中心体复制

我们结合转染技术及间接免疫荧光技术，观察细胞内DOC-1R转染基因表达对于DNA复制以及中心体复制的影响。

In the present study , the effect of DOC - 1R expression on DNA replication and centrosome duplication was investigated using plas-mid DNA transfection and dual immunofluorescent microscopy .

中心体复制周期的异常会导致单极或多极纺锤体的形成，后者一直被认为是染色体不稳定和肿瘤发生的原因。

Aberrations in the centrosome duplication cycle result in the formation of monopolar or multipolar spindles , and it has been long proposed that such aberrations may cause aneuploidy and contribute to cancer development .

中心体复制过程与细胞核内其他事件相耦合，并与DNA复制一样，以半保留方式复制。

Duplication of the centrosome is semiconservative and is coordinated with other cell cycle events , including DNA synthesis .

癌基因BMI-1对中心体复制的调节作用

Role of Oncogene BMI-1 in Centrosomal Duplication

癌基因BMI-1在中心体复制扩增的调节中起着重要的作用。

These data strongly indicated that BMI-1 plays critical role in the regulation of centrosomal duplication .

研究中心体复制调控机制，对肿瘤的早期诊断和治疗有重要的作用。

The study of regulation mechanism about centrosome replication can play an important role in early diagnosis and treatment of tumor .

中心体复制与细胞周期事件相耦合，许多细胞周期调节蛋白和中心体蛋白调节着中心体的复制，中心体复制还受癌基因和抑癌基因及其表达产物的调节。

A lot of factors can regulate the replication of centrosome including some cycle regulatory proteins and centrosomal proteins . oncogene . suppressor gene and their expression products .

CaMKⅡ作为Ca2+的下游信号分子，在受精后促进成熟促进因子（MPF）和细胞静止因子（CSF）的失活，并调节纺锤体微管的组装和中心体的复制过程。

As one of the down stream signaling molecules of calcium , CaMK ⅱ facilitates the inactivation of maturation promoting factor ( MPF ) and cytostatic factor ( CSF ) following fertilization , as well as the spindle microtubule organization and centrosome duplication .

细胞中心体的复制与调控

Replication and Regulation of Cell Centrosome

因此在分裂细胞中，中心体的复制和分离必须与染色体的复制和分离过程相协调。

Therefore , centrosome duplication and segregation need to be tightly coordinated with the duplication and segregation of the genome .

中心体的正常复制对于细胞分裂时双极纺锤体的形成、染色体的正确分离是至关重要的。

Centrosome duplication is a key requirement for bipolar spindle formation and correct segregation of chromosomes during cell division .

现已发现了许多中心体蛋白及与中心体复制相关的蛋白激酶，调控着中心体复制的各个步骤。

Many centrosome - related proteins and kinases have been found to regulate different steps of centrosome duplication .