卡托普利

卡托普利对血管平滑肌细胞内pH影响

Effect of captopril on intracellular pH in vascular smooth muscle

目的：比较A、B两厂复方卡托普利片的生物利用度和药代动力学。

OBJECTIVES : To compare the bioavailability and pharmacokinetics of captopril between products of two factories .

复方卡托普利片中卡托普利和氢氯噻嗪的HPLC测定

Determination of Captopril and Hydrochlorothiazide in Compound Captopril Tablets by HPLC

卡托普利增强豚鼠气道C神经纤维兴奋所致的收缩反应

Captopril increases the contractions of guinea pig airway induced by the activation of the nervous C fibers in vitro

其抗缺血作用机制及可能对梗死周围存活心肌的作用有待进一步研究。P＜0.00124小时动态心电图对心肌缺血负荷观察表明，卡托普利组从发病第7天至6个月间心肌缺血？

It is suggested that the anti-ischemic mechanism and the beneficial effect of captopril on the viable myocardium need further clarification .

血管紧张素II、卡托普利及氯沙坦对血管内皮细胞凋亡的影响

Effect of angiotensin II , captopril and losartan on apoptosis in vascular endothelial cells

高血压大鼠心脏肌凝蛋白重链mRNA表达和卡托普利的作用

Expression of cardiac myosin heavy chains mRNA in hypertensive rats and effect of captopril

目的联用卡托普利及倍他乐克治疗慢性充血性心力衰竭（CHF）观察疗效。

Objective To observe the effect of captopril and betaloc on chronic congestive heart failure ( CHF ) .

结论：以A厂复方卡托普利片为标准算得B厂复方卡托普利片中卡托普利的相对生物利用度（F）为99.37%。

CONCLUSIONS : The results showed that the bioavailability for the testing tablet was 99.37 % , the two formulations were bioequivalent .

卡托普利的HPLC测定

HPLC determination of captopril

结论：PGE1和卡托普利可能延缓PH的发展。

Conclusions : PGE 1 and captopril may delay the development of PH.

血钾在卡托普利组和培哚普利组均有上升（P＜0.005和P＜0.05），血钠水平3组间均无变化。

Plasma K + increased in the groups of captopril ( p < 0.005 ) and perindopril ( p < 0.05 ) but not in the nifedipine group .

RP-HPLC法测定卡托普利注射液含量的研究

Study of the Determination of the Captopril Injection by RP-HPLC

卡托普利可增强心肌组织SOD和GSHpx活性，减少LPO的生成；

Captopril promoted myocardial SOD . GSH Px activities and decreased LPO content ;

方法家兔24只，随机分为假手术组（A组）、缺血组（B组）和卡托普利组（C组）。

Methods Twenty-four albino rabbits were randomly divided into three groups : sham operation group ( A ), control group ( B ) and captopril group ( C ) .

目的研究卡托普利和缬沙坦对心肌梗死（MI）后胶原网络（cardiaccollagennet-work，CCN）重塑的作用及作用机制。

Objective To study the effects of captopril and valsartan on cardiac collagen net-work remodeling .

早期卡托普利治疗对SHR大鼠左心功能的长期影响

Long-Term Effect of Early Captopril Treatment on the Left Ventricular Performance in SHR

卡托普利对兔血浆t-PA和PAI-1活性水平的影响

The effect of captopril on the plasma activity of t-PA and PAI-1

各剂量组均有降低Lvw忍W作用，与模型组比较，中剂量组和高剂量组有显著性差异（P<0.05），高剂量组优于卡托普利组。

The effect of high dose group is better than Captopril Tablets group .

高血压病患者ACE基因I/D多态性与卡托普利咳嗽副反应、ACE水平的关系

Association Between Captopril Induced Cough , Level of ACE and ACE I / D Polymorphism in Patients with Hypertension

卡托普利对自发性高血压大鼠血压和心肌血管组织ATⅡ、ET、NE和DA的影响

Effect of captopril on blood pressure and angiotensin ⅱ, endothelin , noradrenaline and dopamine of myocardium and aorta in spontaneously hypertensive rats

口服给药4个小时后，抑制肽的降压效果明显好于卡托普利（P0.01）。

After 4 h of administration , the ACE inhibitory peptide showed more powerfully antihypertensive effect than captopril ( P 0.01 ) .

结论①卡托普利明显降低斑块局部CRP的表达，减轻斑块局部的炎症反应；

Conclusion Captopril can reduce the expression of CRP in local plaques of aortic atherosclerosis , and suppress vascular inflammation .

卡托普利及维拉帕米均能显著延长诱发AF患者的AERP；

Catopril and Verapamil could significantly lengthen AERP of the patients with AF.

卡托普利对大鼠TRAM皮瓣成活影响的实验研究

Experimental Study of the Effect of Captopril on TRAM Flap Survival in Rats

卡托普利、非洛地平对高血压患者循环中AngⅡ、NO及PCⅢ浓度影响的对比研究

Effect of Captopril and Felodipine on Circulating Concentrations of Angiotension ⅱ, Nitric Oxide and Type ⅲ Procollagen in Patients with Mild or Moderate Essential Hypertension

主要内容如下：1.利用药物卡托普利（Cap）实现了棒状金纳米颗粒在高离子强度溶液中的组装。

The main contents are as follow : 1.Assemblies of gold nanorods ( Au-NRs ) induced by captopril ( Cap ) in high ionic strength solutions .

结论2型糖尿病患者QTc间期延长，卡托普利可使延长的QTc间期缩短。

Conclusions QTc interval prolongs in patients with type 2 diabetes .

目的分析13597例急性心肌梗死（AMI）患者心电图特征及卡托普利的作用。

Aim To analyze the relationship between electrocardiogram characteristics and the effect of captopril in patients with acute myocardial infarction ( AMI ) .

卡托普利延迟起释型缓释片的研制、质量控制及其在Beagle犬内药代动力学研究

Preparation 、 Quality Control and Pharmacokinetics in Beagle Dogs of Captopril Delayed-onset , Sustained Release Tablet