氮芥

氮芥所致DNA损伤分子标志物探讨

Study on molecular biomarker of DNA lesion induced by nitrogen mustard

生长抑制和DNA损伤基因表达对氮芥所致DNA损伤的监视作用

The Effect of Gadd Genes Expression in Surveillance of DNA Damage Induced by Nitrogen Mustard

荧光法研究苯甲酸氮芥铕配合物与DNA的相互作用

Study on the interaction between DNA and the complex of benzoic acid nitrogen mustard with Eu (ⅲ) by the fluorescence method

Co（III）氮芥配合物的合成、表征及其抗肿瘤活性的初步评价

Synthesize and characterization of Co ( III ) mustard complexes ( HSAs ) and cytotoxicity in vitro

考虑到疏水药物苯丁酸氮芥的靶标是DNA链，经苯丁酸氮芥修饰的阳离子聚合物既有利于基因转染，又可以增强药效。

Considering that the target of hydrophobic chlorambucil is DNA strands , the hyperbranched polycations are modified with chlorambucil for both gene transfection and drug delivery .

肿瘤的化学治疗ⅩⅢ.几种带氮芥基的Schiff碱

Tumour chemotherapy ⅹⅲ . some schiff 's bases containing the nitrogen mustard grouping

甲基苯丙氨酸氮芥（AT（1420））对艾氏腹水癌细胞的杀伤动力学及对HeLa细胞DNA合成的抑制

The effects of methylmerphalan ( at-1420 ) on the cytokinetics of Ehrlich ascitic tumor cells and on the DNA synthesis of HeLa cells

研究表明：氮芥和哌嗪衍生物卟啉能与BSA形成稳定配合物，其结合数都约为1。

Research results showed that porphyrins could bind to BSA to form steady complexes by hydrophobic force .

前言：目的：研究盐酸氮芥、氮芥异构体对K（562）及L（1210）细胞增殖的影响。

Objective : To study the effects of mustine and its isomeride on K562 and L1210 cell lines .

结论Gadd基因表达能够监视氮芥所致的DNA损伤。

Conclusion Gadd genes expression can be used as the indexes in the surveillance of DNA damage induced by nitrogen mustard .

PUVA联合α-干扰素及氮芥外用治疗斑块期蕈样肉芽肿1例

A Case of Granuloma Fungoides Treated with PUVA and Inteferon - α and Nitrogen Mustard

采用紫外可见光谱滴定法测定了β环糊精（βCD）在10℃，不同pH值条件下包合苯丁酸氮芥（CHL）的稳定常数，探索了主客体分子间的作用机理。

UV-vis spectrophotometric titration was used to calculate the stability constants of an inclusion complex of β - cyclodextrins (β - CD ) with chlorambucil ( CHL ) in different pH buffer solutions at 10 ℃ .

~（125）I-C（60）吡咯烷苯氮芥的制备和生物分布

Preparation and bio-distribution of ~ ( 125 ) I-fullerene pyrrolidine benzoyl nitrogen mustard

目的探索苯丁酸氮芥（CHB）和环磷酰胺（CP）在体外是否通过烷化激活大鼠肝微粒体谷胱甘肽S-转移酶（mGST）。

AIM To study whether chlorambucil ( CHB ) and cyclophosphamide ( CP ) activate rat liver microsomal glutathione S-transferase ( mGST ) by alkylation .

目的：研究叶下珠植物（PU）提取物对盐酸氮芥（NH2）损伤睾丸生精上皮细胞骨架中间丝波形蛋白的保护作用。

Objective : To explore the protective effect of Phyllanthus urinaria ( PU ) extraction on cytoskeleton vimentin disrupted by nitrogen mustard ( NH2 ) in spermatogenic epithelium in vivo .

结论氮芥治疗银屑病的机制可能与IL1α、IL6和IL8有关。

Conclusion These results suggested that the mechanism of Mechlorethamine therapy on psoriasis is related to IL-1 α, IL-6 and IL-8 .

AT-1420即甲基苯丙氨酸氮芥。

AT-1420 is methylphenylalanine mustard .

患者，男，41岁，MF肿瘤期（Ⅲ期），采用氮芥溶液外用及泼尼松（40mg/d）口服联合治疗，治疗35天，除额部皮损轻度浸润外，其它皮损全部变平。

A 41 - year - old man , with diagnosis of granuloma fungoides (ⅲ stage ) was treated with oral predisone ( 40mg / d ) and topical nitrogen mustard therapy for 35 days , most of skin eruption became flat .

目的：研究叶下珠（PU）提取物对盐酸氮芥（HN2）损伤睾丸组织N-钙粘蛋白表达的保护作用。

Objective : To explore the protective effect of the Phyllanthus Urinaria ( PU ) extract on the N-cadherin expression in the testicular tissues disrupted by nitrogen mustard ( HN2 ) in vivo .

单克隆抗体&苯丁酸氮芥靶向治癌偶联物的研究

Studies on the Targeted Monoclonal Antibody-Chlorambucil Conjugate for the Treatment of Cancer

脂质体包裹的氮芥对家兔急性实验性血清病的影响

Effects of Liposome-encapsulated Nitrogen Mustard on Acute Experimental Serum Sickness in Rabbits

外用氮芥酊后出现多发性樱桃状血管瘤

A case of multiple cherry angiomas after topical nitrogen mustard

盐酸氮芥及其异构体抗肿瘤研究

An Experimental Study of Mustine and Its Isomeride on Tumor

口服泼尼松联合氮芥溶液外用治疗蕈样肉芽肿肿瘤期1例

A case of granuloma fungoides treated with oral prednisone and topical nitrogen mustard

甲基苯丙氨酸氮芥（AT&1420）的毒性研究

A study on the toxicity of anticancer drag at-1420

肿瘤的化学治疗Ⅸ.磷酰胺及磷酸酯类氮芥的合成

Tumour chemotherapy ⅸ . nitrogen mustards of phosphoramide , phosphoramide ester and thioester

几种氮芥类抗肿瘤药与大鼠血浆的结合

The Physical Binding of Several Phenylalanine Derivatives of Nitrogen Mustard with Rat Plasma

苯丁酸氮芥及环磷酰胺对大鼠肝微粒体谷胱甘肽S-转移酶的激活

Activation of rat liver microsomal glutathione S-transferase by chlorambucil and cyclophosphamide in vitro

N-氮芥苯甲酰基-D-葡萄糖胺的合成

Synthesis of N - nitrogen mustard benzoic-glucosamine conjugate

长链醇和胺修饰的芳香氮芥衍生物的合成及生理活性

Synthesis and Biological Activity of Aryl Nitrogen Mustard Modified by Long Chain Alcohols and Amines