羧基末端

LMP1羧基末端第三活性区对鼻咽上皮细胞生物学特性的影响

Biological Character of Nasopharyngeal Epithelial Cells Affected by Carboxy Terminal Activating Region-3 of the Epstein-Barr Virus Encoded Latent Membrane Protein 1

EB病毒潜伏膜蛋白LMP1编码基因沉默对NF-κB表达的影响LMP1羧基末端第三活性区对鼻咽上皮细胞生物学特性的影响

The Influence of LMP1 Silence on Expression of NF - κ B in EBV Positive Gastric Cancer Cells Biological Character of Nasopharyngeal Epithelial Cells Affected by Carboxy Terminal Activating Region-3 of the Epstein-Barr Virus Encoded Latent Membrane Protein 1

内皮抑素为胶原X羧基末端裂解片段，是重要的内源性血管抑制因子。

Endostatin , the C terminal proteolytic fragment of collagen X ⅷ, is a potent endogenous angiogenesis inhibitor .

目的探讨乙型肝炎病毒（HBV）表面抗原中蛋白羧基末端缺失突变体（MHBst）的反式激活功能。

Objective To investigate the transactivator function of the C terminal truncated middle surface protein of the hepatitis B virus .

PCR法检测正常组，肝阳上亢组，肝阳化风组泛素羧基末端水解酶的基因表达情况。

At the end of the experiment , PCR was used to evaluate the ubiquitin carboxy - terminal hydrolase LI expressions among these groups .

具有代表性的LMP1基因羧基末端PCR产物采用四色荧光终止序列技术进行DNA序列分析。

DNA sequencing of the representative PCR products of carboxyl-terminus of LMP1 gene was analyzed by using four-colored fluorescence terminator sequencing technique .

除位于羧基末端的跨膜区和胞质尾区外，F1亚单位的其余部分较保守（95.4%）；

Except the membrane anchor domain and the region of intra-cellular at the C-terminus F1 subunits , the rest of F1 subunits of the two hMPVs showed high sequence identity ( 95.4 % ) .

结果SED的空间结构与其它肠毒素超抗原相似，具有两个结构域：氨基末端结构域和羧基末端结构域。

Results The three dimensional structure of SED , similar to that of other enterotoxin superantigens , was composed of two domains : amino terminal domain and carboxyl terminal domain .

目的克隆艰难梭菌（Clostridiumdifficile，C.d）细胞毒素B羧基末端功能区（CDB3）基因，并对其进行测序及生物信息学分析。

Objective To clone the C-terminal domain gene ( CDB3 ) of Clostridium difficile ( C.d ) and to perform sequencing and analyse the biological information .

目的探讨泛素羧基末端水解酶L1（UCH-L1）基因的S18Y多态性在散发性阿尔茨海默病（AD）发病机制中的作用。

Objectives : To explore the role of S18Y polymorphism of Ubiquitin Carboxy-terminal Hydrolase-L1 ( UCH-L1 ) gene in the pathogenesis of sporadic Alzhermer 's disease ( AD ) .

血清羧基末端前胶原I型多肽和氨基末端前胶原III型多肽浓度：在黄芪皂甙IV剂量为10mg/kg和黄芪皂甙IV应用21d时恢复到对照组水平；

The serum concentration of carboxyterminal procollagen type I propeptide and aminoterminal procollagen type ⅲ propeptide returned to the level of control at a dose of 10 mg · kg-1 per day and at 21 days after astragaloside ⅳ administration , respectively .

同源域&亮氨酸拉链蛋白（HD-Zip）是高等植物中特有的一类转录因子，包含高度保守的同源异型域（HD），HD羧基末端与亮氨酸拉链域（LZ）紧密相连。

The homeodomain leucine zipper proteins ( HD-Zip ) are special transcription factors in higher plants . HD-Zip is characterized by a highly conserved homeodomain and a leucine-zipper domain linked closely to the C-terminal of the homeodomain .

EB病毒LMP1基因羧基末端在15例癌巢DNA样本中均可检测到，其中14例是30bp缺失型LMP1EB病毒株，1例是野生型和30bp缺失型LMP1株的混合感染。

The carboxyl-terminus of EBV LMP1 gene was detected in all 15 DNA samples of carcinoma nest , among which 14 were single 30-bp deleted LMP1 ( del-LMP1 ) EBV infection and 1 was coinfection of wild-type LMP1 ( wt-LMP1 ) EBV strain and del-LMP1 EBV strain .

目的：克隆并表达艰难梭菌毒素A羧基末端受体结合区（CDTAR）基因。

AIM : To obtain the high expression of the gene coding for clostridium difficile toxin A receptor binding zone ( CDTAR ) .

目的：探讨溶骨性骨代谢生化指标尿Ⅰ型胶原交联氨基末端肽（NTx）、血Ⅰ型胶原交联羧基末端肽（ICTP）定量检测诊断恶性肿瘤骨转移的价值。

Objective : To evaluate the benefits of using new bone metabolic markers such as urinary pyridinoline cross-linked N-telopeptides of Type I collagen ( NTx ) and serum pyridinoline cross-linked C-telopeptides of Type I collagen ( ICTP ) in the detection of bone metastasis in patients with malignant tumors .

它对裂开诸如酪氨酸这类氨基酸的羧基末端的侧肽链最为有效。

It is most efficient in clearing the peptide bonds on the C-terminal side of such amino acids tyrosine .

结果培养7~12d，I型前胶原羧基末端前肽含量和碱性磷酸酶活性最高；

Results The activity of ALP and the quantity of PICP reached the highest level when the osteoblasts had been cultured for 7 to 12 d.

尿氨基末端肽在转移性骨肿瘤诊断中的意义它对裂开诸如酪氨酸这类氨基酸的羧基末端的侧肽链最为有效。

Diagnostic value of urinary NTX in patients with bone metastasis It is most efficient in clearing the peptide bonds on the C-terminal side of such amino acids tyrosine .

结果与正常组与肝阳上亢组比较，肝阳化风组泛素羧基末端水解酶表达显著下降（P<0.01）。

Results As compared with the normal control group and the liver-yang hyperactivity group , UCH L1 decreased significantly ( P < 0.01 ) in the liver-yang forming wind group .

这些蛋白质具有共同的结构，即氨基端与分泌相关的信号肽，介导同源寡聚体形成的螺旋样结构域，和羧基末端介导配体活性的纤维蛋白原样结构域。

These proteins contain similar structures of a signal sequence ( related to secretion ) in amino terminus , a coiled coil quaternary structure ( mediated distinct homo oligomerization patterns ) and a fibrinogen like domain in C terminus ( which mediated ligand activity ) .