熊去氧胆酸

目的评价熊去氧胆酸（ursodeoxycholicacid，UDCA，商品名优思弗）治疗慢性肝炎重度伴胆汁淤积的疗效及安全性。

Objective To evaluate the efficacy and safety of ursodeoxycholic acid ( UDCA ) in the treatment of severe chronic hepatitis with cholestasis .

熊去氧胆酸和维甲酸对人成骨肉瘤细胞MG-63细胞周期与分化的影响

Effects of Ursodeoxycholic Acid and Retinoic Acid on the Cell Cycle and Differentiation of Human Osteosarcoma MG-63 Cells

HPLC法测定人工引流熊胆汁中熊去氧胆酸含量

HPLC Determination of BHe Acid in Living Bear Bile

RP-HPLC直接测定普济痔疮栓中牛磺熊去氧胆酸含量

Determination of Tauroursodeoxycholic Acid in Puji Suppository for Hemorrhoids by RP-HPLC

地塞米松与熊去氧胆酸能有效改善ICP症状及肝功能。

Dexamethasone and DUCA could improve the symptoms and liver functions effectively .

目的建立HPLC测定普济痔疮栓中牛磺熊去氧胆酸含量的方法。

Objective To establish a HPLC method for the determination of tauroursodeoxycholic acid ( TUDCA ) in Puji Suppository for hemorrhoids .

Guo表示：熊去氧胆酸是熊胆汁40多种成分中的一种。

Gao said : Urso is one of the more than 40 elements in bear bile .

目的：探讨熊去氧胆酸（UDCA）对胆肠吻合术后胆道逆行性感染的预防作用。

ObjectiveTo investigate the effect of ursodeoxycholic acid ( UDCA ) on prevention of retrograde biliary tract infection after cholangioenterostomy .

目的探讨熊去氧胆酸（ursodeoxycholicacid，UDCA）的应用对胆汁淤积症（ICP）孕鼠脏层卵黄囊细胞膜脂质流动性及胎盘组织谷光甘肽（glutathione，GSH）含量的影响。

Objective To explore the effects of ursodeoxycholic acid ( UDCA ) on the fluidity of rat visceral sac and placental glutathione ( GSH ) concentration in rats with intrahepatic cholestasis .

熊去氧胆酸（UDCA）是惟一经随机对照临床试验证实的治疗PBC安全有效的药物。

Ursodeoxycholic acid ( UDCA ) is the only safe and effective drug for the treatment of PBC proven by randomized controlled clinical trials .

方法：以16例PBC患者为观察对象，采用熊去氧胆酸（每日13-15mg/kg体重）和中药止痒方、软坚散、消黄散等中西医结合方法治疗。

METHODS : 16 PBC patients were observed . Ursodeoxycholic Acid ( UDCA ) was used 13 to 15 mg / kg / day , with some Chinese herbal prescription .

熊去氧胆酸（UDCA）的作用以及能预测获得这种TIW后免疫耐受的患者特征尚不清楚。

The role of ursodeoxycholic acid ( UDCA ) and patient characteristics that predict the success of this tolerance are unclear .

建立了HPLC-ELSD法测定熊胆粉提取物中的熊去氧胆酸和鹅去氧胆酸。

An HPLC-ELSD method was established for the determination of ursodeoxycholic acid and chenodeoxycholic acid in the extract of bear biliary drainage powder .

结论PBC肝损害以胆汁淤积为主，抗线粒体抗体M2阳性对PBC诊断有较高特异性，熊去氧胆酸为治疗首选；PBC常伴发SS，二者密切关联又有明显不同。

Conclusions PBC manifests with predominant cholestatic liver involvement and often associates and complicates with SS ; For PBC , AMA-M2 is a specific antibody and ursodeoxycholic acid should be the first choice for the treatment .

熊去氧胆酸（UDCA）是美国食品和药品管理局（FDA）批准的治疗PBC的唯一有效药物，但UDCA能否可以显著延长病人生存期及对肝移植的需求尚有不同的观点。

UDCA is the U.S. FDA-approved treatment PBC only effective drugs , but UDCA could significantly prolong the survival period and the demand for liver transplantation there are different points of view .

