林可霉素

用薄层色谱法检测林可霉素B组分

Determination of lincomycin B component by thin layer chromatography

TiO2光催化降解林可霉素废水的研究

Photocatalytic degradation of lincomycin wastewater by TiO_2 catalysis

前言：目的：实验降低盐酸林可霉素B组分的含量。

Objective : To reduce the content of constituents B of Lincomycin Hydrochloride .

结果：降低盐酸林可霉素B组分1.7%以下。

Results : reduce constituents B of Lincomycin Hydrochloride to below 1 . 7 % .

混合醇萃取用以降低林可霉素产品中B组分含量的工艺研究

Process for preparation of lincomycin with lower content of component B by extraction with long-chain alcohol

pH值对盐酸林可霉素输液的影响

Effect of the pH value on lincomycin hydrochloride injection

林可霉素自控pH和连续补料发酵工艺研究

Studies on lincomycin fermentation technology in automatically controlled fermentors

复制林可霉素致豚鼠胆囊胆色素结石的模型（B组）；

The model of pigmental gallbladder stone in guinea pigs induced by lincomycin was reproduced ( group B );

结果林可霉素产品中B组分含量由5%以上降至0.5%以下，且保持了较高收率。

Results The content of lincomycin B of lincomycin product was lowered to less than 0.5 % from more than 5 % , and the overall yield was kept high .

结论盐酸林可霉素输液的pH为6.0时，样品在强光、高温、低温等条件下均稳定。因此，输液的pH上限以6.0为宜。

CONCLUSION When the pH value of lincomycin hydrochloride injection was 6.02 , the sample was stable , and the limit value of upper pH should be 6.0 .

HPLC法同时测定氯霉素滴眼液中有关物质和尼泊金酯类防腐剂盐酸林可霉素滴眼液中主药含量的测定方法改进

HPLC determination for related substances and antimicrobial agents content of chloramphenicol eye drops Improvement of the Determination Method of Main Component in Lincomycin Hydrochloride Eye Drops

各型MRS除万古霉素、呋喃妥因、利福平和林可霉素，对其余药物敏感率（S+I）%较低；

Except Nitrofurantion , Rifampin , Clindamycin and Vancomycin , MRS ( S + I ) % To the rest antibiotics was more less than MSS .

实验结果表明，Cooper方程式能很好地符合螺旋霉素、林可霉素、四环素和青霉素的生物检定数据。

Experimental results have revealed Cooper Equation to be well served to the assay of spiramycin , lincomycin , tetracycline and penicillin G.

采用单相中温升流式厌氧污泥床（UASB）反应器厌氧生物工艺处理含有有毒难降解有机物的林可霉素生产废水。

The high strength Lincomycin production wastewater containing toxic and refractory substances treated by lab scale mesophilic UASB reactor was described .

结论用正辛醇、异癸醇、稀释剂按2∶6∶2混合体系作萃取剂的新提取工艺，可生产B组分含量较低的林可霉素，且收率高，成本低。

Conclusion The new process in which octanol , iso-decanol and deluent ( 2 ∶ 6 ∶ 2 ) were mixed as extractant may produce lincomycin with lower B component content , and is characterized by higher yield and lower cost .

林可霉素相关物质的LC-ESI-MS研究

LC - ESI - MS analysis of relative substances of lincomycin

1991年，主产品盐酸林可霉素于国内同类产品中首次通过美国FDA认证；

In1991 , Lincomycin Hydrochloride , the major product of the company , was certified by FDA for the first time among all products of its kind in China .

在相图中发现随着萃取剂B浓度增加，平衡线的斜率逐渐减小，即萃取相中林可霉素浓度与萃余相中林可霉素浓度比值逐渐增加，萃取率逐渐上升。

In phase graph , some rules is learned , which slope of equilibrium of curves is decrease with the increase of volume fraction of extractant B , that is the ratio of concentration of lincomycin in extractant and in raffinate gradually increasing , and extraction was so .

探讨了SBR和PAC-SBR反应器处理盐酸林可霉素原料液生产废水过程中活性污泥特征的变化。

The wastewater from Lincomycin Hydrochloride production is treated with SBR reactor and PAC-SBR reactor , and the characteristics of the active sludge during treatment process is discussed .

林可霉素高产菌株HBP-46号的筛选

The Screen of HBP-46 ~ # : A High Producing Strain for Lincomycin

北京地区GBS的红霉素和林可霉素耐药率从1998年到1999年分别从8%增加到16%和从20%增加到28%；

The rate of erythromycin resistance increased from 8 % in 1998 to 16 % in 1999 in Beijing , while the rate of lincomycin resistance increased from 20 % to 28 % in that period .

结论：成功筛选出高产林可霉素的菌株HBP-46号。

Conclusion : HBP 46 # , the high producing strain for lincomycin is screened out successfully .

根据文献数据以及回归得到的参数，用UNIFAC法计算了林可霉素的相平衡常数，与实验所得数据误差相比除个别数据外部在30%以内，基本满足了工程计算的需要。

Equilibrium coefficient of lincomycin was calculated by UNIFAC method according to the literature data and fitted data . Error of value is less than 30 % compared with experimental ones expect one or two , which can meet the needs of the engineering calculation .

电位滴定-水溶液银量法测定盐酸林可霉素注射液中氯化钠的含量

Determination of sodium chloride in Lincomycin Hydrochloride Injection by potentiometric-argentometric titration

牛奶速冻法在林可霉素菌种保藏中的应用

Storage of strain producing lincomycin by method of milk rapid cooling

膜分离技术在林可霉素发酵液分离浓缩中的应用

Concentration and separation of lincomycin from its broth by membrane technology

林可霉素水溶性粉剂对由魏氏梭菌引起的鸡坏死性肠炎的药效研究

Pharmacodynamical study of lincomycin soluble powder for necrotic enteritis in chickens

氮离子注入林可霉素产生菌诱变高产菌株

Breeding of high lincomycin-producing strains by nitrogen ion-beam injection mutagensis

盐酸林可霉素造成小鼠肠道菌群失调规律的研究

The effect of lincomycin on the intestinal flora of mice

旋光法测定发酵液中林可霉素的含量

Assay of lincomycin in fermentation liquor by optical rotation measurement