乏氧细胞

探讨乏氧细胞放射增敏剂的蛋白酶抑制活性。

OBJECTIVE To discuss the inhibitive activity of proteinase of hypoxic cells radiosensitizer .

目的：影响肿瘤放疗疗效的重要因素之一是实体瘤中存在10%～50%的乏氧细胞[1]，它们对低LET射线具有抗拒作用。

Objective : One of important factors that influence the curative effect of tumor radiotherapy is that there are 10 % ~ 50 % anoxic cells in the solid tumor , which have the function of resistance to the low LET beam .

辐射增敏剂CMCa为甲硝基咪唑类衍生物，它对肿瘤乏氧细胞有明显的辐射致敏作用，且能浓集癌组织内，是一种有辐射增敏及肿瘤定位特性的化合物。

Metronidazole derivative CMCa is a kind of radiosensitizers to tumor hypoxic cells . It can highly concentrated in cancer tissues .

具有蛋白酶抑制作用的乏氧细胞放射增敏剂Tx-1836

Radiosensitizer of hypoxic cell with inhibitive action of proteinase

乏氧细胞放射增敏剂研究进展

Recent Advance of Research on Hypoxic Cell Radiosensitizer

2-硝基咪唑类乏氧细胞放射线增敏剂的合成及其抑制血管增生作用

The Design and Synthesis of 2 nitroimidazoles Compounds as a Hypoxic Cell Radiosensitizer and Their Anti angiogenic Activity

肿瘤乏氧细胞的放射抗拒性问题一直是放射肿瘤学和放射生物学研究的重点之一。

Radiation resistance of hypoxic tumor cells is one of the key points in radiation oncology and biology .

主要原因是肿瘤细胞放射治疗敏感性较低，尤其是肿瘤细胞中的乏氧细胞对放射线的抗拒。

The main reason is the lower sensitivity of radiotherapy in cancer cells , especially in hypoxic tumor cells which is resistant to radiation .

在乏氧细胞中，许多基因呈乏氧依赖性表达，包括血管生成相关基因、葡萄糖转运相关基因、糖酵解相关基因、红细胞生成相关基因以及凋亡相关基因等。

Upon hypoxia stimuli , a lot of genes are activated , including angiogenesis related genes , glucose transport related genes , glycolysis related genes , erythropoiesis related genes and apoptosis related genes .

利用放射增敏剂提高肿瘤中乏氧细胞对放疗的敏感性，能提高放射线对肿瘤细胞的杀伤率，增强放疗效果。

The purpose of increasing radiosensitization of tumor is to enhance the killing effect of irradiation on tumor cells , especially on anoxic cells of tumor , and improve curative effect of radiotherapy .

而乏氧细胞对放射线相对不敏感，在正常组织的耐受剂量范围内不能完全杀死乏氧细胞，为肿瘤的复发和转移埋下了隐患。

Hypoxic cells are relatively non sensitive to radiation and the hypoxic cells could not be killed completely in the tolerant dose range of normal tissue . This planted a hidden danger for tumor recurrence and metastasis .

大黄素对乏氧鼻咽癌细胞的放射增敏性与DNA修复基因的关系

Correlation of enhancement radiosensitization of emodin isolated from Guangxi P. multiflorum Thunb on hypoxic nasopharyngeal cancer cells with expression of DNA repair genes

乏氧HeLa细胞的超微结构

Ultrastructures of Hypoxic HeLa Cells

结论：1.依他硝唑和紫杉醇联合应用对乏氧HeLa细胞具有协同放射增敏作用，本课题为临床放射治疗提供了一种新的给药组合。

The synergistic radiosensitizing effect of etanidazole and paclitaxel on hypoxic HeLa cells was observed . The study provided a new combination of radiosensitizers to radiotherapy . 2 .

乏氧肿瘤细胞对放射治疗、化学治疗的耐受性增强。

Hypoxic tumor cells exhibit increased resistance to radiotherapy and chemotherapy .

隔药饼灸对乏氧肿瘤细胞及肿瘤放疗免疫系统的影响

Indirect Moxibustion on Hypoxic Tumor Cells and Immunological Function of Tumor Undergoing Radiotherapy

乏氧肿瘤细胞的存在是患者恶性肿瘤治疗失败、复发和转移的重要原因之一。

The existence of hypoxic cells is one of the most important reasons for treatment failure , relapse and metastasis .

在乏氧的T98G细胞中也可以观察到X-射线照射所诱导的旁观者效应；

There was bystander effect in the hypoxic human glioblastoma T98G cells induced by X-ray .

尽管乏氧给肿瘤细胞的生长造成了不利的局面，但一系列基因和代谢的改变使肿瘤细胞能在不利的环境中存活甚至增殖。

Although hypoxia induces a situation unfavorable for cell growth , cancer cells may undergo a series of genetic and metabolic changes that allow them to survive and even proliferate .

乏氧对乳腺癌细胞增殖的影响及与Notch通路关系的实验研究

Effects of Hypoxia on Proliferation of Human Breast Cancer Cells and the Empirical Study of the Relationship between Hypoxia and Notch Signaling

乏氧通过肿瘤干细胞途径引起脑胶质瘤细胞放射敏感性改变的初步研究

The Preliminary Study on Radiosensitivity of Glioma Cells in Hypoxia Through Cancer Stem Cell

乏氧是所有实体肿瘤的内在特征，肿瘤乏氧细胞对传统的放射性治疗、光疗、化疗和免疫疗法都有抵制性。

Hypoxia is the essential character of human solid tumors . Hypoxic cancers are resistant to traditional radiotherapy , phototherapy , and chemotherapy , and also to conventional cancer immunotherapy .

肿瘤组织乏氧是恶性肿瘤的一个重要生物学特征，乏氧细胞的存在在实体瘤中是常见现象。

Hypoxia is an important characteristic of malignant tumor , and the presence of hypoxic cells in solid tumor is a common phenomenon .

沉默乏氧诱导因子-1α和生存素基因联合X射线照射对乏氧细胞的体外抑瘤效应

Anti-tumor effect of silencing Hif-1 α and Survivin genes combined with X-ray irradiation on hypoxic tumor cells in vitro

乏氧是近年来人们日益关注的问题，随着实体肿瘤的快速增长，供血和供氧相对不足，肿瘤组织内会出现低氧浓度区而形成乏氧细胞。

Hypoxia is paid more and more attention on in recent years . With the rapid growth of solid tumors , tumor tissue appears low oxygen concentrations within the area .