目的从胆石症病人胆汁中分离、提纯氨肽酶N（AminopeptidaseN，APN），观察其成核活性，并探讨熊去氧胆酸对APN的影响。

Objective [ WT5BZ ] Aminopeptidase N ( APN ) was purified from the bile of patients with gallstones and its nucleation effect was studied in order to evaluate the effect of ursodeoxycholic acid ( UDCA ) on APN .

目的观察胆固醇结石病人和无结石者之间胆囊胆汁中氨肽酶N（APN）活性的变化及熊去氧胆酸（UDCA）对APN活性的影响。

Objective To observe the difference of aminopeptidase N ( APN ) activity in gallbladder bile between patients with cholesterol gallstones and those without them and the effect of ursodeoxycholic acid ( UDCA ) on APN activity .

熊去氧胆酸片对肝功能指标的改善以谷丙转氨酶、t-PA显著（P<0.01），HOMA-IR、Ins、PAI-1及症状亦有所改善。

The improvement in liver function related indexes in the control group was mainly the level of ALT , t-PA ( P < 0.01 ), and also shown on HOMA-IR , Ins and PAI-1.Conclusion RPM could effectively improve liver function and fibrinolytic status .

目的研究大鼠禁食状态下不同起源的胃肠移行性复合肌电活动（MMC）的特征异同以及胃动素（MTL）和熊去氧胆酸（UDCA）对不同起源MMC的作用。

Objective To investigate the different characteristics of gastrointestinal migrating myoelectrical complex ( MMC ) of different origin in fasting state and the effects of motilin ( MTL ) and ursodeoxycholic acid ( UDCA ) on the MMC of the gastrointestinal tract of different origin in rats .

由于熊去氧胆酸（UDCA）可通过免疫调节、增加内源性胆汁酸的分泌和保护肝细胞膜等机制而发挥其改善患者肝功能和延缓疾病进程的作用，对于早期病变有一定的疗效。

As ursodeoxycholic acid ( UDCA ) can improver liver function of patients and delay disease progression by regulating the immune 、 increasing secretion of endogenous bile acid 、 protect the liver cell membrane and other mechanism . It have a certain effect in early lesions of the disease .

熊去氧胆酸对抗乙炔雌二醇诱发孕大鼠肝内胆汁淤积

Ursodesoxycholic Acid Prevent Intrahepatic Cholestasis Induced by Ethinylestradiol in Pregnant Rats

熊去氧胆酸治疗妊娠瘙痒症的临床观察

The clinical trial on pruritis of pregnancy treated with ursodeoxycholic acid

高效液相色谱法测定熊胆粉中牛磺熊去氧胆酸含量

Assaying of tauroursodeoxycholic acid in bear biliary drainage powder by HPLC

胆宁片、胆通、熊去氧胆酸治疗慢性胆道感染、胆石病的临床疗效对照研究

Treatment of Chronic Biliary Tract Infection and Gallstone Diseases with Dan Ning

丁二磺酸腺苷蛋氨酸联合熊去氧胆酸治疗妊娠肝内胆汁淤积综合征临床效果分析

Analysis of combination of transmetil with ursodesoxycholic acid treating intrahepatic cholestasis of pregnancy

熊去氧胆酸治疗慢性肝病的多中心临床研究

Multicenter study of ursodeoxycholic acid ( Ursofalk ) in treatment of chronic hepatitis

熊去氧胆酸治疗慢性肝炎重度伴胆汁淤积的多中心研究

Multicenter study of ursodeoxycholic acid on patients of severe chronic hepatitis with cholestasis

熊去氧胆酸辅助预防肝移植排斥的临床研究

Clinical research of ursodeoxycholic acid as adjuvant treatment to prevent liver transplant rejection

熊去氧胆酸治疗慢性重型肝炎的疗效观察

Efficacy of Ursodeoxycholic Acid on Chronic Severe Hepatitis

将它们水解后层析，只有熊胆汁含游离的熊去氧胆酸。

After hydrolysis , only bear bile contains free ursodeoxycholic acid revealed by chromatography .