钙离子通道

设计并合成了5个哌嗪取代二氢吡啶新衍生物，并用45Ca跨膜内流动测定方法研究了目标物对大鼠主动脉电压依赖性钙离子通道（PDC）Ca2+内流的影响。

Five new piperazine substituted dihydropyridine derivatives were designed and synthesized . Their inhibitive effects on potential dependent calcium ion channels ( PDC ) in rat aorta were determined by 45 Ca transmembrane influx technique .

通过对神经细胞钙离子通道的阻滞作用，减少或延缓神经细胞的凋亡发生，抑制早快基因的异常表达；

Blocking the calcium ion channels and delaying or inhabiting the occurrence of apoptosis of nerve cells ;

酵母双杂交文库筛选及N型钙离子通道与BART相互作用的初步分析

Yeast Two-Hybrid Screening Assay and Preliminary Analysis of the Interaction Between N-type Calcium Channel and BART

抗胚胎小鼠心肌α1D钙离子通道抗体的制备及鉴定

Preparation and Identification of Polyclonal Antibody of Mouse Embryonic Cardiac Calcium Channel α 1D

目的：观察钙离子通道阻滞剂盐酸维拉帕米对3T3鄄L1前体脂肪细胞分化及脂质积聚的影响。

Objective : To observe the effect of verapamil on the differentiation and the lipid accumulation of3T3-L1 preadipocyte .

结果：未分化的SHSY5Y细胞存在钙离子通道电流；

Results : There are voltage gated calcium currents in undifferentiated SH SY5Y cell line .

用hCG、ATP刺激Leydig细胞时细胞外液Ca~（2+）浓度的变化对钙离子通道反应的影响

Effect on the reaction to the calcium channel by the changes of calcium concentration in the extracellular fluid of Leydig cells when stimulated by hCG and ATP

方法：通过膜片钳手段，测量未分化的SHSY5Y细胞钙离子通道电流；

Methods : By using patch clamp technique , measure voltage gated calcium currents in undifferentiated SH SY5Y cell line .

结论：SO2具有明显的舒张血管平滑肌作用，其作用机制与钙离子通道及KATP通道有关，推测机体内源性SO2具有血管功能调节意义。

Conclusion : SO_2 could relax vascular smooth muscles , and the mechanism might be associated with calcium channels and K_ ( ATP ) channels , suggesting that endogenous SO_2 could modulate the cardiovascular function .

阿霉素对骨肉瘤（OS-732）及其耐药细胞（R-OS-732）钙离子通道的影响

Effect of doxorubicin on calcium channels of OS-732 and R-OS-732 cells

方法在原代培养的大鼠海马神经元上，应用膜片钳全细胞记录技术观察Ipt对钠、钾、钙离子通道电流的影响。

METHODS The effects of Ipt on sodium , calcium and potassium channels in cultured hippocampal neurons was observed using whole-cell recording technique .

钙离子通道阻滞剂（CCB）尼索地平和血管紧张素Ⅱ受体拮抗剂（ARB）奥美沙坦是临床上常用的降压药物。

Nisoldipine is a calcium channel blocker , and olmesartan is an angiotensin ⅱ receptor blocker ( ARB ) . Nisoldipine and olmesartan are both common anti-hypertensive drugs in clinic .

E3的促癌细胞增殖作用未见与经钙离子通道引起的非基因的快速调节作用有关，推测是基因调节作用的结果。

The effect of estriol on promoting the proliferation of cancer cells is not related to non-genic rapid regulation by calcium-iron channel ; it is supposed to be the result of gene-regulation .

至分娩前，血清中高水平的催产素（OT）与靶器官高表达的OTR结合后，通过与受体耦合的钙离子通道，促使胞浆内游离钙离子浓度升高。

Before delivery , the overtop levels of serum oxytocin ( OT ) bind to the OTR , which binding by the receptor-coupled calcium channels , elevating the free calcium concentration in cytoplasm .

目前已经证明Rb1能够阻滞心肌细胞钙离子通道，降低细胞内的钙浓度，对心肌缺血起到保护的作用。

At present , it is has been proved that Rb1 can constitute calcium channel in myocardial cell , degrade the concentration of intracellular Ca2 + and protect the animal pattern with myocardial ischemia and myocardial failure .

