微管结合蛋白

资料综合：①由微管结合蛋白Tau形成的聚集体是许多神经退行性疾病的主要病理特征之一。

DATA SYNTHESIS : ① Pathological aggregation of the microtubule-associated protein Tau is a common feature of many neurodegenerative diseases .

目的：检查老龄和青年大鼠睾丸间质组织中tau蛋白和微管结合蛋白的表达情况，籍此评价老龄大鼠睾丸衰退的发生机制。

Objective : To examine the expression of the tau protein and microtubule-associated proteins in the testis interstitium of aged and young rats .

醋酸铅对ST-8814细胞神经丝蛋白、微管结合蛋白mRNA水平的影响

Effect of lead acetate on mRNA expression of neurofilament protein and microtubule associated protein in ST-8814 cell line

目的：构建表达人微管结合蛋白4微管结合区（Microtubule-BindingDomain，MTB）的大肠杆菌工程菌。

Objective : To construct the engineered E. coli . strain which expresses microtubule-binding domain ( MTB ) of human microtubule-associated protein 4 ( MAP4 ) .

以C8柱为固定相，研究了微管结合蛋白2中两段重要肽段（肽1，肽2）和猪胰岛素在反相色谱上的保留行为。

The Chromatographic retention behaviors of two peptides ( peptide 1 and peptide 2 ) from microtubule _ associated protein 2 ( MAP2 ) and porcine insulin in C8 hydrophobic ligand were studied .

最近的研究的发现，在果蝇和爪蟾系统中，AuroraA能够磷酸化TACC（Transformingacidiccoiledcoil）蛋白，并招募TACC蛋白到中心体上，与微管结合蛋白一起参与调控中心体微管的稳定性。

Recently , Xenopus and Drosophila transforming acidic coiled coil ( TACC ) proteins have been found to be the substrates of Aurora A. After phosphorylation by Aurora A , TACC proteins are recruited to centrosomes , and then contribute to modulating centrosomal microtubule stability with microtubule associated proteins .

人微管结合蛋白4微管结合区的体外表达

Expression of Microtubule Binding Domain of Human Microtubule-associated Protein 4

结论：人微管结合蛋白4微管结合区具有微管结合活性。

Conclusion : recombinant MTB proteins of human MAP4 retained the MT-binding activity .

植物微管结合蛋白的研究是目前植物细胞骨架研究的前沿领域。

Study of MAPs is now the cutting-edge research in the field of the cytoskeleton researches .

微管结合蛋白是一类能够特异地与微管结合，参与调节微管结构与功能的结合蛋白。

Microtubule-associated proteins ( MAPs ) bind to microtubules specifically and are involved in the regulation of microtubule dynamics and its related functions .

微管结合蛋白对微管骨架的组织和功能调控有重要的作用。

Microtubule associated proteins ( MAPs ) are the major factor involved in the regulation of microtubule ( MT ) dynamics and organization for functions of the MT cytoskeleton .

在细胞分裂过程中，有丝分裂纺锤体控制染色体的分离。纺锤体是具有双极性的结构，由微管和微管结合蛋白组成。

Chromosome segregation during cell division is orchestrated by the mitotic spindle , a bipolar apparatus composed of microtubules and their associated proteins .

微管列阵的转换需要微管结合蛋白的参与。

Microtubule-associated proteins ( MAPs ) are involved in the transformation of MT arrays .