固体分散体

目的：制备长春西汀固体分散体，提高其溶出速度和程度。

OBJECTIVE To prepare vinpocetine solid dispersion and improve the dissolution of vinpocetine .

固体分散体是由药物与载体混合制成的高度分散的固体分散体系。

Solid dispersion is a high dispersion system which mixed by drug and carrier .

热差分析及粉末X衍射结果表明固体分散体中槲皮素呈非结晶形式；

The results of DSC and PXRD showed that the quercetin in solid dispersion was amorphous form .

在不同浓度组下金丝桃苷吸收不具有显著性差异（P0.05）。4.金丝桃苷固体分散体研究。

In different concentrations the hyperin absorption does not have a significant difference ( P0.05 ) . 4 .

吡罗昔康PEG固体分散体中载体组成与制剂的体内外特性

In vitro and in vivo characteristics of two dosage forms of piroxicam solid dispersion system with different PEG bases

结果与纯姜黄素相比，姜黄素固体分散体（姜黄素：PVP的质量比为1：8）溶解度提高了870倍，溶出速度明显增大。

RESULTS Compared with pure curcumin , the solubility of solid dispersion increased 870 folds .

齐墩果酸固体分散体胶囊的溶出度测定及Weibull分析

Dissolution Property of Oleanolic Acid from three preparations Determined by HPLC and Analyzed by Weibull 's Model

结论：选用0.3%的SDS水溶液作为溶出介质，便于通过溶出度试验来筛选固体分散体处方。

Conclusion : Formulation of nitrendipine solid dispersion could be well evaluated through dissolution tests if 0.3 % SDS solution was selected as dissolution medium .

乙基纤维素固体分散体中5F释放度影响因素研究

Investigation on the factors affecting dissolution of 5F from ethylcellulose solid dispersions

方法以不同分子量不同比例的聚乙二醇为载体，以熔融法制备固体分散体，并进行体外溶出度研究和DSC扫描。

METHODS Preparing the solid dispersion by melting method at different drug-to-PEG ratios with different PEG moleculars and studying the preparation with dissolution rate in vitro and DSC method .

结果：卟恶丙嗪PEG6000固体分散体是一种简单低共熔混合物，卟恶丙嗪以超细结晶状态分散在PEG载体中。

RESULTS The oxaprozin-PEG 6000 solid dispersion was a simple-lower-eutectic compound . The oxaprozin was dispersed in PEG 6000 as micro-crystallite form .

结果：溶出介质1.0%和0.5%的十二烷基硫酸钠（SDS）水溶液可以满足漏槽条件，但药物释放较快，固体分散体间的溶出行为差异不明显；

Results : The drug release rate from four kinds of nitrendipine solid dispersions was quite faster in 1.0 % or 0.5 % SDS solutions than in 0.3 % SDS solution .

目的采用固体分散体技术改善长春西汀（VIN）的体外溶出特性。

Objective To prepare vinpocetine ( VIN ) solid dispersion ( SD ) and improve the dissolution profile of vinpocetine .

应用聚乙二醇（PEG）6000（2）和号丙烯酸树脂（3）为混和载体，用溶剂法制备了盐酸尼卡地平（1）肠溶缓释固体分散体。

Nicardipine hydrochloride ( 1 ) intestinal dissolved sustained release solid dispersion was developed using PEG 6000 ( 2 ) and acrylic resin ⅱ( 3 ) as mixed carrier by the solvent evaporating method .

当尼群地平载体比例达1∶4时，尼群地平从固体分散体中的溶出速度明显大于尼群地平纯药和尼群地平载体（1∶8）物理混合物（P0.05）。

When the nitrendipine / carrier ratio is 1 ∶ 4 , the dissolution rate of nitrendipine in solid dispersions is higher than that of nitrendipine or nitrendipine carrier ( 1 ∶ 8 ) physical mixtures ( P 0.05 ) .

