膜转运

MDR产生原因复杂，膜转运相关耐药蛋白中P-糖蛋白（P-gp）的表达是最常见、最重要的原因。

It was caused by complicated reasons , among which the expression of the membrane transport - associated drug resistant protein , P - glycoprotein ( P - gp ) is the most common and important one .

基因敲除与基因突变动物模型在药物跨膜转运研究中的应用

Application of Gene Knockout and Gene Defect Models in the Study of Drug Membrane Transport

NAG11基因产物可能与ATP的跨膜转运有关。

And NAG 11 gene product may play a role in the transmembrane transport of ATP .

目的研究多巴胺突触前膜转运载体（Dopaminetransporter，DAT）的基因多态性与帕金森病（Parkinson'SDisease，PD）的关系。

Objective To detect the association between dopamine transporter gene polymorphism and Parkinson 's disease ( PD ) .

多肽Tat与CdTe量子点共价偶联后的跨膜转运

Intracellular Delivery of CdTe Quantum Dots Conjugated with Polypeptide Tat

P-糖蛋白是依赖ATP的膜转运蛋白之一，在肠、肝、肾脏等脏器均高度表达。

P-glycoprotein ( P-gp ), one of ATP-dependent membrane transporter , is highly expressed in intestine , liver and kidney .

目的观察异丙基肾上腺素（isoproterenol，Iso）导致的心肌肥大大鼠的心肌细胞牛磺酸（taurine，TAU）跨膜转运功能的改变。

AIM To observe myocardial taurine transport in the isoproterenol ( Iso ) induced rats .

14例健康对照者（对照组），取静脉抗凝血，分离纯化红细胞，分别测定血浆、红细胞牛磺酸浓度，并测定3H标记的牛磺酸跨红细胞膜转运。

Taurine content in plasma and erythrocytes and the kinetics of 3H taurine transport by erythrocyte were measured .

熊果酸在Caco-2细胞单层模型中的跨膜转运

Transport mechanism of Ursolic acid across Caco-2 monolayer model

蜕皮甾酮在Caco-2细胞模型中的摄取和跨膜转运研究

Transport and uptake of ecdysterone in Caco-2 cell monolayers

小肠上皮细胞计数、Na＋－K＋－ATPase活性和Na＋的跨膜转运的变化与小肠吸收Tyr的变化基本一致。

Paralled changes were found basically between small intestinal epithelial cell count , mucosal Na + - K + - ATPase activity and Tyr absorption .

目的：研究丹参素在Caco-2细胞模型中的跨膜转运机制。

Objective : To study the absorption mechanism of Danshensu by using Caco-2 monolayer model .

目前已知，肠腔内氨基酸的跨膜转运是由细胞膜上特殊的载体（transporter）来完成的。

As far as we know , the transport of luminal amino acid is accomplished by specific transporters in the plasma membrane .

结果表明，IHC－66的抗心律失常作用可能与其抑制Ca2＋、Na＋的跨膜转运有关。

Results indicate that the antiarrhythmic action of IHC-66 may be related to its inhibition on Ca2 + and Na + transmembrane influx .

TAT蛋白转导结构域介导的BCR/ABL融合蛋白在小鼠体内的跨膜转运

TAT protein transduction domain mediates transmembrane delivery of BCR / ABL fusion protein into tissue cells of mice in vivo

在分子生物学和细胞生物学的研究中，陆续发现了一系列短肽具有相似的跨膜转运功能，这类短肽被统称为蛋白转导域（proteintransductiondomains，PTDs）。

An array of short peptides have been found to have similar transmembrane transporting capability , and these peptides are collectively termed protein transduction domains ( PTDs ) .

方法采用体外培养的人小肠上皮细胞Caco-2模型对TMS的跨膜转运进行研究。

METHODS A human intestinal epithelial cell Caco-2 model in vitro was applied to study the transport characteristics of telmisartan .

ABC家族利用水解ATP的能量对溶质中多种生物分子进行跨膜转运，包括离子、氨基酸、磷脂、胆固醇和药物等。

ABC members transport various biomolecules , including ion , amino acids , carbohydrate , phospholipids and drug etc. across the cell membrane , using the energy derived from ATP hydrolysis .

