可逆抑制

酶学动力学研究表明，抑制包含可逆抑制和不可逆抑制两部分。

It was showed that the inhibition consisted of both reversible inhibition and irreversible inhibition through kinetics studies .

DTNB对人肌肌酸激酶不可逆抑制作用的研究

Studies on the irreversible inhibition of creatine kinase from human muscle by DTNB

EGCG抑制机理研究表明酯键是其不可逆抑制蛋白酶体的必需药效团。

One of the mechanism researches found that the ester bond of EGCG is necessary for the inhibitory activity to proteasome .

测定表明，中药何首乌提取物对FAS同时具有很强的快结合可逆抑制和慢结合不可逆抑制作用。

It is shown that extract of Chinese medicine tuber fleeceflower root ( TFR ) inhibited FAS activity by both strong reversible fast binding and irreversible slow binding inhibitions .

粗酶液的体外实验也表明，SNP对POD和CAT的抑制类型不同，前者可能是不可逆抑制，后者则可能是可逆抑制。

In vitro experiments also indicated that the inhibition of wheat POD in crude extracts by varying concentrations of SNP appeared to be irreversible in comparison with the reversible inhibition of CAT .

本文研究了DTNB对人肌肌酸激酶的不可逆抑制作用。

The irreversible inhibition of creatine kinase from human muscle during modification with DTNB has been studied .

结果表明：野靛碱和苦豆碱对羧酸酯酶活性有显著的抑制，为可逆抑制类型的非竞争性抑制作用；

The results indicate that cytisine and aloperine could inhibit carboxylesterase activity through non-competitive inhibition .

酪氨酸酶的抑制特征为可逆抑制，分为竞争性、非竞争性、混合型及缓慢结合型4种。其抑制的主要机理分别为：底物类似物结合酶的活性中心从而抑制酶活性；

The inhibition is characterized in reversibility , including four types-competitive , non-competitive , mixed and slow-binding .

结果表明，熊果甙对酪氨酸酶活性的抑制作用表现为可逆抑制效应。

The results show that the inhibition of tyrosinase by arbutin is a reversible reaction with remaining enzyme activity .

有机磷农药生物传感器已有很多报道，其设计原理大多是基于乙酰胆碱酯酶的不可逆抑制作用。

The design theory of the organ phosphorus pesticide biosensor is based on the irreversible restrain of acetyl cholinesterase by the organ phosphorus pesticide .

结论氯乙醇对鼠肝线粒体钙泵的不可逆抑制作用可能与共价结合有关。

Conclusion The damage of CE on the calcium pump of mitochondria might be irreversible because of the formation of covalent binding of CE-target macromolecules .

在酶反应体系中，不同浓度的抗坏血酸对LDHm均具有可逆抑制作用，并存在量效关系。

When changing fixed levels of ascorbic acid were added to the reaction system , ascorbic acid functioned as a reversible inhibitor and had stoichiometric relation to its effect .

研究结果表明，苯甲酸对蘑菇酪氨酸酶的单酚酶和二酚酶活性均有抑制作用，其效应为可逆抑制效应。

The inhibition kinetics and mechanism of the enzyme were studied , and the results show that the inhibition of tyrosinase by benzoic acid is a reversible reaction with remaining enzyme activity .

椎管内给予RTX能可逆性抑制SP表达长达28天。

Intrathecal RTX could reversibly inhibit SP expression for 28 days . 3 .

结论Nifedipine具有可逆的抑制HHCC增殖功能。

Conclusion Nifedipine can inhibit cell proliferation of HHCC .

体内外研究结果表明：DMSO对血小板粘附和单一诱聚剂所致的聚集有可逆性抑制作用；

The results of in vivo and in vitro studies showed that DMSO could reversibly inhibit the platelet adhesion and its aggregation induced by the single aggregating agent .

