左归丸

左归丸对老年大鼠大脑皮质8-羟基脱氧鸟苷酸的调节作用

Effect of Zuogui Wan on 8 - hydroxy - 2 ′ - deoxyguanosine of Neocortex of Aging Rats

目的探讨老龄大鼠大脑皮质基因组DNA中8羟基2′脱氧鸟苷（8OHdG）变化规律和左归丸的调节作用。

Purpose To explore the altered concentrations of 8 hydroxy 2 ′ deoxyguanosine ( 8 ? OH dG ) in cerebral genome of aging rats and regulative effect of Zuogui Wan ( ZGW ) on it .

左归丸含药血清对成骨细胞IL-1、IL-6和COX-2表达的影响

Effects of Serum Containing Zuogui Pill Substances on the Expression of IL-1 , IL-6 and COX-2 in Osteoblasts in vitro

Akt信号通路在左归丸抑制左旋单钠谷氨酸大鼠神经细胞凋亡中的作用

Role of Akt signal pathway in inhibition of neuronal apoptosis by Chinese medicine Zuogui pill in adult rats treated with monosodium glutamate

左归丸可以有效防治PMOP。

Zuogui Pill can prevent and cure PMOP effectively . 3 .

结论左归丸能改善POF小鼠卵巢免疫性炎症的损伤，对POF具有一定的预防和治疗作用。

Conclusion Zuogui Pill can improve the ovarian injury induced by immune inflammation and has some prevention and treatment action on POF .

14d开始，模型组、左归丸组大鼠MSCs的ALP染色阳性率明显低于正常组，有统计学意义。

From 14d , the rate of ALP stained positive cells of model group and Zuo gui pill group MSCs was significantly lower than normal group .

骨向诱导18、21d时，模型组、左归丸组MSCsALP表达量明显低于正常组，有显著性差异。

On 18 、 21d of differentiating into osteoblasts , MSCs ALP expression of normal group was significantly higher than model group , Zuo gui pill group .

结论在去势状态下，左归丸可能是通过抑制成骨细胞IL-1、IL-6和前列腺素E2（PGE2）的分泌，进而达到治疗骨质疏松的作用。

Conclusion The serum containing Zuogui pill substances can inhibit the secretion of IL-1 , IL-6 and PGE_2 , which may be one of the mechanisms of action of Zuogui Pill treatment for osteoporosis .

左归丸对E2含量无显著性影响，但对IL1和IL6活性有明显的抑制作用。

Ez decrease at a large amplitude greatly and IL-1 and IL-6 increased significantly , and Zuo Gui Pill did not have significant effect on E2 content , but had a significant inhibition on IL - 1 and IL - 6 activities .

目的探讨左归丸对免疫性卵巢早衰（POF）小鼠生殖内分泌及抗卵巢抗体（AoAb）的影响。

Objective It is to explore the influence of Zuogui pill on reproductive endocrine and antiovarian antibodies ( AoAb ) in immune premature ovarian failure ( POF ) rats .

目的观察Akt信号通路在左旋单钠谷氨酸（MSG）和左归丸（ZGW）对新生大鼠体外培养海马神经干细胞（NSC）和子细胞凋亡中的作用。

Objective To observe the function of Akt signal pathway on apoptosis of hippocampus neural stem cell ( NSC ) and daughter-cells of newborn rats treated with MSG and Zuogui Pill ( ZGP ) .

结果：（1）左归丸加味改善ITP患者中医临床症状的总有效率为83.3%，优于胺泰素片组（P<0.05）；

Result : It was suggested that : ( 1 ) The total effective rate of modified kidney-yin-tonifying Bolus ameliorating the ITP suffers TCM clinical symptoms , which is superior to that of An-tai-su pills group ( P < 0.05 ) .

左归丸现代临床应用和实验研究进展

Progresses in Modern Clinical Applications and Experimental Researches of Zuogui Pill

左归丸具有针对性调节作用的基因有12条。

Zuogui Pill can aim directly at adjusted 12 genes ' expression .

结论左归丸可能具有改善免疫性卵巢早衰小鼠症状的作用。

ConclusionZuogui pill may have some prevention and treatment action on POF .

目的：探讨左归丸对骨质疏松症的治疗作用。

Objective : To study effect of treatment of ZUOGUEI Pill on osteoporosis .

左归丸对去势雌性大鼠子宫和阴道的影响

Effect of Zuogui Pill on the Uterus and Vagina of Ovariectomized Female Rats

左归丸对MSG-大鼠胸腺及淋巴细胞增殖反应的影响

Effect of Zuogui Pill on the Thymus and Lymphocyte Proliferation in Rats Treated with MSG Neonatally

妈富隆配合左归丸治疗青春期功血（肝肾阴虚证）的临床观察

Marvelon Pill Zuogui Treatment with Adolescent Dysfunctional Uterine Bleeding ( Liver Kidney-yin Deficiency Syndrome ) Clinical Observation

左归丸对D-半乳糖致亚急性衰老大鼠抗氧化能力影响的实验研究

Experimental Study about the Effect of Zuogui Pill on Anti-Oxidation Capability of Subacute Aging Rats Induced by D-Galactose

方法：复制MSG-肝再生-大鼠模型，给予左归丸5g/kg灌胃治疗2周后，观察再生肝组织基因表达谱的变化规律。

Methods Copying MSG-liver regeneration-rat model , treated group was treated by Zuogui Pill ( 5g / kg ) for 2 weeks .

结论：左归丸水提液对低钾所致的大鼠小脑颗粒神经元凋亡有保护作用，PI3K/Akt信号传导通路参与其作用。

Conclusion Water extract from Left-Restoring Pill can protect from apoptosis of primary cultured cerebellar granule neurons induced by repolarization , and this effect was PI3K / Akt signaling pathway-dependent . 〔

同时概述了研究对象左归丸、右归丸和济生肾气丸三种中药复方产品的组方及其各单味药材的主要化学成分。

On the other hand , prescriptions of Zuogui pills , Yougui pills and Jisheng shenqi pills , and the main chemical components of each herbal medicine contained in the prescriptions are outlined .

说明左归丸在改善经色深红、经血粘稠、潮热颧红、头晕、耳鸣、大小便异常方面效果显著，因此左归丸能较明显改善降调节后出现的肾阴亏虚证候。

That Zuogui Pill in improving the color dark red 、 blood viscosity 、 hot flashes red cheeks 、 dizziness 、 tinnitus 、 the size of anomaly effect , therefore Zuogui pill can obviously improve the appearance after down regulation of kidney yin deficiency syndrome . 6 .