药物载体

脂质体（liposomes）是一种新型药物载体，具有生物相容性好、可生物降解、无毒和无免疫原性等优点。

Liposomes are novel drug carriers , as they have good biocompatibility , biodegradability , innocuity , non-immunogenicity .

采用可生物降解的聚合物作为药物载体，利用Fe3O4磁性纳米粒子的磁导向性来实现靶向给药的目的。

Biodegradable polymer and Fe_3O_4 nanoparticles were chose as drug carriers , and drug-loaded magnetic polymer microspheres can be delivered to the area of interest by an external magnetic field .

纳米粒技术（Nanoparticletechnology）是目前药物载体输送系统研究的热点之一。

Nanoparticle technology has been one of the focuses in drug carrier systems .

有望作为pH敏感口服结肠定位给药系统药物载体。

The results imply that SBCS could be potential pH sensitive carrier for colon-specific drug delivery system .

因此，低分子量壳聚糖（lowmolecularweightchitosan，LMWC）作为药物载体的研究开始被人们所关注。

So low-molecular-weight chitosan ( LMWC ) has become the focus of investigation .

同时对亲和乳胶微球在生化识别分离、DNA免疫诊断、药物载体等生物医药领域的应用作了介绍，并指出该领域的研究重点和发展前景。

The applications of microspheres to the areas of bio-separation , DNA diagnosis , drug carrier and so on are also introduced .

此外，选取合适的pH敏感高分子材料作为药物载体是设计和制备这种智能给药系统的另一关键。

Moreover , it is another key to choose a pH responsive polymer as drug carrier for this intelligent drug delivery system .

为了进一步提高纳米药物载体治疗肿瘤的效果，我们提出以双重pH响应性的纳米颗粒作为药物输送载体的概念。

To further improve the drug efficacy for cancer therapy , we propose the concept of tailor-made dual pH responsive nanoparticles as drug delivery carriers .

例如，在靶向给药系统（targetingdrugdeliverysystem，TDDS）中，就要求药物载体&凝胶微球的粒径小，而且要求其具有较好的单分散性。

For example , in the targeting drug delivery system ( TDDS ), some cases require small diameter and good monodispersity of microsphere drug carrier .

壳聚糖（CS）无毒，具有很好的生物相容性、生物可降解性，可作为一种新型药物载体。

Chitosan ( CS ) can be used as a new drug-carrier , for its in-toxicity , good biocompatibility and biodegradability .

多糖修饰的PLGA纳米粒作为抗肿瘤药物载体的研究

The Study of PLGA Nanospheres Surface Modified with Biotinylated Chitosan as the Antitumor Drug Delivery Carriers

所有这些特着都表明用所制备的PIC胶束作为新型智能药物载体是可行的。

All of theses features are quite feasible for utilizing it as a novel intelligent drug delivery system .

本研究目的在于合成作为潜在药物载体的星形多肽嵌段共聚物，并研究此聚合物装载药物模型及对pH敏感响应释放过程。

The research mainly aimed to synthesize a new type of star-block copolymers as a potential drug carrier , and to investigate its drug-loading capacity as well as the pH-responsive releasing property .

以聚乙二醇（PEG）、聚氨酯为载体的高分子由于具备上述优点而成为良好的药物载体。

Using polyethylene glycol ( PEG ) and polyurethane as the carrier of polymer with the above advantages to become a good drug carrier .

结论CMC作为抗癌药物载体，在卵巢癌介入治疗中具有较好的缓释性和安全性。

[ Conclusion ] CMC as an anticancer drug carrier had better delayed release capability and safety in the interventional treatment of ovarian carcinoma .

综述壳聚糖在生物大分子口服给药、pH敏感释药、靶向给药、纳米药物载体等药物制剂方面的应用研究进展。

Research advances in pharmaceutical preparations of chitosan were reviewed in this paper , including peroral macromolecular drugs delivery system , pH-sensitive drug release system , targeting drug delivery system , nano-drug carriers , and so on .

美国FDA允许将PLA作为控释药物载体，但其也存在亲水性较差，降解速率慢，降解周期难以调控等缺点。

FDA authenticated PLA as a control release drug delivery , still it has the disadvantages like poor hydrophilicity , low degradation rate , difficult to control the degradation cycle .

