活性位点

谷胱甘肽过氧化物酶（GSH-Px）的活性位点含有硒半胱氨酸残基。

The active site of the potent glutathione peroxidase ( GSH-Px ) contains selenocysteine residues .

三维结构显示，该抑制剂专一地结合于RG的活性位点，占据RG的底物结合部位，为竞争性抑制机制提供了结构依据。

This inhibitor anchors exclusively in the active site of RG by competition with its natural substrate , providing structural evidence for a competitive inhibition mechanism .

使用bindingsite模块对蛋白的活性位点进行分析。

Protein active sites were analyzed by the Binding Site module .

新城疫病毒F蛋白细胞融合活性位点中保守氨基酸基因突变分析

Mutational Analysis of Conserved Amino Acids on the Active Domain of Newcastle Disease Virus Fusion Protein

HIV-1整合酶四聚体结构模拟及其活性位点分析

Modeling the Tetrameric Structure and Its Active Sites of HIV-1 Integrase

在motifB中，存在一个高度保守的组氨酸残基，被认为是MBOAT家族中一个可能的活性位点残基。

In motif B , we found a highly conserved histine residue , which is suggested to be a putative active-site residue .

因此推测：Ce3+在SOD酶中创造了一个新形式的金属离子活性位点，从而影响SOD酶的活性。

It implied that the Ce3 + coordination created a new metal ion-active site form in SOD , thus leading to an enhancement in SOD activity .

序列分析表明，林麝IL-2及其受体结合域与水牛的高度保守，而在翻译后修饰的预测活性位点上和水牛的有所不同。

Sequence analysis of IL-2 showed that it had high homology with that of bubalus bubalis , except the difference of post-translational modification .

结论：获得的序列H×A××××××P××为设计肿瘤逃逸相关的CD59活性位点的短肽封条提供了技术基础。

CONCLUSION : The obtained sequence H × A ×××××× P ×× is helpful for design of short-peptide clamp of active sites of CD59 related to tumor escape .

前列腺细胞高表达的CD59分子活性位点的封闭研究

Blockade of the activity site of CD59 molecules highly expressed on prostate cancer cells

聚合酶链反应诱导丙型肝炎病毒（HCV）蛋白酶活性位点的突变及突变HCVNS3/4a蛋白的表达

Inactivation of hepatitis C virus ( HCV ) nonstructural ( NS ) 3 serine protease by PCR-mutagenesis and expression of mutant HCV NS3 / 4a

模体搜索结果表明在PK上具有多种N-糖基化位点、蛋白激酶C磷酸化位点、丙酮酸激酶活性位点等多个功能结构域。

Motif search results indicate that there are a variety of N-glycosylation sites , protein kinase C phosphorylation sites , pyruvate kinase active sites and other functional domains on PK .

结果表明N端的类似锌指蛋白的结构不是结合核酸的活性位点，部分缺失C端的碱性氨基酸也不影响其结合。

Our results suggest that the putative zinc finger motif in the N-terminal is not essential to the binding and that partial deletions of the basic regions in the C-terminal also cannot prevent the proteins from binding nuclear acids .

survivin序列包含三个PKC活性位点、两个酪氨酸蛋白激酶位点和一个PKA位点。

The sequence of survivin include three phosphoric sites of PKC , two phosphoric sites of Tyr kinase and one phosphoric site of PKA .

Rudolph起初知道激酶和磷酸酶总拓朴图以及活性位点的位置。

Rudolph initially knew the kinase 's and phosphatase 's general topographies as well as the locations of their active sites .

预测ADH包含一个醛-酮还原酶超家族的保守结构域，该结构域有25个活性位点，4个催化亚单位。

Predictive analysis showed that ADH contained a conservative domain of aldo-keto reductase superfamily . It contained 25 active sites and 4 catalytic tetrads .

只有当活性位点与热点正确契合时，这种短暂的对接才能实现其在细胞分裂周期中的作用，Rudolph说。

Only when active sites and hot spots fit correctly can this brief docking accomplish its role in the cell division cycle , said Rudolph .

