朊病毒病

根据本文报告经病理证实的人朊病毒病14例。

Fourteen cases of human prion disease were pathologically confirmed .

朊病毒病动物模型说明早在潜伏期之前淋巴网状组织就已经受到牵涉，以此为据可以可靠的预测将来的神经病变。

Animal models of prion disease suggest that lymphoreticular involvement occurs early in the incubation period and reliably predicts future neurological disease .

PrP的胞内运输与朊病毒病

The Role of Intracellular Trafficking of PrP in Prion Diseases

人的朊病毒病有多种，其中10&15%可以遗传，并与人的朊病毒蛋白基因PRNP的突变有关，另有85%呈散发性。

Human TSEs or prion diseases are described as infectious , inherited , and sporadic form . Approximately 10-15 % of the human prion disease is inherited .

朊病毒病（又称传染性海绵状脑病）的病原是致病型朊蛋白，在牛脑中聚集能够造成牛海绵状脑病（bovinespongiformencephalopathy，BSE）。

A converted form of the normal cellular prion protein ( PrP ) accumulates in the bovine brains with bovine spongiform encephalopathy ( BSE ) . This so-called scrapie-associated prion protein ( PrPSc ) found in many animals and humans is the pathogen of prion diseases .

21世纪的库鲁病：一种潜伏期很长的获得性人朊病毒病

Kuru in the 21st century-an acquired human prion disease with very long incubation periods

朊病毒病研究进展

Advance in the Study of Prion Diseases

目的制备1433特异性抗体并试用于朊病毒病患者脑脊液标本检测。

Objective Preparation of specific antibody of neuron protein 14 3 3 and application for the diagnosis of prion diseases .

朊病毒是Prion病的病原体，朊蛋白（PrPc）是朊病毒在细胞内的正常表现形式，它以GPI锚定的方式定位在细胞膜上，在各物种间高度保守。

The normal , cellular prion protein , designated PrPc , is a glycosylphosphatidylinositol ( GPI ) - anchored membrane protein that is highly conserved in mammalian species .

脑神经退行性疾病中的有机化学&朊病毒（疯牛病）中的蛋白物理有机化学和自由基化学

Organic Chemistry in Neurodegenerative Disorders Physical Organic Chemistry and Bioorganic Free Radical Chemistry of Prion Protein

口蹄疫不是由朊病毒引起的病，很少对动物有致命性，也很少传染给人。

It is not a prion disease . It is seldom fatal to animals and is rarely transmissible to humans .

他说：根据多部电影，辐射以及朊病毒、疯牛病、麻疹和狂犬病等现有病情突变也会造成类似僵尸的症状。

Films have included radiation as well as mutations of existing conditions such as prions , mad-cow disease , measles , and rabies , he said .

必须转变固有的医学思维模式来看待朊病毒之谜，并从哲学角度探讨了朊病毒病的出现。

We should transform the traditional medical thinking model to research the mystery of prion . The appearances of prion diseases are discussed from philosophical angle .

目的制备朊蛋白N端和C端多肽特异性抗体，并对ELISA方法在朊病毒病检测中的应用进行研究。

Objective To prepare the specific antibodies against PrP N-and C-terminal segments individually based on previous works and to evaluate ELISA method in diagnosis of prion disease .

TSEs由细胞型朊病毒蛋白PrP~C转变成致病型朊病毒蛋白PrP~（Sc）引起，因此也称朊病毒病。

Based on the protein only hypothesis , TSE is caused by the conversion of a normal cellular prion protein ( PrP ~ C ) into a pathogenic , infectious isoform , which has been commonly referred to as scrapie prion protein ( PrP ~ Sc ) .