纳米Fe3O4颗粒是一种性能优异的纳米药物载体，蕴涵广阔的前景。

Nano-sized Fe_3O_4 is a novel type of nanometer drug carrier with excellent property . It has a broad foreground .

尺寸合适的SWNT能够通过内吞进入细胞内，具有药物载体的潜质。

As the ability to enter cell by endocytosis , SWNT with suitable size is potential drug carriers .

在一定的条件下对该药物载体材料进行了生理模拟液的浸泡实验，并用Fourier红外光谱和扫描电镜对其表面进行了表征分析。

The calcium phosphate glass ceramics were soaked in the simulated body fluid ( SBF ) under the certain condition and then the surface was characterized by Fourier transform infrared spectrometry ( FTIR ) and scanning electron microscope ( SEM ) .

结果表明：与PVP、PAA均聚物和物理混合物相比，PAA/PVP复合物作为药物载体能使萘普生具有肠溶包衣片的性质；

It shows that , compared with PVP , PAA homopolymers and physical mixtures , the complexes of PVP and PAA as drug carriers make naproxen have the property of enteric-coated pellets .

黄原胶（xanthangum），是分子量很大的一种多糖，因其无毒副作用和生物相容性而可应用作药物载体、进行控制药物释放，达到靶向定标的目的。

Xanthan gum is a kind of polysaccharide with high molecular weight ; it can be applied to the field of drug carrying and controlled drug releasing for targeted drug releasing because of its no-toxic and biological compatibility properties .

目的研究甲氨喋呤（Methotrexate，MTX）脐血与成人血红细胞载体的特性，初步探讨脐血红细胞药物载体的可行性，为红细胞载体的应用研究提供理论和实验依据。

Objective To study the characteristics of cord blood and adult blood erythrocytes as Methotrexate ( MTX ) delivery system , and explore the feasibility of cord blood erythrocytes as drug delivery , providing some theoretical and empirical evidence for its exploratory development .

结论：PNIPA-co-AA纳米水凝胶有望成为智能型控释和靶向性药物载体。

Conclusion : PNIPA-co-AA nano-hydrogels are promising candidates for novel drug carriers with advantages of controlled release and targeting effect .

ALG微胶囊为亲水性凝胶，其作为药物载体，包裹水溶性小分子药物，常发生泄漏，造成药物包封率较低，释放时间过短。

ALG microcapsule is a hydrophilic gel , as a drug carrier , it is easily leaked out encapsulated hydrophilic small molecular drugs , and cause a low encapsulate rate and a short releasing time .

结论纳米HAP在家兔无明显蓄积毒性，提示当用量远远小于最小致死剂量时，纳米HAP可作为药物载体，甚至在将来可能作为一种新型的抗癌药物，经静脉安全应用。

Conclusion Nano-hydroxyapatite has no accumulative toxicity to rabbits , it is suggested that it is safe when the hydroxyapatite-sol was applied intravenously as a drug carrier in small dosage more less than the medium lethal dose , even as a kind of anticancer drug .

目前，GNS及其衍生物在生物医药方面的研究和应用还处在探索阶段，如何根据实际需求对GNS/聚合物复合材料进行组织工程支架、药物载体等研究是极富挑战的工作。

But the application of GNS in biological medicine is still at the stage of exploration , it will be a challenge to conduct research of GNS / polymer composites for tissue engineering scaffolds and drug carrier to give full play to its excellent properties .

我们的研究表明HMSN可以作为药物载体，在血管内皮细胞内充分降解的同时，有可能较彻底地释放其装载的药物，加强药物对肿瘤细胞的毒性，从而抑制肿瘤细胞的增殖。

It is implicated that as drug carriers , HMSN could release the medicines loaded while it was degraded completely . It was also found that HMSN could enhance the cytotoxicity of drugs , inducing further more inhibition of cancer cells .

红细胞用作新型药物载体的研究进展

Research on Erythrocytes as A New Kind of Carriers for Drugs

难溶性抗肿瘤药物载体&嵌段共聚物胶束

Block copolymer micelles as delivery system for poorly soluble antineoplastic carrier