结论：同在II型肌纤维中的作用一样，PDL也参与I型肌纤维中由胰岛素或肌肉收缩引起的肌细胞葡萄糖跨膜转运的信号转导系统。

Conclusion PLD is involved in the signal transduction processes triggered by insulin or contraction in glucose cross-membrance transportation in the type I muscle fiber , similarly as in type ⅱ fiber .

AQPs是负责水的快速跨膜转运的一个膜通道蛋白家族，在多种器官的液体平衡中起着重要作用。

AQPs is a family of membrane channel protein which facilitates rapid water transport across plasma membrane .

PC可以增加BA脂溶性，提高BA生物膜转运量，然而随着药脂比增加，BA-PC的吸收呈下降趋势。

The lipid solubility and biomembrane transport volume of BA could be increased by PC , but the absorption of BA-PC gradually descended with the increase of drug-phospholipid rate .

目的：研究磷脂酶D（phospholipaseD，PLD）是否参与胰岛素和收缩引起的I型肌纤维葡萄糖跨膜转运的信号转导体系。

Objective To investigate whether phospholipase D ( PLD ) is involved in the signal pathways of insulin - or contraction-induced glucose transport in the type I muscle fiber .

目的探讨离体培养钙化幼鼠心肌细胞牛磺酸（Tau）跨膜转运功能及牛磺酸转运体（TAUT）和半胱亚磺酸脱羧酶（CSD）mRNA含量的改变及意义。方法以β-磷酸甘油培养心肌细胞；

Objective To observe the alterations of taurine transport , taurine transporter ( TAUT ) and cysteine sulfinate decarboxylase ( CSD ) mRNA in the calcification of myocardial cells in vitro .

ATPase在离子的跨膜转运及膜电位的调节方面起着关键作用，主要分布在近端小管刷状缘，而在中间段腔面为弱阳性。

ATPase in the transmembrane transport of ions and the regulation of membrane potential plays a key role , mainly brush border of the proximal tubule , and in the intermediate segment though only weakly positive .

ZIP家族转运蛋白主要负责将Zn2+等二价阳离子跨膜转运进细胞内，以完成细胞内多种生理生化反应。

ZIP family ( ZRT / IRT-like proteins ) of zinc transporters is responsible for transporting Zn ~ ( 2 + ) into cells through cell membrane for completing many physiological and biochemical reactions .

本文数据提示arg-13在线粒体鸟氨酸过膜转运过程中起主要作用。

All available data suggest arg-13 plays a major role in mitochondrial ornithine transport .

目的观察不同剂量亚砷酸钠染毒大鼠肝细胞膜转运蛋白&多药耐药相关蛋白2（MultidrugResistance-AssociatedProtein2，MRP2）表达水平的变化及与砷代谢的关系。

Objective To explore the relationship between the expression of hepatic multidrug resistance-associated protein 2 ( MRP2 ) in rat correspondence with arsenite and arsenite metabolites .

通过利用细胞膜转运机制，rhomboid蛋白家族已经被证实用以调节蛋白水解。

By using the mechanism of cellular membrane trafficking , rhomboids have been evolved novel strategies to regulate the expression of proteolysis rhomboid family protein .

ABC转运蛋白（ATP-bindingcassettetransporter，ABCT）属于膜转运蛋白，存在于哺乳动物、细菌、真菌等多种细胞中，且与多种细胞的多药耐药（MultidrugResistance，MDR）有关。

ATP binding cassette transporter ( ABCT ), a membrane transporting protein existing in mammalian , bacterial , fungal and many other types of cells , is correlated with multidrug resistance in many cells .

多药耐药相关蛋白（MultidrugResistance-AssociatedProtein，MRP）是ATP结合盒膜转运蛋白超家族成员，在人脑胶质瘤中高表达，在胶质瘤的多药耐药机制中起重要作用。

Multidrug resistance-associated protein ( MRP ), which belongs to the families of the ATP-binding cassette ( ABC ) superfamily of transport proteins , is high expressed and involved in the multidrug resistance ( MDR ) in human gliomas .