大环内酯抗生素

阿奇霉素（Azithromycin，ATM）是新一代的大环内酯抗生素，它与传统的红霉素相比有许多优点。

Azithromycin ( ATM ) is one of the new generation of macrolides and has several advantages over traditional macrolides such as erythromycin .

从链霉菌FR－008中克隆出一个七烯大环内酯抗生素的生物合成基因簇，基因置换试验证实克隆的基因片段与抗生素生物合成直接相关。

Genes for biosynthesis of a Streptomyces sp. FR-008 heptaene macrolide antibiotic faith antifungal and mosquito larvacidal activity were cloned in E.

多形核中性粒细胞对大环内酯抗生素内在化的特殊意义

Special Significance of Polymorphonuclear Neutrophils in Macrolides Endocytosis

目的了解大环内酯抗生素抗炎效应的细胞学机制。

Aim To evaluate the cellular mechanism of the anti inflammatory action of macrolide .

为了解大环内酯抗生素抑制慢性炎症气道粘液高分泌的分子机制。

To investigate the molecular mechanisms of mucous hypersecretion inhibited by macrolides in chronic inflammatory airway .

当大环内酯抗生素与靶点结合时，会堵塞肽通道，抑制细菌蛋白质的合成，从而产生抗菌作用。

The macrolides can inhibit bacterial protein synthesis by blocking up the peptide tunnel when they bind to the binding sites , bringing forth antibacterial activity .

Real-timePcR检测肺炎支原体对大环内酯类抗生素耐药基因

Detection of macrolide resistance in Mycoplasma pneumoniae by real-time PCR

目的探讨大环内酯类抗生素对丙烯醛诱导的大鼠黏液高分泌模型的干预作用，以及核因子-κB（NF-κB）在黏液高分泌发病机制中的作用。

Objective To investigate the effects of macrolide on and the role of nuclear factor - κ B ( NF - κ B ) in airway mucus hypersecretion stimulated by acrolein in rats .

C2-C7低级脂肪酸的气相色谱分析及其在大环内酯类抗生素结构鉴别上的应用

Gas chromatographic analysis of c_2-c_2 lower fatty acids and its application on structural identification of macrolide antibiotics

结果与结论：应根据当地CAP病原体及耐药菌流行病学资料，合理选择使用大环内酯类抗生素。

RESULTS CONCLUSION : On the basis of local pathogens of CAP and epidemiological data of drug-resistance bacteria , macrolide antibiotics will be rationally chosen and used .

结论：大环内酯类抗生素的黏液抑制性调理作用可能是由于其内在化于中性粒细胞抑制NE释放而间接实现的。

Conclusion : Suppressive effect on mucous of macrolides is indirectly realized by inhibiting NE release , dued to macrolides endocytosis in neutrophil .

HPLC-ESI-MS法测定鸡肝中的大环内酯类抗生素

Determination of macrolides in chicken liver by HPLC-ESI-MS

用非大环内酯类抗生素治疗混合感染可同时控制Mh感染，其治愈率与单用抗Mh抗生素无明显差异。

Mh infection can be controlled simultaneously through treatment of mixed Mh infection with non-macrolides antibiotics , showing a recovery rate similar to that obtained by administering anti Mh antibiotics .

通过Blast软件进行分析，将其与Mh标准敏感株PG21核苷酸序列进行比较，分析核苷酸突变及其与大环内酯类抗生素耐药性的相关性。

The nucleotide sequences of Mh clinical isolates resistant to josamycin were compared with the reference strain 's counterparts with Blast software , and the correlation of nucleotide mutation with the resistance to macrolides was analyzed .

首选大环内酯类抗生素防治PRDC的理论依据和有效用法

First Choosing Macrolide Antibiotic Provides Prevention and Therapy Theory Foundation and Valid Usage of PRDC

以琼脂对倍稀释法测定新大环内酯类抗生素（azithromycin、clarithromycin及罗红霉素）等抗菌药对202株临床分离菌的最低抑菌浓度。

The in vitro activities of new macrolides ( azithromycin , clarithromycin and roxithromycin ) and other antimicrobial agents against 202 clinical isolates were tested using agar dilution method .

