六神丸

六神丸对H（22）肝癌抑瘤及减毒效果的实验研究

The experimental study on anti-neoplasms and attenuation effects of LiuShen Pill in the treatment of H_ ( 22 ) liver carcinoma

MTT法测定六神丸对HL-60细胞的增殖抑制作用。

MTT assay detects the growth inhibition effect of Liu-Shen-Wan on HL-60 cells .

六神丸对RAS影响肿瘤血管生长的实验研究

Experimental Research for the Mechanism of Liu-Shen Pill on Tumor Angiogenesis by RAS

结论六神丸对肿瘤血管形成均有明显抑制作用，降低VEGF的表达可能是其抑制肿瘤血管形成的主要机制之一。

Reducing the expression of VEGF are the important mechanisms of Liushen pill in inhibiting the angiogenesis of tumor .

用中药血清药理学方法观察六神丸诱导HL-60细胞凋亡的实验研究

The Experimental Study of Liu-shen-wan on Inducing HL-60 Cell Apoptosis with Chinese Herbs Serum Pharmacology Method

结果：六神丸近期客观疗效主要为NC，对吞咽困难、疼痛、呕吐等肿瘤常见症状有改善作用；

Results : The objective theraputic effect of Six Spirits Pill was NC . It could Improve dysphagia , pain , vomit and other normal symptoms .

原位末端标记表明：六神丸乙醇提取剂诱导HL-60细胞凋亡在一定范围内呈时间-浓度依赖关系；

In situ end-labeling method ( POD ) indicates : HL-60 cells apoptosis induced by Liu-Shen-Wan alcohol extraction have time-concentration dependency relation within certain ranges ;

中剂量组所得六神丸含药血清对HL-60细胞增殖抑制优于低剂量组和高剂量组。

As far as the growth inhibition effect is concerned , the middle-dose group of Liu-Shen-Wan medicine-serum is superior to the low-dose group and high-dose group .

六神丸含药血清可在体外抑制A（549）细胞增殖，其抑制作用以诱导凋亡为主，细胞周期分析示细胞阻滞于S期，基因检测发现六神丸含药血清可以降低bcl-2基因表达蛋白的水平。

The Six Spirits Pill serum could inhibit proliferation of A549 through inducing apoptosis . We found the cells were inhibited in S stage , and it could reduce the expression of bcl-2 . Conclusion .

3用MTT法、胎盘蓝染色法观察六神丸对HL-60细胞的增殖抑制作用，确定最佳血清制备方案。

MTT and trypan blue assay detects the growth inhibition effect of Liu-Shen-Wan on HL-60 cells and to make certain the best scheme of making method of medicine serum of Liu-Shen-Wan .

方法：选择HL-60细胞为实验对象，以六神丸及其主要成分之一的蟾酥进行该实验。

Methods : Using HL-60 cells as experimental object the experimental research of Chansu ( toad cake Venenum Bufonis ), the chief component of Liu Shen Wan , was carried out .

目的：观察六神丸对非小细胞肺癌及人高转移肺腺癌细胞株A549的抑制作用，进一步探讨六神丸抗肿瘤的作用机理。

Objective : To observe the supression of liu-shen Pill on non-small-cell lung cancer and lung cancer cells A549 , and further to discuss the mechanism of liu-shen Pill on anti-tumor .

由此推论六神丸不仅对恶性肿瘤细胞具有直接杀灭作用，亦可以通过RAS系统抗肿瘤血管生成途径等多角度实现抗肿瘤作用。

It seems therefore that Liushen pill have a direct role to kill the malignant cells , may also , through the RAS system , anti-tumor angiogenesis approaches realize the perspective of many anti-tumor effects .

目的探讨小剂量柳氮磺胺吡啶（SASP）口服、丹参注射液静滴联合六神丸、云南白药保留灌肠治疗活动期轻中度溃疡性结肠炎的临床疗效。

Objective To approach the clinical therapeutic effects on light or mid-range ulcerative colitis by small dose sulfasalazine ( SASP ), Danshen root injection , association with Liushen pill .

复方丹参和六神丸联合治疗带状疱疹

The Treatment of Herpes Zoster with Salvia Miltiorrhiza Compound and Liu-shen-wan

六神丸对肾上腺作用的实验研究

An Experimental Study on Effect of Liu Shen Wan on Adrenal Gland

气相色谱法测定27种六神丸中龙脑与异龙脑含量

Determination of Borneol and Isoborneol in 27 Species of Liu-Shen-Wan by GC

六神丸糊剂治疗白血病化疗致口腔溃疡疗效观察

Effect of Liushen Pill Paste on Chemotherapy-induced Oral Ulcer in Leukemia Patients

β-环糊精在六神丸中的应用&2种六神丸的药剂学对比研究

Application of β - Cyclodextrin Inclusion Complex in Liushen Pills

老药新用，扩大六神丸的应用范围。

To enlarge the clinical application of liu-shen-wan .

六神丸逆转白血病细胞多药耐药作用及相关机制研究

Research of Liu Shen Pill Reversing the Multidrug Resistance Effect and Correlation Mechanism of Leukemia Cell

老药新用六神丸

Old medicine , new usage

目的建立测定六神丸中脂蟾毒配基的离子抑制色谱分析法。

Purpose To establish a method for the determination of resibufogenin in Liushen pills by ion suppression chromatography .

六神丸抗肺癌转移及其作用靶点的实验及临床研究

Clinical and Experimental Research of Six Spirits Pill on Inhibiting the Metastasis of Lung Cancer and Functionary Target

目的：1研究六神丸含药血清的制备，探讨六神丸血清药理学的实验方法。

To study the making method of medicine serum of Liu-Shen-Wan , to explore Liu-Shen-Wan serum pharmacology method .

目的研究复方丹参和六神丸联合治疗带状疱疹的疗效。

Objective To research the curative effect on curing herpes zoster with the combination of salvia miltiorrhiza compound and liu-shen-wan .

目的：观察六神丸对恶性肿瘤的治疗作用，探讨六神丸治疗恶性肿瘤的机理。

Objective : To observe the theraputic effect on malignant tumor with Six Spirits Pill , and discuss its mechanism .

目的比较中药六神丸与亚砷酸作为乳牙牙髓失活剂用于乳牙干髓术中的疗效及安全性。

Objective To compare the curative effects and safety between Liushen Pills and arsenous acid as endodontic sealer in mummification of baby tooth .

六神丸是中国传统中药，疗效显著，被中外人士誉为创世纪产品。

Liu Shen Wan ( Pill of Six Ingredients with Magical Effects ) is a traditional Chinese medicine with marked curative effect and has Been praised as an " epoch-making product " By people at home and aBroad .

故六神丸除具有对恶性肿瘤或癌细胞的直接杀灭作用外，还可以通过抗血管生成机理实现抗癌抗肿瘤的作用，与化疗药物联用，可产生协同作用。

So liu-shen-wan can not only kill the malignant or cancer cells directly , but also can restrict them with the method of from anti-tumor angiogenesis mechanism . Combined with the DDP in using can get the better effect .