甘草次酸

甘草次酸是中药甘草的主要有效成分之一。

Glycyrrhetinic acid is a major active ingredient in licorice , a famous traditional Chinese medicine .

甘草次酸对苯并芘诱发DNA损伤及非程序DNA合成的影响

Effect of glycyrrhetinic acid DNA damage and unscheduled DNA

维生素C、氯化钴、乙双吗啉（AT（1727））及甘草次酸与阿霉素毒性关系的实验研究

A Study on the Influences of Vitamin C , Cobalt Chloride , Bimolane and Glycyrrhetinic Acid on the Toxicity Caused by Adriamycin

目的建立麻杏石甘汤中甘草次酸含量的HPLC测定方法。

Aim To establish an HPLC method for the determination of enoxolone in Maxing Shigan Decoction .

目的：探讨甘草次酸（GA）抑制K562细胞增殖的机制。

OBJECTIVE To study the mechanism of inhibition of K562 leukemia cells proliferation by glycyrrhetinic acid ( GA ) .

五环三萜类化合物&齐墩果酸（oleanolicacid）、18β-甘草次酸（18β-Glycyrrhetinicacid）和熊果酸（UrsolicAcid）广泛分布于植物界，显示出多种生物活性。

Oleanolic acid , 18 β - glycyrrhetinic acid and ursolic acid , as pentacyclic triterpenoids , are ubiquitous in the plant kingdom and exhibit various biological activities .

甘草次酸的去氧皮质酮（DOC）样作用分析

Studies on the mechanism of the Desoxycorticosterone ( doc ) - like actions of glycyrrhetinic acid in the rat

检测结果表明口服甘草次酸后血清中Na、Cu元素浓度与甘草次酸血药浓度变化趋势相同。

The test results showed that in rats after oral administration of glycyrrhetinic acid in serum Na and Cu concentrations of elements and the same trend of glycyrrhetinic acid plasma concentration .

有近几年研究表明甘草次酸具有抗心律失常、抗炎、抗免疫、镇痛、抗肿瘤、提高内耳听觉功能、抗HIV等作用。

In recent years , studies on Glycyrrhetinic acid pharmacology experiment such as anti-arrhythmic , anti-inflammatory and immune resistance , analgesic , anti-tumor , improving the inner ear hearing capabilities , anti-HIV effect .

目的：研究甘草次酸（Gta）的抗心律失常作用。

Objective : To investigate the antiarrhythmic effect of glycyrrhetinic acid ( Gta ) .

Box-Behnken效应面法优化甘草次酸长循环脂质体的处方

Formulation optimization of long-circulating liposomes entrapped with glycyrrhetic acid by Box-Behnken design and response surface methodology

甘草次酸钠腹腔给药对小鼠S180、HepS具有不同程度的抑制作用，在10mg/kg时，抑制率分别为53.13%和40.10%（P值<0.05）。

The inhibition rates of GC-Na , ip 10 mg / kg × 10d for S_ ( 180 ) and Hep in mice were 53.13 % ( P < 0.05 ) and 40.10 % ( P < 0.05 ) .

响应面设计法优化单葡萄糖醛酸基甘草次酸（GAMG）发酵转化培养基

Optimization of medium composition for glycyrrhetinic acid monoglucuronide ( GAMG ) production using response surface methodology

目的：探讨全反式维甲酸、18β-甘草次酸和甘草酸对BEL-7402人原发性肝癌细胞诱导分化和凋亡的作用。

Objective : To investigate the effects of all-trans retinoic acid , 18 β - glycyrrhetinic acid and glycyrrhizin on the induction of differentiation and apoptosis of BEL-7402 human primary hepatocarcinoma cells .

甘草次酸（Glycyrrhetinicacid，GA）为中药甘草的主要活性成分，具有明显的抗炎、抗菌、抗病毒、保护肝细胞与免疫调节等多方面的药理活性，对于局部炎症如静脉炎有较好效果。

The main active ingredient of traditional Chinese medicine licorice , Glycyrrhetinic acid has significant anti-inflammatory , antibacterial , antiviral , protect liver cells and immune regulation , and other aspects of pharmacological activity [ 1-3 ] , for local inflammation , such as phlebitis have better results .

方法：以甘草次酸、肉桂酸、总黄酮、挥发油、干浸膏的含量为指标，用均匀设计优选出桂枝甘草汤方药的SBE法最佳工艺条件；

Methods : At first , optimizing the SBE technical conditions for Guizhi Gancao Decoction ingredients through even design while Glycyrrhetinic Acid , Cinnamic Acid , total flavones , volatile oil and dry extract were adopted as indexes ;

[目的]观察甘草次酸（GA）对胶原诱导性关节炎大鼠滑膜成纤维样细胞（CIA-FLS）TNF-α、IL-1β表达的影响，并尝试与传统治疗药物MTX联合应用进行研究。

[ Aims ] To observe the features of fibroblast-like synovial cells from collagen induced arthritis in rats ( CIA-FLS ), and determine the effects of glycyrrhetinic acid ( GA ) on CIA-FLS cell TNF alpha and interleukin-1 β expression in vitro . [ Methods ] 1 .

目的：观察18β-甘草次酸钠（β-SG）对体外培养的小鼠腹腔巨噬细胞摄取氧化型低密度脂蛋白（oxLDL）的影响，并探讨其可能的作用机制。

OBJECTIVE : To study the effect of 18 β - sodium glycyrrhetate (β - SG ) on the uptake of oxidized low density lipoprotein ( oxLDL ) in peritoneal macrophages of mice cultured in vitro and to study its possible mechanism .

甘草次酸涂丝电极的研制铂复合电极研究进展

Research on the Making of Platinum Wire Electrode Covering Glycyrrhetinic Acid

但以含2.0%氮酮的甘草次酸钠贴剂，其透皮吸收为最好。

The best one was the plaster containing 2.0 % azone .

丹皮酚和甘草次酸溶度参数不同测定方法的比较

Comparison of Different Determination Methods for Solubility Parameters of Paeonol and Glycyrrhetinic

甘草次酸是重要的医药中间体，具有广泛的用途和应用前景。

Glycyrrhetic acid is an important drug intermediate with wide application prospect .

壳聚糖/甘草次酸温敏凝胶的制备及性能研究

Synthesis and properties of chitosan / glycyrrhetinic acid thermo-sensitive hydrogel

肝细胞靶向甘草次酸表面修饰脂质体的制备

Preparation of Liposomes Surface-modified with Glycyrrhetinic Acid Targeting to Hepatocytes

氮酮对甘草次酸钠透皮吸收的影响

Effect of azone on the transdermal absorption of sodium glycyrrhetinic acid plaster

甘草次酸与血清白蛋白的结合与其药理意义

Binding of Glycyrrhetinic acid to bovine serum albumin and its pharmacological significance

聚乙二醇改性甘草次酸/5-氟尿嘧啶复合物的制备与生物活性研究

Preparation and bioactivity of glycyrrhetinic acid-polyethylene glycol / 5-fluorouracil complexes

甘草次酸3位酯类衍生物的合成及其抗炎活性的研究

Synthesis and anti-inflammatory activity of 3-esterified derivatives of glycyrrhetinic acid

离体鼠肝细胞膜上甘草次酸和甘草酸受体的表达

Respective of the receptors for glycyrrhetinic and for glycyrrhizin on isolated hepatocyte membranes

甘草次酸与大鼠肝膜血管紧张素Ⅱ受体相结合

Binding of glycyrrhetinic acid to the angiotensin ⅱ receptor in rat liver membrane