己酮可可碱

己酮可可碱增强（E）-（2′）-脱氧-氟亚甲基胞苷的细胞毒性和对宫颈癌细胞的放射增敏作用

Pentoxifylline Enhances Cytotoxicity and Radiosensitization of ( E ) - 2 ′ - deoxy-2 ′ - ( fluoromethylene ) Cytidine in Cervical Cancer Cells

己酮可可碱（pentoxifylline，PTX）是一种非选择性磷酸二酯酶抑制剂，被广泛用于治疗血管性疾病。

Pentoxifylline ( PTX ), an unselective phosphodiesterase inhibitor , has been used widely to treat vascular disease .

己酮可可碱对NOD小鼠1型糖尿病的影响

Effect of Pentoxifylline on type 1 diabetes in NOD mice

己酮可可碱对血吸虫病肝纤维化小鼠肝组织Bcl-2，Bax表达的影响

Effects of pentoxifylline on expressions of hepatic Bcl-2 and Bax protein in schistosomiasis mice with liver fibrosis

己酮可可碱预防NOD鼠1型糖尿病的机理研究

A study on the prevention of type 1 diabetes in NOD mice by Pentoxifylline

结论己酮可可碱可能通过影响肝脏NF-κB信号通路和增加肝细胞IRS2表达，从而有助于改善非酒精性脂肪性肝炎大鼠肝脏胰岛素抵抗。

Conclusions PTX could influence NF - κ B signaling pathway and IRS expression in livers of NASH rats , which might be involved in the improvement of hepatic insulin resistance .

己酮可可碱对p38丝裂原激活蛋白激酶激活的影响

Effects of pentoxifylline on activation of p38-mitogen-activated protein kinase

己酮可可碱（PTX）可减轻油酸肺损伤肺部炎细胞浸润，减少TNFα在血浆和BALF中的含量。

Treatment with pentoxifylline ( PTX ) markedly reduced pulmonary infiltration of inflammatory cells and inhibited TNF α formation both in BALF and plasma .

目的利用稳定的大鼠肝缺血再灌注模型，通过分组对照研究，探讨联合与单独应用褪黑素（MT）和己酮可可碱（PTX）对肝脏缺血再灌注损伤（IRI）的保护作用及相关机理。

Objective To investigate the effect of melatonin ( MT ) and pentoxifylline ( PTX ) in hepatic ischemia and reperfusion in rats .

目的：探讨己酮可可碱（PTX）对内毒素（LPS）诱导的急性肺损伤肺微血管通透性的影响。

Objective : To study the effects of pentoxifylline ( PTX ) on pulmonary microvascular permeability of LPS induced acute lung injury .

目的探讨细胞间粘附分子-1（ICAM-1）在连续不卧床性腹膜透析（CAPD）患者的腹膜炎症过程中的作用及己酮可可碱的保护效应。

Objective To investigate the role of ICAM - 1 in the process of peritoneum inflammation in CAPD patients and protective effects of pentoxifylline FTX .

目的：分析吸入己酮可可碱（pentoxifylline，PTX，商品名潘通）治疗慢性阻塞性肺疾病（COPD）患者的疗效。

Objective : To evaluate the effect of pentoxifylline ( PTX ) on patients with chronic obstructive pulmonary disease ( COPD ) in exacerbation status .

目的：制备己酮可可碱（PTX）缓释胶囊，并考察其体外释药特性。

OBJECTIVE : To prepare pentoxifylline ( PTX ) modified release capsule and to investigate its in vitro drug release characteristics .

目的探讨己酮可可碱（PTX）和地塞米松防治内毒素（LPS）诱导急性肺损伤（ALI）的作用机制。

Objective To explore the main actions of pentoxifylline ( PTX ) and dexamethasone on lipopolysacharide ( LPS ) induced acute lung in jury ( ALI ) in rats .

目的探讨己酮可可碱（PTX）对胸部开放伤海水浸泡致急性肺损伤（ALI）犬肺微血管通透性的作用。

Objective To investigate effect of pentoxifylline on pulmonary microvascular permeability of dogs incurred acute lung injuries induced by which chests with open trauma were immersed in seawater .

目的探索己酮可可碱（PTX）吸入对慢性阻塞性肺疾病（COPD）患者血浆内皮素（ET-1）的影响及临床意义。

Objective To investigate the effects and clinical significance of pentoxifylline ( PTX ) inhalation on blood plasma ET 1 in patients with Chronic Obstructive Pulmonary Disease ( COPD ) .

