中心体复制
- 网络centrosome duplication
![中心体复制](../cache/1176402.jpg)
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我们结合转染技术及间接免疫荧光技术,观察细胞内DOC-1R转染基因表达对于DNA复制以及中心体复制的影响。
In the present study , the effect of DOC - 1R expression on DNA replication and centrosome duplication was investigated using plas-mid DNA transfection and dual immunofluorescent microscopy .
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中心体复制周期的异常会导致单极或多极纺锤体的形成,后者一直被认为是染色体不稳定和肿瘤发生的原因。
Aberrations in the centrosome duplication cycle result in the formation of monopolar or multipolar spindles , and it has been long proposed that such aberrations may cause aneuploidy and contribute to cancer development .
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中心体复制过程与细胞核内其他事件相耦合,并与DNA复制一样,以半保留方式复制。
Duplication of the centrosome is semiconservative and is coordinated with other cell cycle events , including DNA synthesis .
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癌基因BMI-1对中心体复制的调节作用
Role of Oncogene BMI-1 in Centrosomal Duplication
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癌基因BMI-1在中心体复制扩增的调节中起着重要的作用。
These data strongly indicated that BMI-1 plays critical role in the regulation of centrosomal duplication .
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研究中心体复制调控机制,对肿瘤的早期诊断和治疗有重要的作用。
The study of regulation mechanism about centrosome replication can play an important role in early diagnosis and treatment of tumor .
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中心体复制与细胞周期事件相耦合,许多细胞周期调节蛋白和中心体蛋白调节着中心体的复制,中心体复制还受癌基因和抑癌基因及其表达产物的调节。
A lot of factors can regulate the replication of centrosome including some cycle regulatory proteins and centrosomal proteins . oncogene . suppressor gene and their expression products .
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CaMKⅡ作为Ca2+的下游信号分子,在受精后促进成熟促进因子(MPF)和细胞静止因子(CSF)的失活,并调节纺锤体微管的组装和中心体的复制过程。
As one of the down stream signaling molecules of calcium , CaMK ⅱ facilitates the inactivation of maturation promoting factor ( MPF ) and cytostatic factor ( CSF ) following fertilization , as well as the spindle microtubule organization and centrosome duplication .
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细胞中心体的复制与调控
Replication and Regulation of Cell Centrosome
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因此在分裂细胞中,中心体的复制和分离必须与染色体的复制和分离过程相协调。
Therefore , centrosome duplication and segregation need to be tightly coordinated with the duplication and segregation of the genome .
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中心体的正常复制对于细胞分裂时双极纺锤体的形成、染色体的正确分离是至关重要的。
Centrosome duplication is a key requirement for bipolar spindle formation and correct segregation of chromosomes during cell division .
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现已发现了许多中心体蛋白及与中心体复制相关的蛋白激酶,调控着中心体复制的各个步骤。
Many centrosome - related proteins and kinases have been found to regulate different steps of centrosome duplication .