结论AβP25-35可快速、可逆地抑制BK通道的活动，提示BK通道是AβP在脑内的一个作用靶点，BK通道的受损可能是AβP的神经毒性作用的机制之一。

Conclusion BK channels in cortical neurons might be one of the targets of ApP in AD brain , and the rapid and reversible suppression on BK channel activities might contribute to the neurotoxicity induced by A β P.

结论：LHRH融合蛋白疫苗对断奶后小鼠具有可逆性抑制性腺轴系功能的作用；断奶前组小鼠，体内抗LHRH抗体下降后注射睾酮，性腺轴系功能也可恢复。

Conclusion : The LHRH fusion protein vaccine can reversibly restrain the sexual virility of post-ablactation immature mice after ablactation , and the sexual virility can recover in the pre-ablactation mice injected with testosterone after the LHRH antibody decrease .

本文用大体动物实验和睾丸细胞培养两方面的研究结果证实了国产GnRH-A大剂量非脉冲性给药对雄性大鼠睾丸内分泌功能的可逆性抑制作用。

The results showed that long-term and non-pulsatile administration of high doses of GnRH-A made in China produced a reversible inhibition of testicular endocrine function in male rats , resulting in decrease of testosterone level and increase of progesterone level both in sera and culture media .

未发现不可逆骨髓抑制现象及肝功能受损。

No irreversible bone marrow depression and liver function injury was found .

通过蛋白酶活性位点丝氨酸残基的磺酰化，不可逆的抑制丝氨酸蛋白酶。

Irreversibly inhibits serine proteases by sulfonylation of the serine residue in the active site of the protease .

通过乙酰化酶活性位点剩余的组氨酸，不可逆的抑制胰蛋白酶（但不含胰凝乳蛋白酶）。

Irreversibly inhibits trypsin but not chymotrypsin by alkylating the histidine residue in the active site of the enzyme .

结果发现：海马脑片缺氧早期突触功能出现可逆性抑制，与外源施加高浓度腺苷反应类同。

The results showed that acute anoxia led to the reversible inhibition of synaptic function , which is similar to the response to addition of high concentration of exogenous adenosine .

本实验采用海马脑片细胞外记录技术，观察了缺氧早期突触功能可逆性抑制中腺苷的作用并初步探讨其作用机制。

The role of adenosine in reversible inhibition of synaptic function during the early stage of anoxia and its mechanisms were investigated with extracellular recording technique in rat hippocampal slices .

α-双炔失碳酯在体内能够通过作用于下丘脑-垂体-性腺轴可逆地抑制性腺及副性腺的生长，降低血浆睾酮水平。

α - anordrin could influence the level of T in serum and the growth of sex glands and accessory sex glands reversibly in vivo by inhibiting hypothalamus - pituitary - gonadal axis .

结论无手术应激情况下罗哌卡因硬膜外阻滞对细胞免疫功能产生轻微、可逆的抑制作用，对体液免疫功能无影响。

Conclusions Epidural block with ropivacaine produced sligh , reversible effect on cellular immunity in the condition of no stress of operation , but not on humoral immunity . But the inhibition is somewhat reversible .

本研究旨在探讨次黄嘌呤+dbcAMP或IBMX+dbcAMP对绵羊卵母细胞体外成熟的可逆性抑制作用，以及这种抑制作用对卵母细胞胚胎发育潜力的影响。

The aims of the present study were to assess the effect of various inhibitors ( hypoxanthine + dbcAMP or IBMX + dbcAMP ) on meiotic resumption and subsequent development to the blastocyst stage of ovine oocytes .

然而（－）THP可使蓝斑核去甲肾上腺素能神经元出现可逆性放电抑制。

( - ) THP induced inhibitory . firing of the neurons , however , irreversible .

在体外，HX能够可逆地部分抑制猪卵母细胞体外自发成熟，该作用具有剂量依赖性。

These results indicated that HX could partially inhibit the spontaneous meiotic maturation of pig oocytes in vitro in a dose-dependent manner ; This inhibitory effect is reversible .

毒性反应主要有轻度可逆性骨髓抑制，血液学毒性小于Ⅱ级。

The toxic reaction mainly had bone marrow inhibition .