目的探讨肺保护性通气联合己酮可可碱对胸部开放伤后胸腔内海水致急性肺损伤（ALI）的救治疗效。

Objective To study the effects of lung protective ventilation and pentoxifylline ( PTX ) on acute lung injury ( ALI ) caused by open chest wound with seawater inundation of the thoracic cavity .

目的探讨己酮可可碱（Pentoxifylline，PTX）对非肥胖糖尿病（NOD）小鼠1型糖尿病发病率、胰岛炎的影响及其机制。

Objective To study the effectiveness of phosphodiesterase inhibitors Pentoxifylline ( PTX ) on type 1 diabetes in non obese diabetic ( NOD ) mice and its possible mechanism .

结论应用肺保护性机械通气治疗胸腔海水致ALI可以起到良好的呼吸支持作用，己酮可可碱能有效的抑制肺内、外炎症反应。

Conclusion Lung protective ventilation is an effective method in the treatment of ALI caused by open chest wound with inundation of seawater in thoracic cavity . PTX can inhibit inflammatory reaction in the lung and peripheral blood .

方法：对己酮可可碱氯化钠注射液的1∶2（0.5mg·ml-1）进行了干扰试验。

Method : inhibition and enhancement test was carried out to the 1 ∶ 2 dilution ( 0.5 mg · ml - 1 ) of pentoxifylline sodium chloride injection .

目的观察己酮可可碱（PTX）和阿苯达唑（ABZ）单独及联合用药对小鼠继发性泡球蚴病的疗效。

Objective To observe the effect of pentoxifylline ( PTX ), albendazole ( ABZ ), and a combination of PTX and ABZ in mice infected with Echinococcus multilocularis ( E.

己酮可可碱组在腹腔注射己酮可可碱（100mg/kg）后1h进热仓。观察肛温变化及大鼠在热仓中的存活时间。

In the pentoxifylline group , the rats were put into the heat chamber at 1 hour after they there given intraperitoneal injection of pentoxifylline , and the change of the rectal temperature and survival time of the rats in the heat chamber were observed .

方法在体外培养的精子悬液中加入不同浓度的己酮可可碱和孕酮处理，通过CTC染色，镜检计数各型精子的百分率。

METHODS Different concentration and progesterone ( PF ) were added to the liquid containing sperm which were cultured in vitro . Through chlortetracycline ( CTC ) fluoresence assay , we had counted the percent of different type sperm of each groups under microscope .

己酮可可碱（PTX）是一种从可可豆中提取的生物碱，其对生物体作用广泛，现已被广泛应用于医疗等领域，但在运动医学领域未见报道。

Pentoxifylline ( PTX ) is an alkaloid extracted from cacao which has high biological activity . Owning to its extensive effect on our body PTX has been widely used in medicine field , but in sports medicine field it is less reported .

目的：观察己酮可可碱（PTX）对内毒素血症（ETM）大鼠心肌组织肿瘤坏死因子-α（TNF-α）基因表达的影响，探讨PTX对ETM大鼠心肌组织可能的保护机制。

AIM : To investigate the effects of pentoxifylline ( PTX ) on myocardial gene expression of tumor necrosis factor α( TNF α) in rats with endotoxemia ( ETM ), and to evaluate the mechanism underlying PTX on the protection of rats myocardium with ETM .

【结果】①0.3mg/mL己酮可可碱与对照组相比，可下调胶原ⅠmRNA表达32%（P<0.01），其抑制作用呈时间依赖性关系，作用16h抑制作用达高峰（0.790vs0.426，P<0.001）。

[ Result ] ( 1 ) 0.3 mg / mL PTX inhibited the type ⅰ collagen mRNA by 32 % ( P < 0.01 ) in time-dependent manner . The peak of inhibition was at 16 hr ( 0.790 vs 0.426 , P < 0.001 ) .

结果：将己酮可可碱葡萄糖注射液稀释2倍后对鲎试剂凝集反应没有干扰作用，用标示灵敏度为0.25EU/mL的鲎试剂检测细菌内毒素是有效的。

Results : The tachypleus amebocyte lysate has no interfered by the pentoxifylline glucose injection diluted 2 times in the coagulate reaction , so it is valid to use the sensitivity of TAL 0.25EU/mL to test bacterial endotoxin .

结论：己酮可可碱对胰腺移植再灌注损伤有保护作用。

Conclusion : The pentoxifylline could palliate pancreas transplantation ischemia-reperfusion injuries .

己酮可可碱对人精子运动参数的影响

The effects of pentoxifylline on the movement parameters of human spermatozoa

己酮可可碱能减轻神经病理性疼痛大鼠痛觉过敏的发展

Pentoxifylline attenuates the development of allodynia in rats with neuropathic pain