苯妥英

HPLC法同时测定人血清中卡马西平、环氧化卡马西平和苯妥英

HPLC Simultaneous Determination of Carbamazepine , Carbamazepine - 10 , 11 - epoxide , Phenytoin in Human Serum

RP-HPLC同时测定人血清中苯巴比妥、苯妥英、卡马西平的浓度

Determination of Phenobarbital , Phenytoin and Carbamazepine in Serum by RP-HPLC

方法：应用膜片钳单通道技术记录苯妥英对缺氧大鼠大脑皮质神经元上K（Ca）通道电流活动。

Methods : K ( Ca ) channal current was recorded with patch clamp technique in rat corticocerebral hypoxic neurons .

IGF-1经PI3K/Akt依赖性途径保护苯妥英诱导的小脑颗粒神经元凋亡

IGF-1 protection against cerebellar granule neurons apoptosis induced by diphenylhydantoin through a PI3K / Akt dependent pathway

目的：建立HPLC法同时测定血清苯妥英（PHT）与卡马西平（CBZ）浓度。

OBJECTIVE : To develop an HPLC method for quantitative determination of phenytoin and carbamazepine in blood serum .

服药前后比较，苯妥英锌使大鼠血清HDL－C和HDL－C／TC分别上升8%和17%（p＜0.05），（LDL＋VLDL）－C下降34%（p＜0.01）；

Phenytoin zinc could cause HDL-C and HDL-C / TC to increase by 8 % and 17 % . respectively ,( LDL + VLDL ) - C to decrease by 34 % ;

考察了大鼠口服苯妥英锌或苯妥英钠15mg／（kg·d）45d对血脂的影响。

Rats were treated with phenytoin zinc or phenytoin sodium 15mg / ( kg . d ) for 45d .

当癫疒间患者身高体重比增加或合并使用苯妥英时VPA动力学参数CL增加。

CL of VPA in epileptic patients will increase if ratio between body height and body weight of epileptic patients rises , or co-administrated with phenytoin .

报道了电极对苯巴比妥，硫喷妥，异戊巴比妥、苯妥英、利尿酸及水杨酸的电位响应特性及最佳pH与浓度区间。

The potentiometric response characteristics of the electrode with respect to thiopental , phenobarbital , amobarbital , phenytoin , ethacrynic acid and salicylate were studied and the optimum pH and concentration range of the electrode for different organic drugs were found .

背景与目的：探讨褪黑素（MT）对苯妥英（DPH）诱发小鼠的致畸效应的影响。

BACKGROUND & AIM : To test the hypothesis that antioxidant melatonin ( MT ) can reduce the incidence of phenytoin ( DPH ) induced teratogenesis .

P4502C9的底物包括甲苯磺丁脲、苯妥英、S法华令、氟西汀、洛沙坦等。

P4502C9 substrates mainly include tolbutamide , phenytoin , S-warfarin , fluoxetine , and losartan .

目的：探讨苯妥英（DPH）神经发育毒性与胚胎脑组织中自由基产生和氧化应激反应的关系。

AIM : To explore the relationship between the developmental neurotoxicity ( DNT ) induced by prenatal phenytoin ( DPH ) exposure and free radicals and oxidative stress initiated in the embryonic brain .

苯妥英锌腹腔注射的ED（50）和LD（50）分别为9.74和138.1mg/kg，治疗指数与苯妥英钠接近，刺激性比苯妥英钠小。

ED_ ( 50 ) and LD_ ( 50 ) of phenytoin zinc ip were 9.74 and 138.1 mg / kg respectively . The therapeutic index of phenytoin zinc was closed to that of phenytoin sodium , but its irritability was less than that of later .

成人癫痫苯妥英个体化治疗的临床意义

Clinical significance of phenytoin in the individual treatment of adult epilepsy

褪黑素对苯妥英诱发胚胎脑组织氧化性损伤的拮抗作用

Melatonin antagonizes the oxidative damage initiated by phenytoin in embryonic brain

苯妥英锌对家兔血清高密度脂蛋白胆固醇的影响

Effects of phenytoin zinc on serum high-density lipoprotein cholesterol in rabbits

幼年家兔口服苯妥英锌7个月小脑生长发育的研究

Development of cerebellum with 7 months orally phenytoin zinc in childhood rabbits

苯妥英锌对烧伤的临床治疗作用

Clinical observation of phenytoin zinc in the treatment of patients with burns

基因诊断在苯妥英治疗癫痫病中的应用

Application of gene diagnosis in treatment of phenytoin for epilepsy

苯妥英外用治疗难愈性创面疗效观察

Observation of the effect of topical phenytoin on intractable wounds

苯妥英锌抗脂质过氧化及对小鼠缺血心肌的保护作用

Anti-lipid peroxidation and protective effects of phenytoin zinc on mice ischemic myocardium

苯妥英锌抗实验性癫痫的研究

A Study of Antiepilepsy of Zinc Phenytoin in Experimental Epilepsy

经期性癫痫苯妥英血药浓度及药动学的周期性变化

Cyclical Variations of Blood Concentration of Phenytoin and Its Pharmacokinetics in Menstrual Epilepsy

苯妥英锌对癫痫小鼠脑内氨基酸含量的影响

Effects of zinc phenytoin on contents of amino-acids in brain of epileptic mice

苯妥英锌的制备及初步药理学研究

Preliminary studies on Preparation and pharmacology of zinc phenytoin

~（125）I-苯妥英放免分析测定盒的质量控制

The quality control of ~ ( 125 ) I - phenytoin RIA kit

苯妥英局部应用治疗痛风并发难治性溃疡3例

The Effect of Phenytoin on Refractory Ulcers in Gout

咖啡因对苯妥英诱导的小脑颗粒神经元凋亡的保护作用及机制

Protective effects of caffeine on apoptosis of cerebellar granule neurons induced by diphenylhydantoin

苯妥英-β环糊精包合物的生物利用度及溶解性能

Bioavailability and dissolution behaviour of the inclusion of phenytoin - β - cyclodextrin

癫痫病人血清与唾液中苯妥英浓度的测定及相关性研究

Monitoring the Concentration of Phenytoin in Serum , Saliva