同时，辣根过氧化物酶（HRP）代替牛血清白蛋白（BSA）被用来阻止可能残留的活性位点和避免非特异性吸附。

In the meanwhile , horseradish peroxidase ( HRP ) instead of bovine serum albumin ( BSA ) was employed to block the possible remaining active sites and avoid the nonspecific adsorption .

FDA在2000年批准了一种新的直接凝血酶抑制剂比伐卢定应用于临床，该药是水蛭素的类似物，它通过抑制凝血酶的活性位点而起效。

Bivalirudin , as a new direct inhibitor of thrombin , was approved by US Food and Drug Administration in 2000 . It is an analogue of hirudin that can inhibit the active site of thrombin .

他们也设计了一个特殊的抑制物（小分子），它可以结合在人类DDAH的活性位点上。

They also designed specific inhibitors ( small molecules ) which bind to the active site of human DDAH .

同时，我们对猪胰蛋白酶进行了纯化并做了一系列的对照实验，验证了猪胰蛋白酶催化的aldol反应确实发生在其活性位点上。

Meanwhile , we purified the trypsin and performed some control experiments . The results indicated that the trypsin-catalyzed aldol reaction took place in the native active site .

首先考察蛋白质二硫键异构酶（PDI）和DsbA的结构特性，发现其活性位点周围具有疏水性表面。

Firstly , structural characteristic of protein disulfide isomerase ( PDI ) and DsbA were investigated . Hydrophobic regions were observed around their active sites .

结论获得了与高表达人CD59的CHO细胞结合的内化短肽序列，为进一步设计与肿瘤逃逸相关的CD59活性位点的短肽药物提供了参考依据。

Conclusion This study might provide the reference for the design of a drug similar to the short peptide of CD59 on tumor sneaking through by obtaining the sequence of the internation peptide .

虽然Trx具有多种生理功能，但其最基本的功能是通过其活性位点（Cys-Gly-Pro-Cys）调节体内氧化还原平衡及抗氧化损伤。

Although Trx has many biologic functions , its fundamental functions are regulating biologic redox equilibrium and preventing against oxidant injuries through its active site Cys-Gly-Pro-Cys .

硫氧还蛋白（Thioredoxin，TRX）是广泛存在于原核和真核细胞中的低分子量蛋白质，它含有保守的CysGlyProCys活性位点，作为多效性细胞因子而具有重要的生物学功能。

Thioredoxin ( TRX ) is a low molecular weight protein found in both prokaryotic and eukaryotic cells and has a conserved Cys Gly Pro Cys active site .. It plays an important biological role as a multifunctional protein .

经生物信息学分析，LC-ALDH具有醛脱氢酶基因家族绝对保守的谷氨酸活性位点、半胱氨酸残基和组氨酸残基。

LC-ALDH has an absolute conservative glutamic acid active site , cysteine residue and histidine residue of aldehyde dehydrogenase by bioinformatics analysis .

预测PGM1包含四个结构域；共有14个活性位点，4个金属离子结合位点，14个底物结合位点，9个二聚体结合位点。

Predicted that PGM1 contained four domains and a total of 14 active sites , 4 metal binding sites , 14 substrate binding sites , 9 dimer interfaces .

所编码的蛋白具多聚半乳糖醛酸酶的保守序列和蛋白活性位点（NNYCSGGHGISIGS），其蛋白结构也具明显的相似性。

The predicted proteins had a typical PG consensus fragment and protein active site ( NNYCSGGHGISIGS ), and had a similar tertiary structure .

通过对比分析结果显示，成熟的蛋白与其它蜜蜂的PLA2一样，含有10个半Bi-PLA2胱氨酸残基并且有高度保守的Ca2+结合位点和活性位点。

Comparative analysis revealed that the mature Bi-PLA2 ( 136 amino acids ) possesses features consistent with other bee PLA2S , including ten conserved cysteine residues , as well as a highly conserved Ca2 + - binding site and active site .

第一类和第二类的不同在于150-loop（残基147-152）活性位点附近是否有一个大的空腔。

Based on the crystal structures , the difference of two groups is that the first group has a large cavity close to the active site on the 150-loop , at residues 147-152 .