角膜溃疡

大扶康注射液联合二性霉素B治疗真菌性角膜溃疡

Use of fluconazole and amphotericin B to treat fungal corneal ulcer

Cu、Zn元素在细菌性角膜溃疡修复中的作用

Role of Copper and Zine Trace Elements in Bacterial Corneal Ulcer Recovery

配合两性霉素B氧气雾化治疗真菌性角膜溃疡的疗效观察

Efficacy of the sexes amphotericin B oxygen atomization treatment of fungal corneal ulceration

PCR检测在真菌性角膜溃疡中的诊断价值

Applied polymerase chain reaction detecting fungal corneal ulcer

方法：建立PCR检测标准铜绿假单胞菌方法，对兔铜绿假单胞菌感染性角膜溃疡模型研究并应用于临床，并与细菌培养做比较。

Methods : PCR was performed to detect the DNA segment of Pseudomonas aeruginosa .

细菌性角膜溃疡角膜组织中MMP-2、MMP-9表达的研究

Expression of MMP-2 and MMP-9 in bacterial corneal ulcer

目的探讨中国汉族人群蚕蚀性角膜溃疡与人类白细胞抗原（HLA）基因的相关性。

No significant association is found between HLA-DQ5 and Mooren 's ulcer in Chinese Han nationality .

目的探讨聚合酶链反应（PCR）快速检测在真菌性角膜溃疡诊断中的价值。

Objective To establish a method for rapid detection of clinical suspect fungal corneal ulcer by polymerase chain reaction ( PCR ) .

方法：将真菌性角膜溃疡患者30例分为氟康唑组（n＝16）和酮康唑组（n＝14），比较组间的治愈率和平均疗程。

Methods : 30 cases of fungal keratitis were divided into fluconazole group ( 16 cases ) and ketoconazole group ( 14 cases ) with corresponding drug used .

结论：IL-1α可能是角膜溃疡形成的原因之一。

Conclusion : The present result suggests that IL-1 α may be one of the factors of forming corneal ulceration .

目的研究SOD复合酶对兔细菌性角膜溃疡的保护作用及其作用机理。

Objective To observe the effect of superoxide dismutase ( SOD ) - compound on bacterial ulceration in rabbit 's eyes and explore its mechanism .

结论：MMP-2、MMP-9对细菌性角膜溃疡的发展可能起重要作用。

Conclusion : The MMP-2 and MMP-9 may play an important role in the course of the bacterial corneal ulcer .

国产双氯苯咪唑（Miconazole）治疗霉菌性角膜溃疡与内眼炎临床观察

Clinical Efficacy of Chinese Miconazole in Treatment of Fungal Keratitis and Endophthalmitis

60s组角膜溃疡率50%，穿孔率33.3%。

The rate of corneal ulceration and perforation was 50 % and 33.3 % respectively in Group 60s .

结论：EOW原液治疗家兔绿脓杆菌角膜溃疡有效。因而，其有可能成为治疗绿脓杆菌角膜溃疡的一种方法。

Conclusion : The EOW could be one treatment method for pseudomonas aeruginose cornea ulcer .

Mooren角膜溃疡免疫治疗学研究

Study on Immune Therapy of Mooren 's Corneal Ulcer

结论：5g·L－1FCZED治疗实验性烟曲霉菌角膜溃疡有效。

CONCLUSION : 5gL-1 FCZED appears to be effective in the treatment of A. fumigatus corneal ulcer .

中国汉族人群蚕蚀性角膜溃疡与HLA-Cw等位基因的相关性研究

Association of Mooren 's ulcer and HLA-Cw alleles in Chinese Han population

方法应用PCR技术对临床诊断活动期HSK33眼匐行性角膜溃疡5眼，原因不明角膜炎5眼进行HSV-1DNA检测。

Methods PCR was used to detect herpes simplex virus type 1 ( HSV 1 ) DNA in 33 eyes with active HSK , 5 eyes with serpiginous corneal ulcer and 5 eyes with keratitis with unknown cause .

其中MMP一2、一9分布最广，研究最多。在细菌性角膜溃疡和角膜烧伤中发挥重要作用。

MMP - 2 and - 9 are the widest members among MMPs and play an important role in the bacterial corneal ulcer and corneal thermal burn .

制作兔的细菌性角膜溃疡模型，测定针刺治疗后角膜组织中丙二醛（malondinaldehyde，MDA）含量和胶原酶活性。

Methods Content of malondinaldehyde ( MDA ) and activity of collagenase in corneal tissue of rabbits with bacterial corneal ulcer .

方法：取102例真菌性角膜炎患者的角膜溃疡标本，作KOH涂片镜检、真菌培养及菌种鉴定。

Methods : The corneal scrapings from 102 patients with fungal keratitis were subjected to 10 % KOH based smear before microscopic observation , fungal culture and strain identification .

结论使用PTK治疗药物治疗效果不佳的浅层角膜溃疡，能有效缩短治疗时间，并能获得较好的术后视力，治疗效果好而并发症较少。

Conclusion Using PTK to treat superficial fungal corneal ulcer could short cure time , make patients achieve better vision and has less complications .

结果活动期HSK具有上皮病变者30眼中24眼检出HSV-1DNA，5眼匐形性角膜溃疡全部未检出HSV-1DNA；

Results The results showed that 24 of 30 eyes with active HSK with epithelial lesions were positive for HSV 1 DNA . None of the five serpiginous corneal ulcers were positive .

结果10只眼在5～10d发生角膜溃疡，5只眼在7～12d发生角膜穿孔。

Results Corneal ulcer occured in 10 eyes 5 ~ 11 day later , and corneal perforation occurred in 5 eyes 7 ~ 12 days later .

目的：研究细菌性角膜溃疡患者角膜组织中的基质金属蛋白酶2、9（MMP2、9）的表达与分布，探讨其含量的变化与角膜病变的相关性。

Objective : To study the expression and distribution of the matrix metalloproteinase-2 and - 9 ( MMP-2 , - 9 ) in bacterial corneal ulcer .

感染后第14d及28d可见坏死性角膜炎及角膜溃疡形成，角膜基质中及浸润的炎性细胞中尤其是溃疡处可见MMP-2、-9及TIMP-1、-2表达显著增加。

Similar staining patterns were detected for TIMP-1 and TIMP-2 . Necrotizing keratitis with corneal ulceration was found on days 14 and 28 in p. i. This correlated with increased expression of MMP-2 and MMP-9 within the stroma and in infiltrating inflammatory cells .

方法对药物治疗无效的3例细菌性角膜溃疡，合并8.0～8.5mm直径的角膜溶解、穿孔；

Methods For 3 cases with bacterial corneal ulcer for whom drug treatment was useless , the rang of the corneal perforation and melting reached 8.0 ~ 8.5mm ;

其次为角膜溃疡穿孔伤占17.14%；

The second was corneal ulcer perforating injury ( 17.14 % );

30例蚕蚀性角膜溃疡病理形态与发病机理探讨

Patho-morphology and mechanism studies in 30 cases of corneal rodent ulcer