein

阳性对照组：异硫氰酸荧光素标记的α-银环蛇毒素（FITC-α-Bgt）标记巨噬细胞；

Positive control : macrophages treated with FITC labeled α - Bgt ( FITC - α - Bgt ) .

增溶抽提β－银环蛇毒素结合蛋白及某些突触前毒素对其结合的抑制作用

Solubilization of β - bungarotoxin-binding protein from rat diaphragm and inhibition of its binding by some other presynaptic neurotoxins

用测定N-末端氨基酸，氨基酸成分，等电点和聚丙烯酰胺凝胶电泳进行纯α-银环蛇毒素的鉴定。

The purified a-BTX was identified by determining its N-terminal amino acid , amino acid composition , isoelectric and polyacrylamide gel electrophoresis .

鸡烟碱样胆碱能受体与[~（125）I]-α-银环蛇毒素结合动力学的研究

Studies on kinetic properties for binding of [ ~ ( 125 ) I ] - α - bungarotoxin to nicotinic ACh receptors from chick

小鼠化学法镇痛试验显示，重组α-银环蛇毒素有一定的镇痛药效，1/4LD50剂量的镇痛百分率为55.2%，1/8LD50剂量的镇痛百分率为20.5%，在外周镇痛作用中呈一定的量效关系。

Analgesis percentages with doses of 1 / 4 LD_ 50 and 1 / 8 LD_ 50 were 55.2 % and 20.5 % respectively , indicating that recombinant α - bungarotoxin possesses analgesic efficiency .