罗红霉素为半合成的大环内酯类抗生素，通过与敏感细菌核蛋白体的50s亚基结合，抑制蛋白质的合成，从而起到抗菌作用。

Roxithromycin ( RXM ), as a semisynthetic macrolide antibiotics , could disrupt bacterial protein synthesis by combining with 50s bacterial subunit , thereby exhibited antibacterial effects .

大环内酯类抗生素（macrolideantibiotics，MALs）是一类化学结构和抗菌作用相近的碱性抗生素群，属于中谱抗生素。

Macrolide antibiotics ( MALs ) is a kind of chemical structure and antibacterial activity similar to the basic antibiotic group , belong to the spectrum antibiotics .

大环内酯类抗生素M-90的早期鉴别

Early Identification of Macrolide Antibiotic M - 90

方法应用微量肉汤稀释法检测106株Mh对5种大环内酯类抗生素的敏感性，以MIC值大于或等于标准敏感株的4倍为参考标准，从中筛选临床耐药株。

Method : Susceptibility tests of 106 Mh clinical isolates to 5 macrolides were performed by using broth microdilution method , according to the criteria of MICs being 4-fold or higher than the susceptible reference strain 's counterparts .

方法：通过文献复习，对CAP常见病原体、大环内酯类抗生素特点、耐药性以及各国指南对大环内酯类抗生素治疗CAP的规定进行分析和讨论。

METHODS : By reviewing literatures , common pathogens of CAP , the characteristics of macrolide antibiotics , their drug resistance and regulations about macrolide antibiotics in the treatment of CAP , which were set up by the guide of every country were analyzed and discussed .

应用固相萃取（SPE）及LC-MS/MS技术，建立了水中痕量大环内酯类抗生素即红霉素、脱水红霉素、罗红霉素的分析方法，优化了固相萃取、液相色谱-质谱/质谱等相关条件。

The determination of macrolide antibiotics in water was performed using solid phase extraction ( SPE ) followed by a combined liquid chromatography ( LC ) and tandem mass spectrometry ( MS / MS ) procedure under the multi-reactive model .

罗红霉素（RXM）是一种广泛应用的大环内酯类抗生素，其抗菌谱与红霉素相似，对革兰氏阳性菌有强大的抗菌作用。

Roxithromycin is a widely-used antibacterial macrolide , which has an antibacterial spectrum in vitro similar to that of erythromycin , with strong activity against Gram-positive bacteria .

泰拉霉素（Tulathromycin）为最新开发的兽用大环内酯类抗生素，有关研究显示大环内酯类可能通过非抗菌活性的免疫调节作用发挥疗效。

Tulathromycin is a novel macrolides antibiotic used in veterinary . Relative researches indicate that macrolides may exert immunomodulation effect through actions other than its antimicrobial properties .

简要介绍大环内酯类抗生素发展近况，讨论了大环内酯类抗生素的作用机制、耐药机制、构效关系及泰利霉素（Telithromycin）和ABT-773（Cethromycin，喹红霉素）的药理、临床性质。

The Development of Macrolide Antibiotics was introduced briefly and the action mechanism , structure-activity relationships , and resistant mechanisms of the macrolides were discussed . The pharmacological and clinical characteristics of Telithromycin and ABT-733 ( Cethromycin ) were reviewed as well .

肺炎链球菌对抗菌药物的耐药性调查及对大环内酯类抗生素耐药机制研究

Antimicrobial resistance of Streptococcus pneumoniae and mechanisms of resis-tance to macrolides

大环内酯类抗生素促进胃排空的分子机制研究

Molecular Mechanism of Prokinetic Effect of Macrolides on Promoting Gastric Emptying

肺炎链球菌对大环内酯类抗生素的耐药状况及耐药机制研究进展

Update of macrolide resistance in Streptococcus pneumoniae and the underlying mechanism

毛细管电泳&电化学发光联用检测大环内酯类抗生素

Capillary Electrophoresis with Electrochemiluminescence Detection for the Analysis of Macrolide Antibiotics

大环内酯类抗生素致过敏性休克78例文献分析

Anaphylactic Shock Induced by Macrolides : Literature Analysis of 78 Cases