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OBJECTIVE : To evaluate the clinical efficacy and ADRs of Yaotuitong pills ( YTT ) .

目的：评价腰腿痛丸的临床疗效和不良反应。

CONCLUSION : YTT is safe and effective in treatment of various osteoarthropathy , lumbar degeneration , lumbar muscle strain and sciatica .

结论：腰腿痛丸用于治疗各种骨关节炎、各种腰椎退行性变以及腰肌劳损、坐骨神经痛等疾病是安全和有效的。

Objective : To study the effects of Yangxing Tongmai Tablets ( YTT ) on insulin receptor of Insulin Resistance Syndrome ( IRS ) .

目的：研究养心通脉片对胰岛素抵抗综合征（IRS）胰岛素受体的影响。

Conclusion : YTT had the roles with inhibiting over proliferation of vascular smooth muscle cells and preventing formation and development of IRS through improving insulin sensitivity , inhibiting C-myc mRNA expression and following reducing the level of PDGF-A mRNA .

结论：养心通脉片能通过改善机体胰岛素敏感性，抑制C-myc基因mRNA的表达，而下调PDGF-amRNA的表达水平，有利于进一步抑制血管平滑肌细胞的过度增殖，防止IRS的发生、发展。

Conclusion : The function of YTT and MFT in treating IRS may be related to those factors : enhancing ATPase activity decreasing ( Ca2 + ) I , inhibiting Ca2 + overload and resisting to lipids peroxidation of erythrocyte membrane .

结论：养心通脉片和二甲双胍对IRS患者的治疗作用可能与其提高ATP酶活性、降低（Ca2+）I含量、抑制Ca2+超载、对抗细胞膜脂质过氧化损伤，从而使细胞功能得到保护有关；