钙通道

一类新型N型钙通道阻滞剂的比较定量构效关系研究

Comparative QSAR Study on a Novel Class of N-type Calcium Channel Blocks

齐墩果酸型人参皂甙R0对心肌细胞单钙通道活动与自由基含量的影响

Influence of oleanolic acid type ginsenoside Ro on single calcium channel activity and free

N型电压依赖性钙通道（VDCCs）在疼痛的传递与调控中具有重要作用。

N-type voltage-dependent calcium channels are critical for pain transduction and modulation .

P型和Q型钙通道的性质差异及其可能的结构基础

Differences in the properties between P-and Q-type calcium channels and their presumable structural relevance

泮库溴铵对大鼠颈上交感神经元全细胞N型钙通道电流的影响及其机制的探讨

Effects of Pancuronium on Whole - cell N-type Calcium Currents of Rat Superior Cervical Ganglia

新的钙通道突变预示发作性共济失调患者的RNA异常剪接

New calcium channel mutations predict aberrant RNA splicing in episodic ataxia

这些研究结果可为设计更高活性的N型钙通道阻滞剂提供有价值的参考信息。

These research results can provide valuable information for designing potent N-type calcium channel blocks with high affinity .

用同属兴奋性神经毒的谷氨酸可通过受体依赖性钙通道使脑细胞胞浆游离钙增多（P＜0.05）。

In addition , glutamate , as an excitotoxin , though receptor dependent calcium channel increased [ Ca 2 + ] I in brain cells ( P < 0.05 ) .

影响Ca~（2+）代谢和钙通道的药物对小麦受叶锈菌侵染后诱发的HR的作用

The role of drugs affecting calcium metabolism and calcium channel on HR induced by wheat leaf rust fungus

钙通道阻滞剂和硝酸盐是用来降低LES压力。

Calcium channel blockers and nitrates are used to decrease LES pressure .

因此EA的扩血管机制与其对钙通道阻断作用有关。

The mechanism of vasodilatation of EA is related to its antagonistic effect to calcium ion .

西洋参茎叶皂甙单体Rb3对大鼠血流动力学及单钙通道活动的影响

Influence of panax quinquefolium saponin monomer Rb_3 on hemodynamics and single calcium channel activity in rats

AngⅡ对人心房肌细胞膜钙通道电流的影响及卡维地洛的拮抗作用

Effects of Angiotensin ⅱ on Calcium Channel Current of Human Atrial Myocyte and Its Antagonism by Carvedilol

钙通道阻滞剂Nifedipine对自发性高血压大鼠血管内皮细胞的保护作用

Protective effect of calcium channel blockers Nifedipine on vascular endothelial cells for spontaneous hypertension in rats

CaV2.3电压门控性钙通道与癫痫

Ca_V 2.3 voltage-gated calcium channel and epilepsy

分离平滑肌细胞用膜片钳记录钙通道电流，观察BK对单个平滑肌细胞的影响。

Record the influence of BK in single smooth muscle cell by patch clamp amplifer .

扩张型心肌病患者抗ADP／ATP载体抗体对心肌细胞电压依赖性钙通道活性的影响

Effect of autoantibodies against ADP / ATP carrier from patients with dilated cardiomyopathy on activity of voltage-dependent Ca channel in cardiac myocytes

ACh敏感性钾电流对钙通道阻断剂Cd2+敏感。

In addition , the calcium channel blocker , Cd ~ 2 + , inhibited the ACh-sensitive potassium current .

用膜片钳技术的全细胞方式在培养大鼠脑皮层神经元胞体膜上记录到电压依赖性钙通道电流（ICa）。

The voltage dependent calcium current ( ICa ) in cultured neurons from neonatal rat cortex was recorded with whole cell patch clamp technique .

目的：用P-gp的底物~（99m）Tc-MIBI评价中药钙通道阻滞剂川芎嗪（TMP）对乳腺癌MCF-7/ADR细胞耐多药的逆转作用。

Objective : To evaluate the reversal effect of MDR of MCF-7 / ADR cell by TMP with 99m Tc-MIBI .

目的：观察内毒素（LPS）刺激后大鼠肝致炎/抗炎细胞因子的表达，及钙通道阻滞剂（维拉帕米）在内毒素诱导的肝急性反应中对炎症因子的调控作用。

Objectives : To evaluate the effect of calcium channel blocker ( verapamil ) on pro-inflammatory and / or anti-inflammatory cytokines in liver and systemic circulation .

目的：研究二氢吡啶类钙通道阻滞剂尼卡地平对大鼠戊四唑（PTZ）化学性点燃（kindling）的拮抗作用。

Objective : To study the antagonism of dihydropyridine calcium channel blocker nicardipine against pentylenetetrazol ( PTZ ) kindling .

电压依赖性钙通道（voltagedependentCalCiumChannel，VDCC）是控制Ca~（2+）跨膜内流的主要途径之一，现已清楚精母细胞及精子上主要存在T型Ca~（2+）通道。

The voltage dependent calcium channels is one of main paths to controlling Ca2 + influx and T-type Ca2 + channel is the main Ca2 + current carrier in mouse spermatocyte and sperm .

采用兔肠缺血－再灌注模型，观察能量制剂ATP－MgCl2和钙通道阻滞剂维拉帕米（verapamil）对缺血小肠能量代谢的保护。

A rabbit model was established to study the protective effects of ATP-MgCl_2 and verapamil on intestinal energy metabolism following the ischemic insult .

钙通道阻滞剂（CCB）有一定的抗纤维化作用，同时能降低门静脉及食管曲张静脉的压力，减少门脉系统的血流量。

Calcium channel blocker ( CCB ) also has some anti-fibrosis effect . It has been used for portal hypertension and esophageal varices .

近年来，钙通道阻滞剂（CCB）与化疗药物联合应用的研究日益增多。

Recently , the study of the combination Ca2 + channel block ( CCB ) with chemotherapeutics in the anticancer effect is increased increasingly .

结论：NDK可能通过调节钙通道而抑制胸主动脉血管环收缩。

Conclusion : Nuodikang could inhibit the contraction of the vascular rings through adjusting calcium channels .

结果：杭州地区的钙通道拮抗剂的用药金额约占抗高血压药总金额的53.04%，血管紧张素转换酶抑制药约占16.36%，血管紧张素II受体拮抗药约占19.08%。

RESULTS : The sales volume of calcium channel blocker in Hangzhou has accounted for 53.04 % , ACEI accounted for about 16.36 % and angiotensin n acceptor antagonistic drug accounted for about 19.08 % of the total consumption .

因此，β细胞膜上钙通道动力学特性的变化可能是宫内营养不良导致成年后SGA大鼠胰岛β细胞分泌功能下降的一个重要原因。

Hence , the change of kinetics may be the reason that intrauterine malnourishment lead to the decrease of insulin secretion in adult life .

结论：肺静脉和心房组织L型钙通道蛋白表达的改变可能参与了肺静脉源性房颤的发生和维持，该通道功能的改变可能是肺静脉源性房颤的发生机制之一。

That functional change of channel maybe one of mechanisms of atrial fibrillation of pulmonary vein source .