方法：采用溶剂法制备固体分散体，进行溶解度、溶出速率测定，导数热重分析（DTG）。

Methods : The solid dispersion was prepared by solvent method . The solubility , the dissolution rate and the derivative thermogravimetry ( DTG ) were determined .

结论该测定方法稳定、快速、准确、简便，可以作为5F-泊洛沙姆固体分散体中5F的质量控制方法。

Conclusion The method is reproducible , simple , rapid and accurate for the determination of 5F in the solid dispersions .

由于水飞蓟素在水中几乎不溶，本文首先采用溶剂法，以PVPK30为载体，制备了水飞蓟素固体分散体，以提高水飞蓟素的水溶性。

Due to aqueous insolubility of silymarin , the solid dispersion was prepared by the solvent method using PVP K30 as the hydrophilic carrier matrix .

用X射线粉末衍射法分别测定了纯载体材料、纯西沙必利、载体材料和西沙必利物理混合物以及载体材料和西沙必利固体分散体4∶1的晶体衍射峰，以确定是否有晶体存在；

Powder X-ray diffraction ( XRD ) was used to measure the diffraction peaks of pure carrier , pure cisapride , physical mixture of HPMC with cisapride ( 4 ∶ 1 ), and HPMC-cisapride solid dispersion ( 4 ∶ 1 ) to confirm the crystal existence .

目的以泊洛沙姆188（F68）为载体制备环孢素（CsA）固体分散体并考察其体外溶出。

S : AIM To prepare solid dispersions of ciclosporin ( CsA ) with poloxamer 188 ( F68 ) and examine the dissolution properties of CsA from this system .

结果PVP及PEG固体分散体在45min的溶出度分别达到原料药的9.7倍和7.5倍，固体分散体的DTA曲线中隐丹参酮的特征熔融峰消失。

Results Solid dispersion dissolutions of PVP and PEG at 45 min were 9.7 and 7.5 times as much as material drug , respectively . Characteristic melting peak of cryptotanshinone in DTA curve of solid dispersion disappeared .

方法溶剂法制备乙基纤维素固体分散体颗粒，测定其溶出度，考察各主要因素对5F释放的影响。

Methods Prepared ethylcellulose 5F solid dispersion granules by solvent method and determined the dissolution of the granules , so that the factors which affected dissolution of solid dispersion were investigated .

因此本文将APIC制备成肠溶固体分散体，并对其体内外性能和肠溶性制剂中APIC绝大部分以多糖铁分子形式吸收的可行性进行考察。

So we prepared enteric-coated APIC solid dispersion and investigated its properties in vivo and in vitro and the feasibility of APIC absorbed mainly in the form of polysaccharide-iron molecule in enteric-coated preparation .

药动实验结果显示APIC肠溶固体分散体与力蜚能给药后大鼠体内血铁浓度均有显著升高，且两种药物在本实验所选剂量范围内AUC都随给药剂量增大而增加。

The pharmacokinetic study showed that the both serum iron concentration in rats rose obviously after the administration of enteric-coated APIC solid dispersion and Niferex and the AUC of both drugs increased accordingly as the accrescence of the dosage in the dosage range chose in this experiment .

尼莫地平固体分散体和微粉的制备与增溶作用的研究

Preparation and Research of Solubilization of Nimodipine Solid Dispersion and Micropowder

辅料对尼莫地平固体分散体粉体学性质的影响

Effects of excipients on powder technology properties of nimodipine dispersion powders

高效液相色谱法测定固体分散体中氨苯砜的含量

Determination of the content of dapsone in solid dispersion by HPLC

齐墩果酸固体分散体形成和增溶机制研究

Studies on formation and solubilizing mechanism of oleanolic acid solid dispersion

滴丸制剂是一种固体分散体。

Dripping pill is a dosage form of solid dispersion .

热熔挤出法制备尼莫地平固体分散体

The Preparation of Solid Dispersions Containing Nimodipine and PVP-VA by Hot-Melt Extrusion