配体结合

突变的多肽在GPⅠbα氨基端配体结合区发生构象改变。

The mutant polypeptide adopts an altered conformation in N terminal ligand binding region of GP ⅰ b α .

他们由不同的基因编码，氨基酸序列高度相似，特别是在DNA结合域和配体结合域。

They are encoded by separate genes , highly similar in amino acid sequences , particularly in the DNA binding domain and ligand binding domains .

不同种属动物肝细胞膜载脂蛋白CⅢ受体的放射性配体结合分析

Study of apo C ⅲ Receptors on Liver Plasma Membranes in Different Animal Species by Radioligand Binding Assay

N－糖链在纤连蛋白分泌及纤连蛋白受体与配体结合中的作用

The Role of N-Linked Oligosaccharides in the Secretion of Fibronectin and the Binding of Fibronectin Receptor with Ligand

方法放射配体结合分析法对IR的数目（用结合容量表示）与亲和力（用饱和常数表示）进行检测。

Methods The number and affinity of IR was detected by radioligand binding assay .

放射性受体-配体结合实验表明，咖啡酸和阿魏酸可竞争性地抑制ET1与其受体结合。结论咖啡酸和阿魏酸为新的非肽类ET1拮抗剂。

Conclusion Caffeic acid and ferulic acid are a new kind non-peptide ET antagonists .

Fas与其天然配体结合可引起表达Fas的细胞凋亡。

Fas can resulting in the apoptosis of fas-expressing cell by binding to its natural ligand .

放射性配体结合分析法测定鸡视网膜多巴胺D1受体

The Radioligand Binding Assay of Dopamine D1 Receptor in Chicken in vitro

为明确人体胃组织是否存在褪黑素受体（MR），应用放射配体结合法检测人体胃组织MR特异结合量。

To determine whether melatonin receptor s ( MR ) exist in human stomach , specific binding of melatonin receptor in human stomach was measured by radioligand binding assay .

结论受体N端的前3个LBR含有与配体结合的位点。

Conclusion The front 3 LBRs in N-end contain ligand binding sites .

LXRs由DNA结合域及配体结合域构成。

LXRs constitute with DNA - binding and ligand - binding domain .

EGFR同相应的配体结合形成同源或异源二聚体，从而激活细胞内下游信号传导通路。

Upon binding to corresponding ligands . the EGFR forms homo-or heterodimers and activate downstream signal transduction pathways .

金属铬络合染料废水中的铬Cr（Ⅲ）与偶氮类有机配体结合，呈络合状态，结构非常稳定。

Trivalent chromium existing in wastewater from the dye plants is in complex state and its structure is very stable when coordinated with organic azo compound ligands .

与配体结合后，ER发生构象变化并入核调控下游基因转录。

Upon ligand binding , ER undergoes conformational changes and translocates to nuclei where ER functions as a transcription factor to facilitate downstream gene transcription .

放射配体结合分析法检测子宫、脾脏雌激素受体（ER）水平；

The estrogen receptor ( ER ) levels of uterus and spleen were detected with method of radioligand binding assay of receptor ( REAR ) .

二价阳离子（Ca2＋、Mg2＋）有助于GBMB与配体结合。

The addition of divalent cations ( ca2 + , Mg2 + ) was beneficial to the ligand binding .

用体外放射性配体结合实验方法检测了梭曼对牛小脑γ-氨基丁酸（GABA）受体和GABA摄取的影响。

Effect of soman on ~ 3H-GABA binding to GABA receptor and GABA up-take of bovine cerebellum was studied in vitro .

方法应用放射配体结合分析检测了患者结肠mu、Kappa阿片受体含量变化。

Method The content of mu and kappa opiod receptors in colon were studied in radioligand binding assay ( RBA ) in STC .

其分子结构由4个功能区组成，分别是A/B区、DNA结合区域、铰链区和配体结合区域，每个区域都有其各自不同的功能。

The structural features of TRs include four functional domains : A / B domain , DNA-binding domain , hinge region and ligand-binding domain . Each domain has its respective function . Referring to the self-guard mechanism of G.

通过SDS-PAGE和westernblot检测纯化MBL的纯度及存在形式；同时应用配体结合实验鉴定MBL的活性。

The purified MBL purity and existing forms were detected by SDS-PAGE and Western blot . Ligand binding activity of the experimental identification of MBL biological activity .

目的通过生物信息学的多参数评估，综合分析人Toll样受体第9型（TLR9）的配体结合域。

Objective To predict binding domains of toll like receptor 9 ( TLR9 ) though multiply parameter analysis .

方法用放射免疫法和放射配体结合法测定25例MS患者的血浆皮质醇（F）含量和血白细胞GR含量。

Methods Radio - immunological method and radioligand combination were used to determine the contents of plasma cortisol ( F ) and the GR contents of blood corpuscles of 25 MS cases .

FCM能够良好地揭示FITCNGA同ASGPR之间的受配体结合特性。

FCM can display soundly the characteristic of the receptor ligand combination between ASGPR and FITC NGA .

利用酵母双杂交系统研究人血管内皮生长因子受体Flt-1的配体结合域

Study on Ligand Binding Domains of Human Vascular Endothelial Growth Factor Receptor Flt-1 by Yeast Two-Hybrid System

建立一种研究PDZ结构域配体结合特点的简单方法。

A simple method for characteristics of PDZ domain ligands was established .

PDB结构中结晶水分子在蛋白质与配体结合中作用的量子计算研究

QM / MM Study for the Function of Crystal Water in the Binding between HIV-1 Protease and Ligand

EGFR与配体结合后，受体酪氨酸激酶自磷酸化，激活包括RAS通路在内的下游信号通路，调控细胞增殖、分化。

Connection of EGFR and its ligand will result in autophosphorylation of receptor tyrosine kinase following by downstream pathways activation included RAS pathway to regulate proliferation and differentiation .

目的研究白细胞整合素CR3α亚基的Ⅰ结构域在配体结合中的作用。

Objective To investigate the role of ⅰ - domain in the ligand binding of CR3 ( CD11b ) .

在与配体结合或二聚化后，pIgR能够发生磷酸化。

It was believed that pIgR could phosphorate after ligand binding or dimeric .

对足月胎盘进行体外培养时，发现其表面的TLR-2或者TLR-4在与配体结合后能使胎盘产生IL-6和IL-8（19）。

Explants from term placenta have been shown to produce IL-6 and IL-8 following ligation of TLR-2 or TLR-4 ( 19 ) .