而且，雷米芬太尼既可通过刺激血管内皮细胞释放一氧化氮（NO）和前列环素（PGI2）来舒张血管，又可通过抑制电压敏感性钙离子通道来产生非内皮细胞依赖性血管舒张作用。

In addition , remifentanil was proved to produce vasorelaxation by both stimulating the release of nitric oxide ( NO ) and prostacyclin ( PGI2 ) from endothelial cells and suppressing the voltage-sensitive calcium channel independent of endothelial cells .

结论豚鼠耳蜗传出神经递质ACh通过兴奋N受体，开放OHC的细胞膜钙离子通道，使细胞外Ca2+内流外毛细胞内；[Ca2+]i增加需要细胞外液中钙离子存在。

Conclusion The data indicate that ACh , the neurotransmitter of efferent auditory nerve in cochlea , activates the nicotinic receptor to open the calcium channel in OHC membrane and increase [ Ca 2 + ] I of OHCs , which is extracellular Ca 2 + - dependent .

结论在急性应激反应中，CRH可直接作用于下丘脑神经元，开放膜L-型钙离子通道并促使钙离子内流，从而进一步激活内贮钙释放，使其[Ca2+]i明显增加。

Conclusions CRH has a direct effect on hypothalamic neurons , induces Ca 2 + influx via high voltage activated Ca 2 + channels , triggers Ca 2 + release from internal stores and as a result increases the [ Ca 2 + ] I level .

结论：①E3不引起胞内[Ca2+]i水平升高，E3促人结肠癌细胞增殖作用的机理符合甾体激素的基因调节作用，未见与钙离子通道的非基因的快速调节作用有关。

Conclusion : ① E 3 can not cause the intracellular [ Ca 2 + ] I increase . The effect mechanism of E 3 due to the effect of gene regulation , but not the effect of rapid non gene regulation by Ca 2 + cannel .

目的探讨中药钙离子通道拮抗剂人参皂甙单体Rb1对白血病多药耐药细胞系（K562/HHT）细胞内柔红霉素浓度的影响。MDR1阳性者骨髓细胞内柔红霉素浓度与阴性者相差显著。

Objective To explore the effects of saponins Rb1 on the intracellular concentration of DNR in human leukemic multi-drug resistant cell K562 / HHT in vitro . There was significant difference in the concentration of DNR between MDR 1 positive and MDR 1 negative cases before and after incubation .

不同钙离子通道阻滞对肾小球系膜细胞增殖的影响

The Effect of Different Calcium Channel Blocker on Glomerular Mesangial Cells Proliferation

依托咪酯对大脑皮质突触体钙离子通道亚型的作用

Effects of Etomidate on Calcium Channel Subtypes on Cerebrocortical Synaptosomes

庆大霉素对前庭毛细胞膜的钙离子通道可能有阻滞作用。

It is suggested that gentamicin can block the calcium channels of VHCs .

钙离子通道拮抗剂对颅脑撞击伤后神经元钙通道电流的影响

The Effect of Nimodipine on Calcium Current of Neurons after Brain Impact Injury

电压门控N-型钙离子通道是与神经元中释放的神经信号传递有关的跨细胞膜的特殊蛋白质分子。

N-type voltage-gated calcium channels are membrane-bound proteins involved in neurotransmitter release from neurons .

环维黄杨星D对心肌钙离子通道的作用

Effects of Cyclovirobuxine-D on Calcium Channels of Myocardium

其中康宁霉素Ⅵ具有在牛蛙心肌细胞膜上形成钙离子通道的性质。

Trichokonin ⅵ has the ability to form calcium channel on bullfrog cardiac myocyte membrane .

牛蛙球囊毛细胞钙离子通道

Calcium Channels in Bullfrog Saccular Hair Cells

其中，在影响心房电生理重构的过程中，不同的钠离子通道、钾离子通道和钙离子通道均表现出重构现象。

Meanwhile the ion channels of sodium , kalium and calcium ion are all remodeling .

钙离子通道拮抗剂应用较多。

Calcium antagonists used was the most .